Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway

Acta Pharmacologica Sinica

Volumn 36, Issue 4, 2015, Pages 421-428

  Liu, Xin Yu ^a,b   Zhou, Xin Yu ^c   Hou, Jin Cai ^a   Zhu, Hua ^c   Wang, Zhong ^d   Liu, Jian Xun ^a   Zheng, Yong Qiu ^a,c  

^a XIYUAN HOSPITAL   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c OHIO STATE UNIVERSITY   (United States)

^d INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Akt; BDNF; cerebral ischemia; ERK; ginsenoside Rd; LY294002; neurogenesis; stroke; VEGF

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BRAIN DERIVED NEUROTROPHIC FACTOR; GINSENOSIDE RD; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NESTIN; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN; GINSENOSIDE; VASCULOTROPIN A;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL VIABILITY; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PC12 CELL LINE; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; WESTERN BLOTTING; ANIMAL; BRAIN; CHEMISTRY; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; METABOLISM; PANAX; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; GINSENOSIDES; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MAP KINASE SIGNALING SYSTEM; NEUROGENESIS; PANAX; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84926347182     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.156     Document Type: Article

References (21)

1. Gaulden J, Reiter JF. Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells. Hum Mol Genet 2008; 17: 60-6.
2. Zhao J, Zhao Y, Zheng W, Lu Y, Feng G, Yu S. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res 2008; 1229: 224-32.
3. Sugiura S, Kitagawa K, Tanaka S, Todo K, Matsuoka EO, Sasaki T, et al. Adenovirus-mediated gene transfer of heparin-binding Epidermal growth factor-like growth factor enhances neurogenesis and angiogenesis after focal cerebral ischemia in rats. Stroke 2005; 36: 859-64.
4. Chen Y, Sun FY. Age-related decrease of striatal neurogenesis is associated with apoptosis of neural precursors and newborn neurons in rat brain after ischemia. Brain Res 2007; 1166: 9-19.
5. Radad K, Gille G, Liu L, Rausch WD. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 2006; 100: 175-86.
6. Shang YH, Tian JF, Hou M, Xu XY. Progress on the protective effect of compounds from natural medicines on cerebral ischemia. Chin J Nat Med 2013; 11: 588-95.
7. Ye RD, Kong XW, Yang QZ, Zhang YX, Han JL, Li P, et al. Ginsenoside Rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window. Neurotherapeutics 2011; 8: 515-25.
8. Wang YM, Jin KL, Mao XO, Xie L, Banwait S, Marti HH, et al. VEGF-Overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. J Neurosci Res 2007; 85: 740-7.
9. Rosell A, Morancho A, Navarro-Sobrino M, Mar tinez-Saez E, Hernández-Guillamon M, Lope-Piedrafita S, et al. Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in mice. PLoS One 2013; 8: e73244.
10. Schäbitz WR, Schwab S, Spranger M, Hacke W. Intraventricular brainderived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. Cereb Blood Flow Metab 1997; 17: 500-6.
11. Kim YR, Kim HN, Ahn SM, Choi YH, Shin HK, Choi BT. Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia. PLoS One 2014; 9: e90000.
12. Sun FY, Guo X. Molecular and cellular mechanism of neuroprotection by vascular endothelial growth factor. J Neurosci Res 2005; 79: 180-4.
13. Yan XB, Hou HL, Wu LM, Liu J, Zhou JN. Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia. Neuropharmacology 2007; 53: 487-95.
14. Zhang X, Shi M, Bjørås M, Wang W, Zhang GY, Han JL, et al . Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways. Pharmacology 2013; 4: 1-8.
15. Hoehn BD, Palmer TD, Steinberg GK. Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke 2005; 36: 2718-24.
16. Chen XH, Chen SQ, Jiang Y, Zhu CS, Wu AM, Ma XM, et al. Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin b1 and phosphorylated Akt modulation. Neurol Sci 2013; 34: 1391-6.
17. Tabakman R, Jiang H, Shahar I, Arien-zakay H, Levine RA, Lazarovici P. Neuroprotection by NGF in the PC12 in vitro OGD model involvement of mitogen-activated protein kinases and gene expression. N Y Acad Sci 2005; 1053: 84-96.
18. Saraswati S, Kumar S, Alhaider AA. α-Santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway. Mol Cancer 2013; 147: 1-18.
19. Shin HY, Kim JH, Phi JH, Park CK, Kim JE, Kim JH, et al. Endogenous Neurogenesis and neovascularization in the neocortex of the rat after focal cerebral ischemia. J Neurosci Res 2008; 86: 356-7.
20. Wang Y, Galvan V, Gorostiza O, Ataie M, Jin K, Greenberg DA. Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat. Brain Res 2006; 1115: 186-93.
21. Bramham CR, Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 2005; 76: 99-125.