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Volumn 25, Issue 12, 2015, Pages 1299-1313

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

Author keywords

amino acid; Hippo; LAT1 CD98; mTOR; SLC7A5; YAP

Indexed keywords

AMINO ACID; HIPPO PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; WWTR1 PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

EID: 84949094384     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2015.140     Document Type: Article
Times cited : (165)

References (60)
  • 1
    • 84940467318 scopus 로고    scopus 로고
    • YAP and TAZ: A nexus for Hippo signaling and beyond
    • Hansen CG, Moroishi T, Guan KL. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol 2015; 25: 499-513
    • (2015) Trends Cell Biol , vol.25 , pp. 499-513
    • Hansen, C.G.1    Moroishi, T.2    Guan, K.L.3
  • 2
  • 3
    • 84898715615 scopus 로고    scopus 로고
    • The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
    • Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development 2014; 141: 1614-1626
    • (2014) Development , vol.141 , pp. 1614-1626
    • Varelas, X.1
  • 4
    • 84891748709 scopus 로고    scopus 로고
    • The two faces of Hippo: Targeting the Hippo pathway for regenerative medicine and cancer treatment
    • Johnson R, Halder G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Disco 2014; 13: 63-79
    • (2014) Nat Rev Drug Disco , vol.13 , pp. 63-79
    • Johnson, R.1    Halder, G.2
  • 5
    • 84916633921 scopus 로고    scopus 로고
    • The biology of YAP/TAZ: Hippo signaling and beyond
    • Piccolo S, Dupont S, Cordenonsi M. The biology of YAP/TAZ: hippo signaling and beyond. Physiol Rev 2014; 94: 1287-1312
    • (2014) Physiol Rev , vol.94 , pp. 1287-1312
    • Piccolo, S.1    Dupont, S.2    Cordenonsi, M.3
  • 6
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao B, Ye X, Yu J, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 2008; 22: 1962-1971
    • (2008) Genes Dev , vol.22 , pp. 1962-1971
    • Zhao, B.1    Ye, X.2    Yu, J.3
  • 7
    • 60849138138 scopus 로고    scopus 로고
    • Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
    • Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 2008; 135: 4059-4069
    • (2008) Development , vol.135 , pp. 4059-4069
    • Ota, M.1    Sasaki, H.2
  • 8
    • 0035873391 scopus 로고    scopus 로고
    • Tead/tef transcription factors utilize the activation domain of yap65, a src/yes-associated protein localized in the cytoplasm
    • Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev 2001; 15: 1229-1241
    • (2001) Genes Dev , vol.15 , pp. 1229-1241
    • Vassilev, A.1    Kaneko, K.J.2    Shu, H.3    Zhao, Y.4    DePamphilis, M.L.5
  • 9
    • 36549074631 scopus 로고    scopus 로고
    • YAP1 increases organ size and expands undifferentiated progenitor cells
    • Camargo FD, Gokhale S, Johnnidis JB, et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 2007; 17: 2054-2060
    • (2007) Curr Biol , vol.17 , pp. 2054-2060
    • Camargo, F.D.1    Gokhale, S.2    Johnnidis, J.B.3
  • 10
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of yap oncoprotein by the hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007; 21: 2747-2761
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1    Wei, X.2    Li, W.3
  • 11
    • 34548636132 scopus 로고    scopus 로고
    • Elucidation of a universal size-control mechanism in Drosophila and mammals
    • Dong J, Feldmann G, Huang J, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007; 130: 1120-1133
    • (2007) Cell , vol.130 , pp. 1120-1133
    • Dong, J.1    Feldmann, G.2    Huang, J.3
  • 12
    • 84902515862 scopus 로고    scopus 로고
    • Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
    • Yu FX, Luo J, Mo JS, et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell 2014; 25: 822-830
    • (2014) Cancer Cell , vol.25 , pp. 822-830
    • Yu, F.X.1    Luo, J.2    Mo, J.S.3
  • 13
    • 84902482143 scopus 로고    scopus 로고
    • Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry
    • Feng X, Degese MS, Iglesias-Bartolome R, et al. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell 2014; 25: 831-845
    • (2014) Cancer Cell , vol.25 , pp. 831-845
    • Feng, X.1    Degese, M.S.2    Iglesias-Bartolome, R.3
  • 14
    • 84939417563 scopus 로고    scopus 로고
    • Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the hippo pathway
    • Liu G, Yu FX, Kim YC, et al. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene 2015; 34: 3536-3546
    • (2015) Oncogene , vol.34 , pp. 3536-3546
