Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status

European Journal of Nutrition

Volumn 56, Issue 2, 2017, Pages 621-634

  Seibert, Eric ^a   Lehmann, Ulrike ^a   Riedel, Annett ^a   Ulrich, Christof ^a   Hirche, Frank ^a   Brandsch, Corinna ^a   Dierkes, Jutta ^b   Girndt, Matthias ^a   Stangl, Gabriele I ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

Adults; Cardiovascular risk; Monocyte subsets; Supplementation; Vitamin D3

Indexed keywords

ALDOSTERONE; CALCIFEDIOL; COLECALCIFEROL; LIPID; PLACEBO; RENIN; VITAMIN D; BIOLOGICAL MARKER;

ADULT; AGED; ALDOSTERONE BLOOD LEVEL; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL CALCIFICATION; CARDIOVASCULAR RISK; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GENE EXPRESSION; GERMANY; HEART RATE; HUMAN; INFLAMMATION; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MONOCYTE; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; BLOOD; CARDIOVASCULAR DISEASES; COMPLICATION; DIETARY SUPPLEMENT; MIDDLE AGED; NUTRITIONAL STATUS; SEASON; VITAMIN D DEFICIENCY;

ADULT; AGED; BIOMARKERS; BLOOD PRESSURE; CALCIFEDIOL; CARDIOVASCULAR DISEASES; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GERMANY; HUMANS; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PLACEBOS; RISK FACTORS; SEASONS; VITAMIN D DEFICIENCY;

EID: 84948949582     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-1106-8     Document Type: Article

References (52)

