Anti-inflammation effects of picroside 2 in cerebral ischemic injury rats

Behavioral and Brain Functions

Volumn 6, Issue , 2010, Pages

  Guo, Yunliang ^a   Xu, Xinying ^a   Li, Qin ^a,b   Li, Zhen ^a,c   Du, Fang ^a  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b YANTAI YUHUANGDING HOSPITAL   (China)

^c Anhui Chest Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PICROSIDE 2; PLANT GLYCOSIDE; SALVIANIC ACID A SODIUM; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CAFFEIC ACID DERIVATIVE; CINNAMIC ACID DERIVATIVE; GLUCOSIDE; LACTIC ACID DERIVATIVE; PICROSIDE II; SALVIANOLIC ACID A; TLR4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN TISSUE; COGNITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; MIDDLE CEREBRAL ARTERY OCCLUSION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; ANIMAL; BRAIN; CEREBRAL ARTERY DISEASE; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; ENCEPHALITIS; METABOLISM; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; RANDOMIZATION; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; CAFFEIC ACIDS; CINNAMATES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; FEMALE; GLUCOSIDES; INFARCTION, MIDDLE CEREBRAL ARTERY; LACTATES; NEUROPSYCHOLOGICAL TESTS; NF-KAPPA B; RANDOM ALLOCATION; RATS; RATS, WISTAR; REPERFUSION INJURY; TOLL-LIKE RECEPTOR 4; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954322948     PISSN: 17449081     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-9081-6-43     Document Type: Article

References (32)

