Curcumin Inhibits TLR2/4-NF-κB Signaling Pathway and Attenuates Brain Damage in Permanent Focal Cerebral Ischemia in Rats

Inflammation

Volumn 37, Issue 5, 2014, Pages 1544-1551

  Tu, Xian kun ^a   Yang, Wei zhong ^a   Chen, Jian ping ^a   Chen, Yan ^a   Ouyang, Long qiang ^a   Xu, Yi chao ^a   Shi, Song sheng ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

cerebral ischemia; curcumin; inflammation; interleukin 1 ; myeloperoxidase; nuclear factor kappa B; toll like receptors; tumor necrosis factor

Indexed keywords

CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MYELOPEROXIDASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TLR2 PROTEIN, RAT; TLR4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN DAMAGE; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WATER CONTENT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BRAIN ISCHEMIA; CURCUMIN; MALE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84918824453     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-9881-6     Document Type: Article

References (23)

1. Dirnagl, U., C. Iadecola, and M.A. Moskowitz. 1999. Pathobiology of ischaemic stroke: an integrated view. Trends in Neurosciences 22: 391–397.
2. Cuartero, M.I., I. Ballesteros, A. Moraga, F. Nombela, J. Vivancos, J.A. Hamilton, Á.L. Corbí, I. Lizasoain, and M.A. Moro. 2013. N2 neutrophils, novel players in brain inflammation after stroke: modulation by the PPARγ agonist rosiglitazone. Stroke 44: 3498–3508.
3. Liesz, A., W. Zhou, S.Y. Na, G.J. Hämmerling, N. Garbi, S. Karcher, E. Mracsko, J. Backs, S. Rivest, and R. Veltkamp. 2013. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. Journal of Neuroscience 33: 17350–17362.
4. Hoffmann, O., J.S. Braun, D. Becker, A. Halle, D. Freyer, E. Dagand, E. Dagand, S. Lehnardt, and J.R. Weber. 2007. TLR2 mediates neuroinflammation and neuronal damage. Journal of Immunology 178: 6476–6481.
5. Ziegler, G., D. Harhausen, C. Schepers, O. Hoffmann, C. Rohr, V. Prinz, J. König, H. Lehrach, W. Nietfeld, and G. Trendelenburg. 2007. TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochemical and Biophysical Research Communications 359: 574–579.
6. Caso, J.R., J.M. Pradillo, O. Hurtado, P. Lorenzo, M.A. Moro, and I. Lizasoain. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115: 1599–1608.
7. Tang, S.C., T.V. Arumugam, X. Xu, A. Cheng, M.R. Mughal, D.G. Jo, J.D. Lathia, D.A. Siler, S. Chigurupati, X. Ouyang, T. Magnus, S. Camandola, and M.P. Mattson. 2007. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proceedings of the National Academy of Sciences of the United States of America 104: 13798–13803.
8. Tu, X.K., W.Z. Yang, S.S. Shi, C.H. Wang, G.L. Zhang, T.R. Ni, C.M. Chen, R. Wang, J.W. Jia, and Q.M. Song. 2010. Spatio-temporal distribution of inflammatory reaction and expression of TLR2/4 signaling pathway in rat brain following permanent focal cerebral ischemia. Neurochemical Research 35: 1147–1155.
9. Lan, L., J. Tao, A. Chen, G. Xie, J. Huang, J. Lin, J. Peng, and L. Chen. 2013. Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-κB pathway. International Journal of Molecular Medicine 31: 75–80.
10. Barakat, W., N. Safwet, N.N. El-Maraghy, and M.N. Zakaria. 2014. Candesartan and glycyrrhizin ameliorate ischemic brain damage through downregulation of the TLR signaling cascade. European Journal of Pharmacology 724: 43–50.
11. Karikó, K., D. Weissman, and F.A. Welsh. 2004. Inhibition of toll-like receptor and cytokine signaling—a unifying theme in ischemic tolerance. Journal of Cerebral Blood Flow and Metabolism 24: 1288–1304.
12. Giordano, S., V. Darley-Usmar, and J. Zhang. 2013. Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biology 2: 82–90.
13. Ahmad, N., S. Umar, M. Ashafaq, M. Akhtar, Z. Iqbal, M. Samim, and F.J. Ahmad. 2013. A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke. Protoplasma 250: 1327–1338.
14. Wu, J., Q. Li, X. Wang, S. Yu, L. Li, X. Wu, Y. Chen, J. Zhao, and Y. Zhao. 2013. Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway. PLoS One 8: e59843.
15. Shi, S.S., W.Z. Yang, X.K. Tu, C.H. Wang, C.M. Chen, and Y. Chen. 2013. 5-Lipoxygenase inhibitor zileuton inhibits neuronal apoptosis following focal cerebral ischemia. Inflammation 36: 1209–1217.
16. Bederson, J.B., L.H. Pitts, M. Tsuji, M.C. Nishimura, R.L. Davis, and H. Bartkowski. 1986. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17: 472–476.
17. Lin, T.N., Y.Y. He, G. Wu, M. Khan, and C.Y. Hsu. 1993. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24: 117–121.
18. Yang, C., X. Zhang, H. Fan, and Y. Liu. 2009. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Research 1282: 133–141.
19. Zhao, J., S. Yu, W. Zheng, G. Feng, G. Luo, L. Wang, and Y. Zhao. 2010. Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Neurochemical Research 35: 374–379.
20. Wang, Y.F., Y.T. Gu, G.H. Qin, L. Zhong, and Y.N. Meng. 2013. Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells. Journal of Molecular Neuroscience 51: 344–351.
21. Singh, R., J. Bullard, M. Kalra, S. Assefa, A.K. Kaul, K. Vonfeldt, S.C. Strom, R.S. Conrad, H.L. Sharp, and R. Kaul. 2011. Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers. Clinical Immunology 138: 41–49.
22. Li, H.Y., Z.Y. Yuan, Y.G. Wang, H.J. Wan, J. Hu, Y.S. Chai, F. Lei, D.M. Xing, and L.J. Du. 2012. Role of baicalin in regulating Toll-like receptor 2/4 after ischemic neuronal injury. Chinese Medical Journal 125: 1586–1593.
23. Tu, X.K., W.Z. Yang, S.S. Shi, Y. Chen, C.H. Wang, C.M. Chen, and Z. Chen. 2011. Baicalin inhibits TLR2/4 signaling pathway in rat brain following permanent cerebral ischemia. Inflammation 34: 463–470.