7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes

Carcinogenesis

Volumn 21, Issue 11, 2000, Pages 1983-1988

  Rose, Peter ^a,b   Faulkner, Kathy ^a   Williamson, Gary ^b   Mithen, Richard ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYLSULFINYLHEPTYLISOTHIOCYANATE; 8 METHYLSULFINYLOCTYLISOTHIOCYANATE; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CARCINOGEN; GLUCOSINOLATE; ISOTHIOCYANIC ACID DERIVATIVE; METHYLSULFINYLHEPTYLGLUCOSINOLATE; METHYLSULFINYLOCTYL GLUCOSINOLATE; PHENETHYL ISOTHIOCYANATE; PHENYLETHYLGLUCOSINOLATE; PLANT EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CONJUGATION; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; DRUG METABOLISM; DRUG POTENCY; DRUG URINE LEVEL; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTESTINE ABSORPTION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0033746135     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.11.1983     Document Type: Article

References (33)

1. The myrosinase-glucosinolate system, its organisation and biochemistry
2. Glucosinolates and their breakdown products in food and food plants
3. Myrosinase activity in bacteria as demonstrated by conversion of progoitrin to goitrin
4. Inhibition of rat liver cytochrome P450 isoenzymes by isothiocyanates and their conjugates: A structure-activity relationship study
5. Structure and mechanisms of cystolic quinone reductases
6. Antioxidant functions of sulforaphane: A potent inducer of phase II detoxification enzymes
7. Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli
8. Isothiocyanates as substrates for human glutathione transferases-structure-activity studies
9. Dietary glucosinolates as blocking-agents against carcinogensis-glucosinolate breakdown products assessed by induction of quinone reductase activity in murine HEPA1c1c7 cells
10. Effect of oltipraz, α-tocopherol, β-carotene and phenethyl isothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase
11. Induction of rat pancreatic glutathione-S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussel sprouts
12. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
13. Molecular mechanisms of c-jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates
14. On the cytotoxicity and genotoxicity of allyl and phenylethyl isothiocyanates and their parent glucosinolates sinigrin and gluconasturtin
15. Essential role of p53 in phenylethyl isothiocyanate induced apoptosis
16. Fruit, vegetables and cancer prevention: A review of the epidemiological evidence
17. Anticarcinogenic factors in plant foods: A new class of nutrients?
18. Vegetables, fruit and cancer prevention
19. Glucosinolates in Brassica: Occurrence and significance as cancer modulating agents
20. Effects of phenylethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic metabolizing enzymes and nitrosamine metabolism in rats
21. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butone metabolism and the modulation of xenobiotic metabolising enzymes in rats and mice
22. Dose related inhibition by dietary phenethyl isothiocyanate of oesophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats
23. Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus
24. Intestinal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-butanone in rats: Sex differences, inducibility and inhibition by phenethylisothiocyanate
25. Effects of watercress consumption on urinary metabolites of nicotine in smokers
26. The inheritance of aliphatic glucosinolates in Brassica napus
27. The metabolism of benzyl isothiocyanate and its cysteine conjugates
28. Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtitre wells: A screening assay for anticarcinogenic enzyme inducers
29. Rapid detection of inducers of enzymes that protect against carcinogens
30. Glucosinolates and phenolics as antioxidants from plant foods
31. A major inducer of anticarcinogenic protective enzymes from broccoli-isolation and elucidation of structure
32. A urinary biomarker for uptake of dietary isothiocyanates in humans
33. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables