No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year: Original Article

Journal of Internal Medicine

Volumn 267, Issue 5, 2010, Pages 462-472

  Jorde, R ^a,b   Sneve, M ^b   Torjesen, P ^c   Figenschau, Y ^a,b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c AKER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Blood pressure control; Glucose metabolism; Lipids; Obesity; Vitamins

Indexed keywords

CALCIUM; COLECALCIFEROL; DECRISTOL; GLUCOSE; LIPID; NYCOPLUS CALCIUM; PLACEBO; UNCLASSIFIED DRUG; VITAMIN D;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NORWAY; OBESITY; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TREATMENT OUTCOME; UNIVERSITY HOSPITAL; VITAMIN SUPPLEMENTATION;

ADULT; AGED; BLOOD GLUCOSE; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CHOLECALCIFEROL; CROSS-SECTIONAL STUDIES; DOUBLE-BLIND METHOD; FASTING; FEMALE; HUMANS; LIPIDS; MALE; MIDDLE AGED; NORWAY; OBESITY; OVERWEIGHT; RISK FACTORS; VITAMINS; YOUNG ADULT;

EID: 77950477106     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2009.02181.x     Document Type: Article

References (39)

1. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004 80 : 1689S 96S.
2. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998 78 : 1193 1231. (Pubitemid 28491953)
3. Snijder MB, van Dam RM, Visser M et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 2005 90 : 4119 4123. (Pubitemid 41058184)
4. Need AG, O'Loughlin PD, Horowitz M, Nordin BE. Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women. Clin Endocrinol 2005 62 : 738 741. (Pubitemid 40825945)
5. Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care 2005 28 : 1228 1230. (Pubitemid 40616645)
6. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 2007 20 : 713 719. (Pubitemid 46936167)
7. Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V. Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2008 87 : 136 141.
8. Hyppönen E, Boucher BJ, Berry DJ, Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008 57 : 298 305.
9. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008 168 : 1174 1180. (Pubitemid 351831400)
10. Dobnig H, Pilz S, Scharnagl H et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med 2008 168 : 1340 1349. (Pubitemid 351930842)
11. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 2008 168 : 1629 1637.
12. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 1995 38 : 1239 1245.
13. de Boer IH, Tinker LF, Connelly S et al. Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative. Diabetes Care 2008 31 : 701 707.
14. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care 2007 30 : 980 986. (Pubitemid 46556596)
15. Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001 86 : 1633 1637. (Pubitemid 32377290)
16. Scragg R, Khaw KT, Murphy S. Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults. Eur J Clin Nutr 1995 49 : 640 646.
17. Zittermann A, Frisch S, Berthold HK et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 2009 89 : 1321 1327.
18. Heikkinen AM, Tuppurainen MT, Niskanen L, Komulainen M, Penttilä I, Saarikoski S. Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy. Eur J Endocrinol 1997 137 : 495 502. (Pubitemid 27505309)
19. Andersen R, Brot C, Mejborn H et al. Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants. Eur J Clin Nutr 2009 63 : 1150 1153.
20. Sneve M, Figenschau Y, Jorde R. Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects. Eur J Endocrinol 2008 159 : 675 684.
21. Kamycheva E, Jorde R, Figenschau Y, Haug E. Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity. J Endocrinol Invest 2007 30 : 126 132. (Pubitemid 46614443)
22. Iqbal A, Jorde R, Figenschau Y. Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromsø Study. J Intern Med 2006 260 : 53 61. (Pubitemid 43894070)
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 : 412 419. (Pubitemid 15018832)
24. Katz A, Nambi SS, Mather K et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000 85 : 2402 2410. (Pubitemid 32269192)
25. Osmancevic A, Nilsen LT, Landin-Wilhelmsen K et al. Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis. J Eur Acad Dermatol Venereol 2009 23 : 1133 1140.
26. Bland R, Markovic D, Hills CE et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 2004 89-90 : 121 125. (Pubitemid 38844271)
27. Maestro B, Campion J, Davila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J 2000 47 : 383 391.
28. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004 79 : 820 825. (Pubitemid 41103882)
29. Mattila C, Knekt P, Männistö S et al. Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 2007 30 : 2569 2570. (Pubitemid 47547796)
30. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006 84 : 18 28. (Pubitemid 44699167)
31. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999 69 : 842 856. (Pubitemid 29205056)
32. Kawashima H. Receptor for 1,25-dihydroxyvitamin D in a vascular smooth muscle cell line derived from rat aorta. Biochem Biophys Res Commun 1987 146 : 1 6.
33. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002 110 : 229 238. (Pubitemid 34787360)
34. Forman JP, Giovannucci E, Holmes MD et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007 49 : 1063 1069. (Pubitemid 351664326)
35. Lind L, Wengle B, Wide L, Ljunghall S. Reduction of blood pressure during long-term treatment with active vitamin D (alphacalcidol) is dependent on plasma renin activity and calcium status. A double-blind, placebo-controlled study. Am J Hypertens 1989 2 : 20 5. (Pubitemid 19031898)
36. Johnson RJ, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Feig DI, Herrera-Acosta J. Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension. Hypertension 2005 45 : 326 330. (Pubitemid 40315796)
37. Reid IR. Effects of calcium supplementation on circulating lipids: potential pharmacoeconomic implications. Drugs Aging 2004 21 : 7 17.
38. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. Regulation of adiposity by dietary calcium. FASEB J 2000 14 : 1132 1138. (Pubitemid 30350395)
39. Finer N, James WP, Kopelman PG, Lean ME, Williams G. One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor. Int J Obes Relat Metab Disord 2000 24 : 306 313. (Pubitemid 30137720)