Combining cross-metathesis and activity-based protein profiling: New β-lactone motifs for targeting serine hydrolases

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 2, 2015, Pages 317-321

  Camara, Kaddy ^a   Kamat, Siddhesh S ^b   Lasota, Celina C ^a   Cravatt, Benjamin F ^b   Howell, Amy R ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

ABPP; Cross metathesis; Serine hydrolases; Methylene lactones; Lactones

Indexed keywords

HYDROLASE; LACTONE DERIVATIVE; LACTONE; METHYLENE-LACTONE; PROTEOME; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR;

ACTIVITY BASED PROTEIN PROFILING; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CROSS METATHESIS; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LACTONIZATION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING COMPETITION; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; ENZYMOLOGY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; STEREOISOMERISM; TUMOR CELL CULTURE;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CHROMATOGRAPHY, LIQUID; COLONIC NEOPLASMS; HUMANS; LACTONES; MICE; MOLECULAR STRUCTURE; PROTEOME; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84949116148     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.11.038     Document Type: Article

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