    • Liu, G.1    Yu, F.X.2    Kim, Y.C.3
  • 15
    • 53849087493 scopus 로고    scopus 로고
    • Expression of Yes-associated protein in common solid tumors
    • Steinhardt AA, Gayyed MF, Klein AP, et al. Expression of Yes-associated protein in common solid tumors. Hum Pathol 2008; 39: 1582-1589
    • (2008) Hum Pathol , vol.39 , pp. 1582-1589
    • Steinhardt, A.A.1    Gayyed, M.F.2    Klein, A.P.3
  • 17
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • Zhou D, Conrad C, Xia F, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 2009; 16: 425-438
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1    Conrad, C.2    Xia, F.3
  • 18
    • 42349088170 scopus 로고    scopus 로고
    • A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
    • Chan SW, Lim CJ, Guo K, et al. A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res 2008; 68: 2592-2598
    • (2008) Cancer Res , vol.68 , pp. 2592-2598
    • Chan, S.W.1    Lim, C.J.2    Guo, K.3
  • 19
    • 84903158167 scopus 로고    scopus 로고
    • Regulation of mTORC1 by amino acids
    • Bar-Peled L, Sabatini DM. Regulation of mTORC1 by amino acids. Trends Cell Biol 2014; 24: 400-406
    • (2014) Trends Cell Biol , vol.24 , pp. 400-406
    • Bar-Peled, L.1    Sabatini, D.M.2
  • 20
    • 84894486696 scopus 로고    scopus 로고
    • Nutrient regulation of the mTOR complex 1 signaling pathway
    • Kim SG, Buel GR, Blenis J. Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells 2013; 35: 463-473
    • (2013) Mol Cells , vol.35 , pp. 463-473
    • Kim, S.G.1    Buel, G.R.2    Blenis, J.3
  • 22
    • 45849105156 scopus 로고    scopus 로고
    • The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • Sancak Y, Peterson TR, Shaul YD, et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008; 320: 1496-1501
    • (2008) Science , vol.320 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3
  • 23
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 1998; 273: 14484-14494
    • (1998) J Biol Chem , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 24
    • 84922727084 scopus 로고    scopus 로고
    • Metabolism differential regulation of mtorc1 by leucine and glutamine
    • Jewell JL, Kim YC, Russell RC, et al. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science 2015; 347: 194-198
    • (2015) Science , vol.347 , pp. 194-198
    • Jewell, J.L.1    Kim, Y.C.2    Russell, R.C.3
  • 25
    • 77953801358 scopus 로고    scopus 로고
    • Regulation of mTORC1 by the Rab and Arf GTPases
    • Li L, Kim E, Yuan H, et al. Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem 2010; 285: 19705-19709
    • (2010) J Biol Chem , vol.285 , pp. 19705-19709
    • Li, L.1    Kim, E.2    Yuan, H.3
  • 26
    • 59049087460 scopus 로고    scopus 로고
    • Bidirectional transport of amino acids regulates mTOR and autophagy
    • Nicklin P, Bergman P, Zhang B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009; 136: 521-534
    • (2009) Cell , vol.136 , pp. 521-534
    • Nicklin, P.1    Bergman, P.2    Zhang, B.3
  • 27
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110: 163-175
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3
  • 28
    • 0032528917 scopus 로고    scopus 로고
    • Amino acid availability regulates p70 S6 kinase and multiple translation factors
    • Wang X, Campbell LE, Miller CM, Proud CG. Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem J 1998; 334(Pt 1): 261-267
    • (1998) Biochem J , vol.334 , Issue.PT1 , pp. 261-267
    • Wang, X.1    Campbell, L.E.2    Miller, C.M.3    Proud, C.G.4
  • 29
    • 0037155888 scopus 로고    scopus 로고
    • Intracellular sensing of amino acids in xenopus laevis oocytes stimulates p70 s6 kinase in a target of rapamycin-dependent manner
    • Christie GR, Hajduch E, Hundal HS, Proud CG, Taylor PM. Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner. J Biol Chem 2002; 277: 9952-9957
    • (2002) J Biol Chem , vol.277 , pp. 9952-9957
    • Christie, G.R.1    Hajduch, E.2    Hundal, H.S.3    Proud, C.G.4    Taylor, P.M.5
  • 30
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002; 16: 1472-1487
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 31
    • 84896303323 scopus 로고    scopus 로고
    • The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle
    • Poncet N, Mitchell FE, Ibrahim AF, et al. The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PloS One 2014; 9: e89547
    • (2014) Plos One , vol.9 , pp. e89547
    • Poncet, N.1    Mitchell, F.E.2    Ibrahim, A.F.3
  • 32
    • 84876514626 scopus 로고    scopus 로고
    • Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
    • Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM, Cantrell DA. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 2013; 14: 500-508
    • (2013) Nat Immunol , vol.14 , pp. 500-508
    • Sinclair, L.V.1    Rolf, J.2    Emslie, E.3    Shi, Y.B.4    Taylor, P.M.5    Cantrell, D.A.6
  • 33
    • 0032541636 scopus 로고    scopus 로고
    • Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family
    • Mastroberardino L, Spindler B, Pfeiffer R, et al. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 1998; 395: 288-291
    • (1998) Nature , vol.395 , pp. 288-291
    • Mastroberardino, L.1    Spindler, B.2    Pfeiffer, R.3
  • 34
    • 0037083854 scopus 로고    scopus 로고
    • Activation of system L heterodimeric amino acid exchangers by intracellular substrates
    • Meier C, Ristic Z, Klauser S, Verrey F. Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J 2002; 21: 580-589
    • (2002) EMBO J , vol.21 , pp. 580-589
    • Meier, C.1    Ristic, Z.2    Klauser, S.3    Verrey, F.4
  • 35
    • 84933508767 scopus 로고    scopus 로고
    • A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
    • Moroishi T, Park HW, Qin B, et al. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev 2015; 29: 1271-1284
    • (2015) Genes Dev , vol.29 , pp. 1271-1284
    • Moroishi, T.1    Park, H.W.2    Qin, B.3
  • 36
    • 84943327329 scopus 로고    scopus 로고
    • MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
    • Meng Z, Moroishi T, Mottier-Pavie V, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun 2015; 6: 8357
    • (2015) Nat Commun , vol.6 , pp. 8357
    • Meng, Z.1    Moroishi, T.2    Mottier-Pavie, V.3
  • 37
    • 84929997950 scopus 로고    scopus 로고
    • LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation
    • Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nat Commun 2015; 6: 7250
    • (2015) Nat Commun , vol.6 , pp. 7250
    • Milkereit, R.1    Persaud, A.2    Vanoaica, L.3    Guetg, A.4    Verrey, F.5    Rotin, D.6
  • 38
    • 79956041076 scopus 로고    scopus 로고
    • The role of amino acid transporters in inherited and acquired diseases
    • Broer S, Palacin M. The role of amino acid transporters in inherited and acquired diseases. Biochem J 2011; 436: 193-211
    • (2011) Biochem J , vol.436 , pp. 193-211
    • Broer, S.1    Palacin, M.2
  • 39
    • 84891377474 scopus 로고    scopus 로고
    • Role of amino acid transporters in amino acid sensing
    • Taylor PM. Role of amino acid transporters in amino acid sensing. Am J Clin Nutr 2014; 99: 223S-230S
    • (2014) Am J Clin Nutr , vol.99 , pp. 223S-230S
    • Taylor, P.M.1
  • 40
    • 84937253537 scopus 로고    scopus 로고
    • The utilization of extracellular proteins as nutrients is suppressed by mTORC1
    • Palm W, Park Y, Wright K, Pavlova NN, Tuveson DA, Thompson CB. The utilization of extracellular proteins as nutrients is suppressed by mTORC1. Cell 2015; 162: 259-270
    • (2015) Cell , vol.162 , pp. 259-270
    • Palm, W.1    Park, Y.2    Wright, K.3    Pavlova, N.N.4    Tuveson, D.A.5    Thompson, C.B.6
  • 42
    • 84925970129 scopus 로고    scopus 로고
    • Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
    • Mo JS, Meng Z, Kim YC, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 2015; 17: 500-510
    • (2015) Nat Cell Biol , vol.17 , pp. 500-510
    • Mo, J.S.1    Meng, Z.2    Kim, Y.C.3
  • 43
    • 76149138881 scopus 로고    scopus 로고
    • Structural insights into the YAP and TEAD complex
    • Li Z, Zhao B, Wang P, et al. Structural insights into the YAP and TEAD complex. Genes Dev 2010; 24: 235-240
    • (2010) Genes Dev , vol.24 , pp. 235-240
    • Li, Z.1    Zhao, B.2    Wang, P.3
  • 44
    • 0036320205 scopus 로고    scopus 로고
    • Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    • Edinger AL, Thompson CB. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell 2002; 13: 2276-2288
    • (2002) Mol Biol Cell , vol.13 , pp. 2276-2288
    • Edinger, A.L.1    Thompson, C.B.2
  • 45
    • 84894523716 scopus 로고    scopus 로고
    • Making new contacts: The mTOR network in metabolism and signalling crosstalk
    • Shimobayashi M, Hall MN. Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol 2014; 15: 155-162
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 155-162
    • Shimobayashi, M.1    Hall, M.N.2
  • 46
    • 84891745585 scopus 로고    scopus 로고
    • Autophagy regulation by nutrient signaling
    • Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling. Cell Res 2014; 24: 42-57
