A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 8, 1998, Pages 977-978

  Dollinger, Lisa M ^a   Howell, Amy R ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; DRUG ANALOG; OXETANE DERIVATIVE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE;

ACYLATION; ARTICLE; ENZYME INHIBITION; HYDROGEN BOND;

ANIMALS; ENZYME INHIBITORS; ETHERS, CYCLIC; HETEROCYCLIC COMPOUNDS, 1-RING; LACTONES; LEUCINE; LIPASE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PANCREAS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0032554725     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00140-1     Document Type: Article

References (10)

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6. (c) Meier, M. K.; Blum-Kaelin, D.; Bremer, K.; Isler, D.; Joly, R.; Keller-Rupp, P.; Lengsfeld, H. Int. J. Obesity 1991 15 (Suppl. 1), 31.
7. 4. Barbier, P.; Schneider, F.; Widmer, U. Helv. Chim. Acta 1987, 70, 1412.
8. 5. This reaction was done with 1 equiv of 5 (normally 1.5 - 2.0 equiv are used). There were no other major products evident from a proton NMR spectrum of the crude reaction mixture. Nevertheless, the reaction was not as clean as we normally observe. Compound 2 was isolated as described in ref 1.
9. 6. (a) Borgstrom, B. Biochim. Biophys. Acta 1988, 962, 308.
10. (b) Cudrey, C.; van Tilbeurgh, H.; Gargouri, Y.; Verger, R. Biochemistry 1993, 32, 13800.