Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity

ACS Chemical Biology

Volumn 5, Issue 9, 2010, Pages 829-838

  Kwan, David H ^a,b   Leadlay, Peter F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 DEOXYERYTHRONOLIDE B SYNTHASE; ENOYLREDUCTASE; ENZYME; FATTY ACID SYNTHASE; LYSINE; POLYKETIDE SYNTHASE; RAPAMYCIN; RAPAMYCIN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ENZYME ACTIVE SITE; MUTAGENESIS; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOSPECIFICITY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CLONING, MOLECULAR; ESCHERICHIA COLI; LACTONES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SACCHAROPOLYSPORA; SEQUENCE ALIGNMENT; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 77956942908     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100175a     Document Type: Article

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