Total synthesis of tetrahydrolipstatin and stereoisomers via a highly regio- and diastereoselective carbonylation of epoxyhomoallylic alcohols

Journal of the American Chemical Society

Volumn 136, Issue 30, 2014, Pages 10814-10820

  Mulzer, Michael ^b   Tiegs, Brandon J ^b   Wang, Yanping ^a   Coates, Geoffrey W ^b   O'Doherty, George A ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b Department of Chemistry and Chemical Biology Baker Laboratory Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; FUNCTIONAL GROUPS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

COMPLEX MOLECULES; DIASTEREOSELECTIVE; ENANTIOSELECTIVE SYNTHESIS; LEWIS ACID; REGIO-SELECTIVE; TOTAL SYNTHESIS;

CARBONYLATION;

ALCOHOL DERIVATIVE; BETA LACTONE; EPOXIDE; EPOXYHOMOALLYLIC ALCOHOL DERIVATIVE; LACTONE DERIVATIVE; LEWIS ACID; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG; ALLYL ALCOHOL; ANTIOBESITY AGENT; ENZYME INHIBITOR; LACTONE; PROPANOL;

ARTICLE; CARBONYLATION; CATALYSIS; CATALYST; CHEMICAL PROCEDURES; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; REACTION ANALYSIS; REPRODUCIBILITY; STEREOCHEMISTRY; STEREOISOMERISM; CHEMISTRY; SYNTHESIS;

ANTI-OBESITY AGENTS; ENZYME INHIBITORS; EPOXY COMPOUNDS; LACTONES; PROPANOLS; STEREOISOMERISM;

EID: 84905216249     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja505639u     Document Type: Article

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