Hydroxysafflor yellow a protects against cerebral ischemia-reperfusion injury by anti-apoptotic effect through PI3K/Akt/GSK3β pathway in rat

Neurochemical Research

Volumn 38, Issue 11, 2013, Pages 2268-2275

  Chen, Lin ^a   Xiang, Yanxiao ^a   Kong, Lingjun ^a   Zhang, Xiumei ^a   Sun, Baozhu ^b   Wei, Xinbing ^a   Liu, Huiqing ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Hydroxysafflor yellow A; Ischemia reperfusion; PI3K Akt GSK3 pathway

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYSAFFLOR YELLOW A; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; DENSITOMETRY; DNA FRAGMENTATION; DRUG EFFICACY; DRUG STRUCTURE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; SAFFLOWER; SIGNAL TRANSDUCTION; TREATMENT RESPONSE;

CARTHAMUS TINCTORIUS; RATTUS; RATTUS NORVEGICUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN ISCHEMIA; CHALCONE; GLYCOGEN SYNTHASE KINASE 3; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; QUINONES; RATS; RATS, WISTAR; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84885955456     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1135-8     Document Type: Article

References (34)

1. Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22(9):391-397
2. Broughton BR, Reutens DC, Sobey CG (2009) Apoptotic mechanisms after cerebral ischemia. Stroke 40(5):e331-e339. doi: 10.1161/STROKEAHA.108.531632
3. Sun B, Chen L, Wei X, Xiang Y, Liu X, Zhang X (2011) The Akt/GSK-3beta pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. Biochem Biophys Res Commun 409(4):808-813. doi: 10.1016/j.bbrc.2011.05.095
4. Liu H, Liu X, Wei X, Chen L, Xiang Y, Yi F, Zhang X (2012) Losartan, an angiotensin II type 1 receptor blocker, ameliorates cerebral ischemia-reperfusion injury via PI3K/Akt-mediated eNOS phosphorylation. Brain Res Bull 89(1-2):65-70. doi: 10.1016/j.brainresbull.2012.06.010
5. Zhang J, Deng Z, Liao J, Song C, Liang C, Xue H, Wang L, Zhang K, Yan G (2013) Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway. J Cereb Blood Flow Metab 33(4):567-574. doi: 10.1038/jcbfm.2012.202
6. Noshita N, Lewen A, Sugawara T, Chan PH (2001) Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21(12):1442-1450. doi: 10.1097/00004647-200112000-00009
7. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296(5573):1655-1657. doi: 10.1126/science.296.5573.1655
8. Martin M, Rehani K, Jope RS, Michalek SM (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6(8):777-784. doi: 10.1038/ni1221
9. Jope RS, Johnson GV (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29(2):95-102. doi: 10.1016/j.tibs.2003.12.004
10. Beurel E, Jope RS (2006) The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 79(4):173-189. doi: 10.1016/j.pneurobio.2006.07.006
11. Zhao H, Sapolsky RM, Steinberg GK (2006) Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34(3):249-270. doi: 10.1385/MN:34:3:249
12. Zhu H, Wang Z, Ma C, Tian J, Fu F, Li C, Guo D, Roeder E, Liu K (2003) Neuroprotective effects of hydroxysafflor yellow A: in vivo and in vitro studies. Planta Med 69(5):429-433. doi: 10.1055/s-2003-39714
13. Wei X, Liu H, Sun X, Fu F, Zhang X, Wang J, An J, Ding H (2005) Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action. Neurosci Lett 386(1):58-62. doi: 10.1016/j.neulet.2005. 05.069
14. Sun X, Wei X, Qu S, Zhao Y, Zhang X (2010) Hydroxysafflor Yellow A suppresses thrombin generation and inflammatory responses following focal cerebral ischemia-reperfusion in rats. Bioorg Med Chem Lett 20(14):4120-4124. doi: 10.1016/j.bmcl.2010.05.076
15. Shan LQ, Ma S, Qiu XC, Zhou Y, Zhang Y, Zheng LH, Ren PC, Wang YC, Fan QY, Ma BA (2010) Hydroxysafflor Yellow A protects spinal cords from ischemia/reperfusion injury in rabbits. BMC Neurosci 11:98. doi: 10.1186/1471-2202-11-98
