Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin

Archives of Biochemistry and Biophysics

Volumn 370, Issue 1, 1999, Pages 51-58

  Verdier Pinard, Pascal ^a   Sitachitta, Namthip ^b   Rossi, James V ^b   Sackett, Dan L ^a   Gerwick, William H ^b   Hamel, Ernest ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Antimitotic drugs; Colchicine site; Curacin A; Lyngbya majuscula; Microtubule inhibitor

Indexed keywords

ANTIMITOTIC AGENT; CARBON 14; COLCHICINE; CURACIN A; TUBULIN; UREA;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER INHIBITION; COVALENT BOND; DRUG INHIBITION; DRUG SYNTHESIS; INHIBITION KINETICS; ISOTOPE LABELING; LYNGBYA MAJUSCULA; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; SCATCHARD PLOT; STOICHIOMETRY;

LYNGBYA MAJUSCULA; NEGIBACTERIA;

EID: 0033214211     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1999.1363     Document Type: Article

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