Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis

Brain Research Bulletin

Volumn 90, Issue 1, 2013, Pages 43-51

  Campbell, Anna M ^a   Zagon, Ian S ^a   McLaughlin, Patricia J ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Astrogliosis; Endogenous opioids; Methionine enkephalin; Multiple sclerosis

Indexed keywords

DNA; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; NITRIC OXIDE; OPIOID GROWTH FACTOR; OPIOID GROWTH FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL COUNT; CELL CYCLE PHASE; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; CELL PROLIFERATION; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALIN, METHIONINE; FEMALE; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NARCOTIC ANTAGONISTS; NECROSIS; NITRIC OXIDE; PEPTIDES; RECEPTORS, OPIOID; RNA, SMALL INTERFERING; TIME FACTORS;

EID: 84870497154     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2012.09.001     Document Type: Article

References (26)

1. Campbell A.M., Zagon I.S., McLaughlin P.J. Opioid growth factor arrests the progression of clinical disease and spinal cord pathology in established experimental autoimmune encephalomyelitis. Brain Research 2012, 1472:138-148.
2. Donahue R.N., McLaughlin P.J., Zagon I.S. Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis. American Journal of Physiology 2009, 296:R1716-R1725.
3. Eriksson P.S., Hansson E., Ronnback L. Mu and delta opiate receptors in neuronal and astroglial primary cultures from various regions of the brain-coupling with adenylate cyclase, localization on the same neurones, and associate with dopamine (D1) receptor adenylate cyclase. Neuropharmacology 2001, 30:1233-1239.
4. Hauser K.F., Osborne J.G., Steine-Martin A., Melner M.H. Cellular localization of proenkephalin mRNA and enkephalin peptide products in cultured astrocytes. Brain Research 1990, 522:347-353.
5. Kawasaki T., Kitao T., Nakagawa K., Fujisaki H., Takegawa Y., Koda K., Ago Y., Baba A., Matsuda T. Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radial scavenger. Glia 2007, 55:1325-1333.
6. Liedtke W., Edelmann W., Chiu F.C., Kucherlapati R., Raine C.S. Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. American Journal of Physiology 1998, 152:251-259.
7. Nishio T., Kawaguchi S., Yamamoto M., Iseda T., Kawasaki T., Hase T. Tenascin-C regulates proliferation and migration of cultured astrocytes in a scratch wound assay. Neuroscience 2005, 132:87-102.
8. Pahan K., Sheikh F.G., Namboodiri A.M.S., Singh I. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. Journal of Clinical Investigation 1997, 100:2671-2679.
9. Pekny M., Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434.
10. Persson P.A.I., Thorlin T., Ronnback L., Hansson E., Eriksson P.S. Differential expression of delta opioid receptors and mRNA in proliferating astrocytes during the cell cycle. Journal of Neuroscience Research 2000, 61:371-375.
11. Rahn K.A., McLaughlin P.J., Zagon I.S. Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF) for an extended period: Therapeutic implications for multiple sclerosis. Brain Research 2011, 1381:243-253.
12. Ruzicka B.B., Fox C.A., Thompson R.C., Meng F., Watson S.J., Akil H. Primary astroglial cultures derived from several rat brain regions differentially express μ, δ, and κ opioid receptor mRNA. Molecular Brain Research 1995, 34:209-220.
13. Shinoda H., Marini A.M., Cosi C., Schwartz J.P. Brain region and gene specificity of neuropeptide gene expression in cultured astrocytes. Science 1989, 245:415-417.
14. Soos J.M., Morrow J., Ashley T.A., Szente B.E., Bikoff E.K., Zamvil S.S. Astrocytes express elements of the class II endocytotic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells. Journal of Immunology 1998, 161:5959-5966.
15. Steine-Martin A., Zhou R., Hauser K.F. Regional, developmental, and cell cycle-dependent differences in μ, δ, and κ-opioid receptor expression among cultured mouse astrocytes. Glia 1998, 22:249-259.
16. Thorlin T., Anders P., Persson I., Eriksson P.S., Hansson E., Ronnback L. Delta-opioid receptor immunoreactivity on astrocytes is upregulated during mitosis. Glia 1999, 25:370-378.
17. Weir C., McNeill A., Hook S., Harvie M., La Flamme A.C., Le Gros G., Backstrom B.T. Critical role of preproenkephalin in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 2006, 179:18-25.
18. Yu A.C.H., Lee Y.L., Eng L.F. Astrogliosis in culture: I. The model and the effect of antisense oligonucleotides on glial fibrillary acidic protein synthesis. Journal of Neuroscience Research 1993, 34:295-303.
19. Zagon I.S., McLaughlin P.J. Production and characterization of polyclonal and monoclonal antibodies to the zeta opioid receptor. Brain Research 1993, 630:295-302.
20. Zagon I.S., Donahue R.N., McLaughlin P.J. Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers. American Journal of Physiology 2009, 297:R1154-R1161.
21. Zagon I.S., Donahue R.N., Bonneau R.H., McLaughlin P.J. B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication of the treatment of autoimmune diseases. Immunobiology 2011, 216:173-183.
22. 5]-enkephalin)-opioid growth factor receptor axis: implication for the treatment of autoimmune diseases. Immunobiology 2011, 216:579-590.
23. Zagon I.S., Rahn K.A., McLaughlin P.J. Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells. Neuropeptides 2007, 41:441-452.
24. Zagon I.S., Rahn K.A., Bonneau R.H., Turel A.P., McLaughlin P.J. Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis. Brain Research 2010, 1310:154-161.
25. Zeinstra E., Wilczak N., Streefland C., DeKeyse J. Astrocytes in chronic active multiple sclerosis plaques express MHC class II molecules. Neuroreport 2000, 11:89-91.
26. Zwain I.H., Yen S.S.C. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 1999, 140:3843-3852.