1. Kaushal V, Schlichter LC. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 2008, 28:2221-2230. 10.1523/JNEUROSCI.5643-07.2008, 18305255.
2. Caso JR, Pradillo JM, Hurtado O, Leza JC, Moro MA, Lizasoain I. Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. Stroke 2008, 39:1314-1320. 10.1161/STROKEAHA.107.498212, 18309167.
3. Bi X, Yan B, Fang S. Quetiapine regulates neurogenesis in ischemic mice by inhibiting NF-kappaB p65/p50 expression. Neurol Res 2009, 31:159-166. 10.1179/174313209X393573, 19298756.
4. Stuppner H, Wagner H. New cucurbitacin glycosidesfrom Picrorhiza Kurrooa. Planta Medica 1989, 55:559-563. 10.1055/s-2006-962095, 2616673.
5. Wang DQ, He ZD, Feng BS. Chemical constituents from Picrorhiza scrophulariflora. Acta Botanica Yunnanica 1993, 15:83-88.
6. Liu J, Liu BL, Zhang JQ, Zhang N. Hepatoprotective and choleretic action of Picrorhiza scrophulariae flora Pennell. Chin J New Drugs 2002, 11:459-461.
7. Li T, Liu JW, Zhang XD, Guo MC, Ji G. The neuroprotective effect of picroside 2 from hu-huang-lian against oxidtive stress. Am J Chin Med 2007, 35:681-691. 10.1142/S0192415X0700517X, 17708634.
8. Liu JW, Yu YJ, Zheng PY, Zhang XD, Li T, Cao Y, Guo MC. Synergistic protective effect of picroside 2 and NGF on PC12 cells against oxidative stress induced by H2O2. Pharmacol Rep 2007, 59:573-579.
9. He LJ, Liang M, Hou FF, Guo ZJ, Xie D, Zhang X. Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action. J Endocrinol 2009, 200(3):347-355. 10.1677/JOE-08-0481, 19066289.
10. Li P, Matsunaga K, Yamakuni T, Ohizumi Y. Potentiation of nerve growth factor-action by picrosides 1 and 2, natural iridoids, in PC12D cells. Eur J Pharmacol 2000, 406:203-208. 10.1016/S0014-2999(00)00662-2, 11020482.
11. Li P, Matsunaga K, Yamakuni T, Ohizumi Y. Picrosides 1 and 2, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells. Life Sci 2002, 71:1821-1835. 10.1016/S0024-3205(02)01949-5, 12151059.
12. Tao YW, Liu JW, Wei DZ, Su W, Zhou WY. Protective effect of picroside 2 on the damage of culture PC12 cells in vitro. Chin J Clin Pharmacol Ther 2003, 8:27-30.
13. Guo MC, Cao Y, Liu JW. Protective effects of picroside 2 on glutamate injury of PC12 cells. Chin J Clin Pharmacol Ther 2007, 12:440-443.
14. Yin JJ, Zhang W, Du F. Effects of extraction of Huhuanglian on apoptosis and Bcl-2 gene in penumbra area in ischemia reperfusion rats. Shandong J Traditil Chin Med 2005, 24:364-366.
15. Yang XW, Ji XM, Guo YL, Du F. Effect of rhizoma picrorhizae on nerve growth factor in rat brain following cerebral ischemia. Acta Acad Med Qingdao University 2008, 44:69-71.
16. Yan WJ, Li Z, Wang HP, Shen W, Du F. Picroside 2 inhibit apoptosis and expressions of iNOS following cerebral ischemic reperfusion injury in rats. Chin Pharmacol Bull 2009, 25:1677-1678.
17. Li Z, Xu XY, Shen W, Guo YL. The interferring effects of picroside 2 on the expressions of NF-κB and I-κB following cerebral ischemia reperfusion injury in rats. Chin Pharmacol Bull 2010, 26:52-56.
18. Li Q, Guo YL, Li Z, Xu XY. The interference of picroside 2 on the expressions of Caspase-3 and PARP following cerebral ischemia reperfusion injury in rats. Chin Pharmacol Bull 2010, 26:342-345.
19. Li Z, Li Q, Guo YL, Qin LH, Luan LJ. The interference effect of picroside 2 on cerebral ischemia reperfusion injury in rats. Acta Anat Sinica 2010, 41:9-12.
20. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
21. Gao HM, Zhang MZ. Asymmetry in the brain influenced the neurological deficits and infarction volume following the middle cerebral artery occlusion in rats. Behavioral and Brain Functions 2008, 4:57-61. 10.1186/1744-9081-4-57, 2621224, 19102754.
22. Chinese Pharmcopoeia Commission Chinese Pharmacopoeia, Part 1. 2005 ed. 2005, 212-213. Beijing: Chemical Industry Press, Chinese Pharmcopoeia Commission.
23. Xiao YJ, Jiang ZZ, Yao JC, Huang X, Huang JF, Wang T, Zhang LY. Investigation of picroside 2's impacts on the P450 activities using a cocktail method. Chin J Nat Med 2008, 6:292-297.
24. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986, 17:472-476.
25. Hua F, Ma J, Ha T, Kelley JL, Kao RL, Schweitzer JB, Kalbfleisch JH, Williams DL, Li C. Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia reperfusion injury in mice. Brain Res 2009, 1262:100-108. 10.1016/j.brainres.2009.01.018, 2722683, 19401158.
26. Yang QW, Li JC, Lu FL, Wen AQ, Xiang J, Zhang LL, Huang ZY, Wang JZ. Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction. J Cereb Blood Flow Metab 2008, 28:1588-1596. 10.1038/jcbfm.2008.50, 18523439.
27. Boersma MC, Meffert MK. Novel roles for the NF-kappaB signaling pathway in regulating neuronal function. Sci Signal 2008, 1:pe7. 10.1126/stke.16pe7, 18272467.
28. Lou HY, Wei XB, Zhang B, Sun X, Zhang XM. Hydroxyethylpuerarin attenuates focal cerebral ischemia-reperfusion injury in rats by decreasing TNF-α expression and NFκB activity. Acta Pharmaceutica Sinica 2007, 42:710-715.
29. Liu Y, Zhang XJ, Yang CH, Fan HG. Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-κB expression. Brain Res 2009, 1268:174-180. 10.1016/j.brainres.2009.02.069, 19285049.
30. Webster CM, Kelly S, Koike MA, Chock VY, Giffard RG, Yenari MA. Inflammation and NF-κB activation is decreased by hypothermia following global cerebral ischemia. Neurobiol Dis 2009, 33:301-312. 10.1016/j.nbd.2008.11.001, 2737398, 19063968.
31. Zhang HL, Gu ZL, Savitz SI, Han F, Fukunaga K, Qin ZH. Neuroprotective effects of prostaglandin A in rat models of permanent focal cerebral ischemia are associated with nuclear factor-kappaB inhibition and peroxisome proliferator activated receptor-gamma up-regulation. J Neurosci Res 2008, 86:1132-1141. 10.1002/jnr.21569, 18074385.
32. Li Z, Xu XY, Li Q, Zhang MZ, Shen W. Protective mechanisms of picroside 2 on aquaporin-4 expression in rat model of cerebral ischemia/reperfusion injury. Neural Regen Res 2010, 5:411-417.