Hydroxysafflor yellow A exerts neuroprotective effects in cerebral ischemia reperfusion-injured mice by suppressing the innate immune TLR4-inducing pathway

European Journal of Pharmacology

Volumn 769, Issue , 2015, Pages 324-332

  Lv, Yanni ^a   Qian, Yisong ^a   Fu, Longsheng ^a   Chen, Xuanying ^a   Zhong, Haili ^a   Wei, Xiaohua ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

Anti inflammatory; Cerebral ischemia reperfusion; Hydroxysafflor yellow A; Neuroprotective effects; Neurotrophy; TLR4

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHALCONE; HYDROXYSAFFLOR YELLOW A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; QUINONE DERIVATIVE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

ANALOGS AND DERIVATIVES; ANIMAL; CEREBRAL ARTERY DISEASE; COMPLICATION; DRUG EFFECTS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MOUSE; PATHOLOGY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHALCONE; IMMUNITY, INNATE; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; NF-KAPPA B; QUINONES; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 84949032450     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.11.036     Document Type: Article

References (46)

1. K. Baldauf, and K.G. Reymann Influence of EGF/bFGF treatment on proliferation, early neurogenesis and infarct volume after transient focal ischemia Brain Res. 1056 2005 158 167
2. W. Barakat, N. Safwet, N.N. El-Maraghy, and M.N. Zakaria Candesartan and glycyrrhizin ameliorate ischemia brain damage through downregulation of the TLR signaling cascade Eur. J. Pharmacol. 724 2014 43 50
3. G.M. Barton, and R. Medzhitov Toll-like receptor signaling pathways Science 300 2003 1524 1525
4. A.M. Campbell, I.S. Zagon, and P.J. McLaughlin Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis Brain Res. Bull. 90 2013 43 51
5. L. Chen, Y. Xiang, L. Kong, X. Zhang, B. Sun, X. Wei, and H. Liu Hydroxysafflor yellow A protects against cerebral ischemia-reperfusion injury by anti-apoptotic effect through PI3K/Akt/GSK3β pathway in rat Neurochem. Res. 38 2013 2268 2275
6. O. Cheng, R. Li, L. Zhao, L. Yu, B. Yang, J. Wang, B. Chen, and J. Yang Short-term sleep deprivation stimulates hippocampal neurogenesis in rats following global cerebral ischemia/reperfusion PLoS One 10 2015 e0125877
7. G. Courties, M.A. Moskowitz, and M. Nahrendorf The innate immune system after ischemia injury: lessons to be learned from the heart and brain J. Am. Med. Assoc. Neurol. 71 2014 233 236
8. Y. Gao, X. Fang, Y. Tong, Y. Liu, and B. Zhang TLR4-mediated MyD88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in cortex in mice Biomed. Pharmacother. 63 2009 442 450
9. R. Gorina, M. Font-Nieves, L. Márquez-Kisinousky, T. Santalucia, and A.M. Planas Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways Glia 59 2011 242 255
10. T. Guan, Q. Liu, Y. Qian, H. Yang, J. Kong, J. Kou, and B. Yu Ruscogenin reduces cerebral ischemia injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke Eur. J. Pharmacol. 714 2013 303 311
11. Y. Guo, X. Xu, Q. Li, Z. Li, and F. Du Anti-inflammation effects of picroside 2 in cerebral ischemia injury rats Behav. Brain Funct. 9 2010 43
12. P.P. He Study on Hydroxy Safflower Yellow A Penetrating the Blood Brain Barrier under Cerebral Ischemia Reperfusion Injury Condition (Master thesis) 2009 Shandong University
13. F. Hua, H. Tang, J. Wang, M.C. Prunty, X. Hua, I. Sayeed, and D.G. Stein TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice J. Cereb. Blood Flow. Metab. 35 2015 536 542
14. H. Hu, Z. Li, X. Zhu, R. Lin, J. Peng, J. Tao, and L. Chen GuaLou GuiZhi decoction inhibits LPS-induced microglial cell motility through the MAPK signaling pathway Int. J. Mol. Med. 32 2013 1281 1286
15. D.B. Ji, L.Y. Zhang, C.L. Li, J. Ye, and H.B. Zhu Effect of hydroxysafflor yellow A on human umbilical vein endothelial cells under hypoxia Vasc. Pharm. 50 l 2009 137 145
16. Z. Jin, J. Liang, J. Wang, and P.E. Kolattukudy MCP-induced protein 1 mediates the minocycline-induced neuroprotection against cerebral ischemia/reperfusion injury in vitro and in vivo J. Neuroinflamm. 12 2015 39
17. G.B. Johnson, G.J. Brunn, Y. Kodaira, and J.L. Platt Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by toll-like receptor 4 J. Immunol. 168 2002 5233 5239
18. C.C. Lee, C.N. Wang, Y.L. Lee, Y.R. Tsai, and J.J. Liu High mobility group box 1 induced human lung myofibroblasts differentiation and enhancedmigration by activation of MMP-9 PLoS One 10 2015 e0116393
19. X.Q. Li, J. Wang, B. Fang, W.F. Tan, and H. Ma Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood-spinal cord barrier following ischemia/reperfusion injury in rats Mol. Brain 7 2014 28
20. O. Lindvall, P. Ernfors, J. Bengzon, Z. Kokaia, M.L. Smith, B.K. Siesjö, and H. Persson Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma Proc. Natl. Acad. Sci. USA 89 1992 648 652
