Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity

European Journal of Medicinal Chemistry

Volumn 87, Issue , 2014, Pages 552-563

  Elhalem, Eleonora ^a   Recio, Roció ^b   Werner, Sabine ^c   Lieder, Franziska ^c   Calderón Montanõ, José Manuel ^b   López Lázaro, Miguel ^b   Fernández, Inmaculada ^b   Khiar, Noureddine ^a  

^a INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c ETH ZURICH   (Switzerland)

Author keywords

(R) and (S) Sulforaphane and homologues; Activation of Nrf2 factor; Cytotoxic activity; DAG methodology; Enantiodivergent synthesis

Indexed keywords

(1,2:5,6 DI O ISOPROPYLIDENE ALPHA D GLUCOFURANOSYL) 4 AZIDOBUTANESULFINATE; (1,2:5,6 DI O ISOPROPYLIDENE ALPHA D GLUCOFURANOSYL) 5 AZIDOPENTANESULFINATE; (1,2:5,6 DI O ISOPROPYLIDENE ALPHA D GLUCOFURANOSYL) 6 AZIDOHEXANESULFINATE; 1 AZIDO 4 (BUTYLSULFINYL) BUTANE; 1 AZIDO 4 (ETHYLSULFINYL) BUTANE; 1 AZIDO 4 (METHYLSULFINYL) BUTANE; 1 AZIDO 5 (METHYLSULFINYL) PENTANE; 1 AZIDO 6 (METHYLSULFINYL) HEXANE; 1 ISOTHIOCYANATO 4 (BUTYLSULFINYL) BUTANE; 1 ISOTHIOCYANATO 4 (ETHYLSULFINYL) BUTANE; 1 ISOTHIOCYANATO 5 (METHYLSULFINYL) PENTANE; 1 ISOTHIOCYANATO 6 (METHYLSULFINYL) HEXANE; 4 AZIDOBUTAN 1 OL; 4 AZIDOBUTYL 1 THIOACETATE; 4 AZIDOBUTYL METHANESULFONATE; 5 AZIDOPENTYL 1 THIOACETATE; 5 AZIDOPENTYL METHANESULFONATE; 5 METHYLSULFONYLOXYPENTYL METHANESULFONATE; 6 AZIDOHEXAN 1 OL; 6 AZIDOHEXYL 1 THIOACETATE; 6 AZIDOHEXYL METHANESULFONATE; ANTINEOPLASTIC AGENT; CISPLATIN; LACTIC ACID; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENANTIOMER; FETUS; HUMAN; HUMAN CELL; HYDROGEN BOND; LUCIFERASE ASSAY; LUNG FIBROBLAST; STAUDINGER REACTION; STEREOCHEMISTRY; STEREOSPECIFICITY; TRANSIENT TRANSFECTION; WITTIG REACTION;

EID: 84949116308     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.052     Document Type: Article

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