    • (2014) Cell Res , vol.24 , pp. 42-57
    • Russell, R.C.1    Yuan, H.X.2    Guan, K.L.3
  • 47
    • 84922789990 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms and pathways
    • Efeyan A, Comb WC, Sabatini DM. Nutrient-sensing mechanisms and pathways. Nature 2015; 517: 302-310
    • (2015) Nature , vol.517 , pp. 302-310
    • Efeyan, A.1    Comb, W.C.2    Sabatini, D.M.3
  • 49
    • 84870610975 scopus 로고    scopus 로고
    • YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via MIR-29
    • Tumaneng K, Schlegelmilch K, Russell RC, et al. YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol 2012; 14: 1322-1329
    • (2012) Nat Cell Biol , vol.14 , pp. 1322-1329
    • Tumaneng, K.1    Schlegelmilch, K.2    Russell, R.C.3
  • 50
    • 84949089395 scopus 로고    scopus 로고
    • YAP1 and TAZ Activates mTORC1 pathway by regulating amino acid transporters in hepatocellular carcinoma
    • Sep 21
    • Park YY, Sohn BH, Johnson RL, et al. YAP1 and TAZ Activates mTORC1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology 2015 Sep 21. doi: 10.1002/hep.28223
    • (2015) Hepatology
    • Park, Y.Y.1    Sohn, B.H.2    Johnson, R.L.3
  • 51
    • 84908258052 scopus 로고    scopus 로고
    • Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
    • Liang N, Zhang C, Dill P, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med 2014; 211: 2249-2263
    • (2014) J Exp Med , vol.211 , pp. 2249-2263
    • Liang, N.1    Zhang, C.2    Dill, P.3
  • 52
    • 84939233417 scopus 로고    scopus 로고
    • Phosphorylation of the Hippo pathway component AMOTL2 by the mTORC2 kinase promotes YAP signaling, resulting in enhanced glioblastoma growth and invasiveness
    • Artinian N, Cloninger C, Holmes B, Benavides-Serrato A, Bashir T, Gera J. Phosphorylation of the Hippo pathway component AMOTL2 by the mTORC2 kinase promotes YAP signaling, resulting in enhanced glioblastoma growth and invasiveness. J Biol Chem 2015; 290: 19387-19401
    • (2015) J Biol Chem , vol.290 , pp. 19387-19401
    • Artinian, N.1    Cloninger, C.2    Holmes, B.3    Benavides-Serrato, A.4    Bashir, T.5    Gera, J.6
  • 53
    • 84935519595 scopus 로고    scopus 로고
    • Amino Acid transporters in cancer and their relevance to glutamine addiction novel targets for the design of a new class of anticancer drugs
    • Bhutia YD, Babu E, Ramachandran S, Ganapathy V. Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs. Cancer Res 2015; 75: 1782-1788
    • (2015) Cancer Res , vol.75 , pp. 1782-1788
    • Bhutia, Y.D.1    Babu, E.2    Ramachandran, S.3    Ganapathy, V.4
  • 54
    • 84885182528 scopus 로고    scopus 로고
    • Regulation of the Hippo pathway and implications for anticancer drug development
    • Park HW, Guan KL. Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci 2013; 34: 581-589
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 581-589
    • Park, H.W.1    Guan, K.L.2
  • 55
    • 84917709109 scopus 로고    scopus 로고
    • CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction
    • Estrach S, Lee SA, Boulter E, et al. CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Res 2014; 74: 6878-6889
    • (2014) Cancer Res , vol.74 , pp. 6878-6889
    • Estrach, S.1    Lee, S.A.2    Boulter, E.3
  • 56
    • 84949100701 scopus 로고    scopus 로고
    • Ubiquitination of CD98 limits cell proliferation and clonal expansion
    • Oct 22. pii: jcs.178129
    • Ablack JN, Cantor JM, Metz PJ, Chang JT, Ginsberg MH. Ubiquitination of CD98 limits cell proliferation and clonal expansion. J Cell Sci 2015 Oct 22. pii: jcs.178129
    • (2015) J Cell Sci
    • Ablack, J.N.1    Cantor, J.M.2    Metz, P.J.3    Chang, J.T.4    Ginsberg, M.H.5
  • 58
    • 11144242444 scopus 로고    scopus 로고
    • CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation
    • Henderson NC, Collis EA, Mackinnon AC, et al. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J Biol Chem 2004; 279: 54731-54741
    • (2004) J Biol Chem , vol.279 , pp. 54731-54741
    • Henderson, N.C.1    Collis, E.A.2    Mackinnon, A.C.3
  • 60
    • 84891766371 scopus 로고    scopus 로고
    • DNASU plasmid and PSI: Biology-Materials repositories: Resources to accelerate biological research
    • Seiler CY, Park JG, Sharma A, et al. DNASU plasmid and PSI: Biology-Materials repositories: resources to accelerate biological research. Nucleic Acids Rese 2014; 42: D1253-D1260
    • (2014) Nucleic Acids Rese , vol.42 , pp. D1253-D1260
    • Seiler, C.Y.1    Park, J.G.2    Sharma, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.