21. X.Y. Liu., X.Y. Zhou, J.C. Hou, H. Zhu, Z. Wang, J.X. Liu, and Y.Q. Zheng Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway Acta Pharmacol. Sin. 36 2015 421 428
22. Y.L. Liu, Y.J. Liu, Y. Liu, X.S. Li, S.H. Liu, Y.G. Pan, J. Zhang, Q. Liu, and Y.Y. Hao Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways Int. Immunopharmacol. 23 2014 649 657
23. Y.N. Lv, X.H. Wei, and P. Xiao Study on action mechanism of Danhong injection based on computational system biology approach Zhongguo Zhong Yao Za Zhi 40 2015 538 542 (in Chinese)
24. P. Maud, O. Thavarak, L. Cédrick, B. Michèle, B. Vincent, P. Olivier, and B. Régis Evidence for the use of isoflurane as a replacement for chloral hydrate anesthesia in experimental stroke: an ethical issue Biomed. Res. Int. 2014 2014 802539
25. M.A. Moskowitz, E.H. Lo, and C. Iadecola The science of stroke: mechanisms in search of treatments Neuron 67 2010 181 198
26. M. Nikodemova, and J.J. Watters Outbred ICR/CD1 mice display more severe neuroinflammation mediated by microglial TLR4/CD14 activation than inbred C57Bl/6 mice Neuroscience 190 2011 67 74
27. P. Orsu, B.V. Murthy, and A. Akula Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in mice J. Neural Transm. 120 2013 1217 1223
28. S. Ozden, and S. Isenmann Neuroprotective properties of different anesthetics on axotomized rat retinal ganglion cells in vivo J. Neurotrauma 21 2004 73 82
29. J. Puyal, A. Vaslin, V. Mottier, and P.G. Clarke Postischemia treatment of neonatal cerebral ischemia should target autophagy Ann. Neurol. 66 2009 378 389
30. S.M. Quiniou, P. Boudinot, and E. Bengtén Comprehensive survey and genomic characterization of Toll-like receptors (TLRs) in channel catfish, Ictalurus punctatus: identification of novel fish TLRs Immunogenetics 65 2013 511 530
31. J. Ramos-Cejudo, M. Gutiérrez-Fernández, L. Otero-Ortega, B. Rodríguez-Frutos, B. Fuentes, M.T. Vallejo-Cremades, T.N. Hernanz, S. Cerdán, and E. Díez-Tejedor Brain-derived neurotrophic factor administration mediated oligodendrocyte differentiation and myelin formation in subcortical ischemia stroke Stroke 46 2015 221 228
32. J. Sun, Y. Li, W. Fang, and L. Mao Therapeutic time window for treatment of focal cerebral ischemia reperfusion injury with XQ-1h in rats Eur. J. Pharmacol. 666 2011 105 110
33. F. Tian, K. Deguchi, T. Yamashita, Y. Ohta, N. Morimoto, J. Shang, X. Zhang, N. Liu, Y. Ikeda, and T. Matsuura In vivo imaging of autophagy in a mouse stroke model Autophagy 6 2010 1107 1114
34. J. Tian, G. Li, Z. Liu, and F. Fu Hydroxysafflor yellow A inhibits rat brain mitochondrial permeability transition pores by a free radical scavenging action Pharmacology 82 2008 121 126
35. X.K. Tu, W.Z. Yang, J.P. Chen, Y. Chen, L.Q. Ouyang, Y.C. Xu, and S.S. Shi Curcumin inhibits TLR2/4-NF-κB signaling pathway and attenuates brain damage in permanent focal cerebral ischemia in rats Inflammation 37 2014 1544 1551
36. X. Wei, H. Liu, X. Sun, F. Fu, X. Zhang, J. Wang, J. An, and H. Ding Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action Neurosci. Lett. 386 2005 58 62
37. A.J. Williams, J.R. Dave, and F.C. Tortella Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration Neurochem. Int. 49 2006 106 112
38. Y. Wu, L. Wang, M. Jin, and B.X. Zang Hydroxysafflor yellow A alleviates early inflammatory response of bleomycin-induced mice lung injury Biol. Pharm. Bull. 35 2012 515 522
39. H.F. Xiang, D.H. Cao, Y.Q. Yang, H.Q. Wang, L.J. Zhu, B.H. Ruan, J. Du, and M.C. Wang Isoflurane protects against injury caused by deprivation of oxygen and glucose in microglia through regulation of the toll-like receptor 4 pathway J. Mol. Neurosci. 54 2014 664 670
40. K. Yamada, and T. Nabeshima Brain-derived neurotrophic factor/TrkB signaling in memory processes J. Pharmacol. Sci. 91 2003 267 270
41. S.Y. Ye, and W.Y. Gao Hydroxysafflor yellow A protects neuron against hypoxia injury and suppresses inflammatory responses following focal ischemia reperfusion in rats Arch. Pharm. Res. 31 2008 1010 1015
42. M. Yepes, S.A. Brown, E.G. Moore, E.P. Smith, D.A. Lawrence, and J.A. Winkles A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia Am. J. Pathol. 166 2005 511 520
43. C. Zheng, J. Han, W. Xia, S. Shi, J. Liu, and W. Ying NAD1 administration decreases ischemia brain damage partially by blocking autophagy in a mouse model of brain ischemia Neurosci. Lett. 512 2012 67 71
44. Y.Q. Zheng, J.X. Liu, X.Z. Li, L. Xu, and Y.G. Xu RNA interferencemediated downregulation of beclin1 attenuates cerebral ischemia injury in rats Acta Pharmacol. Sin. 30 2009 919 927
45. H.B. Zhu, L. Zhang, Z.H. Wang, J.W. Tian, F.H. Fu, K. Liu, and C.L. Li Therapeutic effects of hydroxysafflor yellow A on focal cerebral ischemic injury in rats and its primary mechanisms J. Asian Nat. Prod. Res. 7 2005 607 613
46. N. Zhang, M. Xing, Y. Wang, H. Liang, Z. Yang, F. Shi, and Y. Cheng Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus Neurosci. Bull. 30 2014 417 424