16. Yang Q, Yang ZF, Liu SB, Zhang XN, Hou Y, Li XQ, Wu YM, Wen AD, Zhao MG (2010) Neuroprotective effects of hydroxysafflor yellow A against excitotoxic neuronal death partially through down-regulation of NR2B-containing NMDA receptors. Neurochem Res 35(9):1353-1360. doi: 10.1007/s11064-010-0191-6
17. Chen L, Zhang Y, Sun X, Li H, LeSage G, Javer A, Zhang X, Wei X, Jiang Y, Yin D (2009) Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3beta pathway. Bioorg Med Chem 17(13):4378-4382. doi: 10.1016/j.bmc.2009.05.029
18. Chen L, Shi W, Li H, Sun X, Fan X, Lesage G, Li Y, Zhang Y, Zhang X, Yin D (2010) Critical role of toll-like receptor 9 in morphine and Mycobacterium tuberculosis-Induced apoptosis in mice. PLoS ONE 5(2):e9205. doi: 10.1371/journal.pone.0009205
19. Benchoua A, Guegan C, Couriaud C, Hosseini H, Sampaio N, Morin D, Onteniente B (2001) Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci 21(18):7127-7134
20. Ferrer I, Friguls B, Dalfo E, Justicia C, Planas AM (2003) Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat. Neuropathol Appl Neurobiol 29(5):472-481
21. Sugawara T, Chan PH (2003) Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 5(5):597-607. doi: 10.1089/152308603770310266
22. Ji DB, Zhang LY, Li CL, Ye J, Zhu HB (2009) Effect of hydroxysafflor yellow A on human umbilical vein endothelial cells under hypoxia. Vascul Pharmacol 50(3-4):137-145. doi: 10.1016/j.vph.2008.11.009
23. Ji DB, Zhu MC, Zhu B, Zhu YZ, Li CL, Ye J, Zhu HB (2008) Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax. J Cardiovasc Pharmacol 52(2):191-202. doi: 10.1097/FJC.0b013e318181fb02
24. Murphy KM, Streips UN, Lock RB (1999) Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2. Oncogene 18(44):5991-5999. doi: 10.1038/sj.onc.1203001
25. Li F, Omori N, Jin G, Wang SJ, Sato K, Nagano I, Shoji M, Abe K (2003) Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO. Brain Res 962(1-2):21-26
26. Friguls B, Justicia C, Pallas M, Planas AM (2001) Focal cerebral ischemia causes two temporal waves of Akt activation. NeuroReport 12(15):3381-3384
27. Liu SX, Zhang Y, Wang YF, Li XC, Xiang MX, Bian C, Chen P (2012) Upregulation of heme oxygenase-1 expression by hydroxysafflor yellow A conferring protection from anoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes. Int J Cardiol 160(2):95-101. doi: 10.1016/j.ijcard.2011.03.033
28. Yu SM, Kim SJ (2013) Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway. Exp Biol Med (Maywood). doi: 10.1177/1535370213492685
29. Kwon SH, Hong SI, Kim JA, Jung YH, Kim SY, Kim HC, Lee SY, Jang CG (2011) The neuroprotective effects of Lonicera japonica THUNB. against hydrogen peroxide-induced apoptosis via phosphorylation of MAPKs and PI3K/Akt in SH-SY5Y cells. Food Chem Toxicol 49(4):1011-1019. doi: 10.1016/j.fct.2011.01.008
30. Woodgett JR (2005) Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol 17(2):150-157. doi: 10.1016/j.ceb.2005.02.010
31. Leroy K, Brion JP (1999) Developmental expression and localization of glycogen synthase kinase-3beta in rat brain. J Chem Neuroanat 16(4):279-293
32. Pap M, Cooper GM (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 273(32):19929-19932
33. Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA (2004) Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 24(44):9993-10002. doi: 10.1523/JNEUROSCI.2057-04.2004
34. Kaga S, Zhan L, Altaf E, Maulik N (2006) Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and surviving expression in rat ischemic preconditioned myocardium. J Mol Cell Cardiol 40(1):138-147. doi: 10.1016/j.yjmcc.2005.09.009