Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11144-11149

  Ames, Brian D ^a   Nguyen, Chi ^a   Bruegger, Joel ^a   Smith, Peter ^a   Xu, Wei ^b   Ma, Suzanne ^b   Wong, Emily ^a   Wong, Steven ^a   Xie, Xinkai ^b   Li, Jesse W H ^c   Vederas, John C ^c   Tang, Yi ^b   Tsai, Shiou Chuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MEDIUM CHAIN HYDROGENASE REDUCTASE; MEVINOLIN; OXIDOREDUCTASE; POLYKETIDE; TRANSACTING POLYKETIDE ENOYL REDUCTASE LOVC; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STEREOCHEMISTRY;

ASPERGILLUS; ATHEROSCLEROSIS; CANDIDA TROPICALIS; CATALYTIC DOMAIN; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; HUMANS; LOVASTATIN; MOLECULAR CONFORMATION; MUTATION; NADP; POLYKETIDE SYNTHASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TRANSCRIPTIONAL ACTIVATION;

EID: 84863966874     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113029109     Document Type: Article

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