1. Kühn T, Kaaks R, Teucher B, Hirche F, Dierkes J, Weikert C, Katzke V, Boeing H, Stangl GI, Buijsse B (2013) Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident myocardial infarction and stroke in the European prospective investigation into cancer and nutrition (EPIC)-Germany study. PLoS ONE 8:e69080
2. Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, Lundqvist A, Jassal SK, Barrett-Connor E, Zhang C, Eaton CB, May HT, Anderson JL, Sesso HD (2012) Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes 5:819–829
3. Schöttker B, Jorde R, Peasey A, Thorand B, Jansen EH, Groot Ld, Streppel M, Gardiner J, Ordóñez-Mena JM, Perna L, Wilsgaard T, Rathmann W, Feskens E, Kampman E, Siganos G, Njølstad I, Mathiesen EB, Kubínová R, Pająk A, Topor-Madry R, Tamosiunas A, Hughes M, Kee F, Bobak M, Trichopoulou A, Boffetta P, Brenner H (2014) Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ 348:g3656
4. Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, Khan H, Baena CP, Prabhakaran D, Hoshen MB, Feldman BS, Pan A, Johnson L, Crowe F, Hu FB, Franco OH (2014) Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ 348:g1903
5. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP (2002) 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110:229–238
6. Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS (2014) Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology 146:1048–1059
7. Schmidt N, Brandsch C, Kühne H, Thiele A, Hirche F, Stangl GI (2012) Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice. PLoS ONE 7:e35316
8. Schmidt N, Brandsch C, Schutkowski A, Hirche F, Stangl GI (2014) Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice. J Nutr 144:638–646
9. Müller K, Haahr PM, Diamant M, Rieneck K, Kharazmi A, Bendtzen K (1992) 1,25-Dihydroxyvitamin D3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokine 4:506–512
10. Deluca HF, Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15:2579–2585
11. Girndt M, Seibert E (2010) Premature cardiovascular disease in chronic renal failure (CRF): a model for an advanced ageing process. Exp Gerontol 45:797–800
12. Witham MD, Dove FJ, Dryburgh M, Sugden JA, Morris AD, Struthers AD (2010) The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial. Diabetologia 53:2112–2119
13. Jorde R, Sneve M, Torjesen P, Figenschau Y (2010) No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med 267:462–472
14. Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer R (2009) Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 89:1321–1327
15. Wood AD, Secombes KR, Thies F, Aucott L, Black AJ, Mavroeidi A, Simpson WG, Fraser WD, Reid DM, Macdonald HM (2012) Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT. J Clin Endocrinol Metab 97:3557–3568
16. Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R (2006) Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 83:754–759
17. Arora P, Song Y, Dusek J et al (2015) Vitamin D therapy in individuals with prehypertension or hypertension: the DAYLIGHT trial. Circulation 131:254–262
18. Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M; RECORD Trial Group (2014) Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis. Am J Clin Nutr 100:746–755
19. German Nutrition Society (2012) New reference values for vitamin D. Ann Nutr Metab 60:241–246
20. Hintzpeter B, Mensink GBM, Thierfelder W, Müller MJ, Scheidt-Nave C (2008) Vitamin D status and health correlates among German adults. Eur J Clin Nutr 62:1079–1089
21. Kühn T, Kaaks R, Teucher B, Hirche F, Dierkes J, Weikert C, Katzke V, Boeing H, Stangl GI, Buijsse B (2014) Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Eur J Nutr 53:731–741
22. Brown J, Ignatius A, Amling M, Barvencik F (2013) New perspectives on vitamin D sources in Germany based on a novel mathematical bottom-up model of 25(OH)D serum concentrations. Eur J Nutr 52:1733–1742
23. 3 metabolites—a randomized controlled trial. Clin Nutr. doi:10.1016/j.clnu.2015.04.021
24. Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97:1837–1847
25. Brenner D, Blaser H, Mak TW (2015) Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol 15:362–374
26. Sabroe I, Dower SK, Whyte MK (2010) The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis 41(Suppl 7):S421–S426
27. Sabat R, Grütz G, Warszawska K, Kirsch S, Witte E, Wolk K, Geginat J (2010) Biology of interleukin-10. Cytokine Growth Factor Rev 21:331–344
28. Ley K, Miller YI, Hedrick CC (2011) Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol 31:1506–1516
29. Heine GH, Ulrich C, Seibert E, Seiler S, Marell J, Reichart B, Krause M, Schlitt A, Köhler H, Girndt M (2008) CD14(++)CD16 + monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients. Kidney Int 73:622–629
30. Ulrich C, Heine GH, Seibert E, Fliser D, Girndt M (2010) Circulating monocyte subpopulations with high expression of angiotensin conversion enzyme predict mortality in patients with end-stage renal disease. Nephrol Dial Transplant 25:2265–2272
31. 3 in healthy volunteers, a randomized placebo-controlled trial. J Clin Endocrinol Metab 98:4339–4345
32. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
33. Nybo M, Rasmussen LM (2008) The capability of plasma osteoprotegerin as a predictor of cardiovascular disease: a systematic literature review. Eur J Endocrinol 159:603–608
34. Quercioli A, Montecucco F, Bertolotto M, Ottonello L, Pende A, Mach F, Dallegri F (2010) Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling. Eur J Clin Invest 40:645–654
35. Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB (2012) Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol 32:613–622
36. Wang L, Hu XB, Zhang W, Wu LD, Liu YS, Hu B, Bi CL, Chen YF, Liu XX, Ge C, Zhang Y, Zhang M (2013) Dickkopf-1 as a novel predictor is associated with risk stratification by GRACE risk scores for predictive value in patients with acute coronary syndrome: a retrospective research. PLoS ONE 8:e54731
37. Fry CM, Sanders TA (2015) Vitamin D and risk of CVD: a review of the evidence. Proc Nutr Soc 20:1–13
38. Wang L, Chu A, Buring JE, Ridker PM, Chasman DI, Sesso HD (2014) Common genetic variations in the vitamin D pathway in relation to blood pressure. Am J Hypertens Adv Access 27:1387–1395
39. Wang H, Xia N, Yang Y, Peng D (2012) Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis 11:42
40. Challoumas D (2014) Vitamin D supplementation and lipid profile: what does the best available evidence show? Atherosclerosis 236:130–139
41. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A, Levine B, Mehrotra R, Norris K (2007) Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 167:1159–1165
42. Zittermann A, Koerfer R (2008) Protective and toxic effects of vitamin D on vascular calcification: clinical implications. Mol Aspects Med 29:423–432
43. Young KA, Snell-Bergeon JK, Naik RG, Hokanson JE, Tarullo D, Gottlieb PA, Garg SK, Rewers M (2011) Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. Diabetes Care 34:454–458
44. Shroff R, Egerton M, Bridel M, Shah V, Donald AE, Cole TJ, Hiorns MP, Deanfield JE, Rees L (2008) A bimodal association of vitamin D levels and vascular disease in children on dialysis. J Am Soc Nephrol 19:1239–1246
45. Raaz U, Schellinger IN, Chernogubova E et al (2015) Transcription factor Runx2 promotes aortic fibrosis and stiffness in type 2 diabetes mellitus. Circ Res 117:513–524
46. Grubczak K, Lipinska D, Eljaszewicz A, Singh P, Radzikowska U, Miklasz P, Dabrowska M, Jablonska E, Bodzenta-Lukaszyk A, Moniuszko M (2015) Vitamin D3 treatment decreases frequencies of CD16-positive and TNF-α-secreting monocytes in asthmatic patients. Int Arch Allergy Immunol 166:170–176
47. Seibert E, Heine GH, Ulrich C, Seiler S, Köhler H, Girndt M (2013) Influence of cholecalciferol supplementation in hemodialysis patients on monocyte subsets: a randomized, double-blind, placebo-controlled clinical trial. Nephron Clin Pract 123:209–219
48. Lucisano S, Di Mauro E, Montalto G, Cernaro V, Buemi M, Santoro D (2014) Vitamin D and anemia. J Ren Nutr 24:61–62
49. Saab G, Young DO, Gincherman Y, Giles K, Norwood K, Coyne DW (2007) Prevalence of vitamin D deficiency and the safety and effectiveness of monthly ergocalciferol in hemodialysis patients. Nephron Clin Pract 105:c132–c138
50. Lac PT, Choi K, Liu IA, Meguerditchian S, Rasgon SA, Sim JJ (2010) The effects of changing vitamin D levels on anemia in chronic kidney disease patients: a retrospective cohort review. Clin Nephrol 74:25–32
51. Lang E, Jilani K, Bissinger R, Rexhepaj R, Zelenak C, Lupescu A, Lang F, Qadri SM (2015) Vitamin D-rich diet in mice modulates erythrocyte survival. Kidney Blood Press Res 40:403–412
52. Ross AC, Taylo CL, Yaktine AL, Valle HB (2011) Dietary reference intakes for calcium and vitamin D: Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. The National Academies Collection: Reports funded by National Institutes of Health