Vitamin D3 supplementation: Response and predictors of vitamin D3 metabolites - A randomized controlled trial

Clinical Nutrition

Volumn 35, Issue 2, 2016, Pages 351-358

  Lehmann, Ulrike ^a   Riedel, Annett ^a   Hirche, Frank ^a   Brandsch, Corinna ^a   Girndt, Matthias ^a   Ulrich, Christof ^a   Seibert, Eric ^a   Henning, Christian ^a   Glomb, Marcus A ^a   Dierkes, Jutta ^b   Stangl, Gabriele I ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

24,25(OH)2D3; 25(OH)D3; Healthy subjects; Randomized controlled trial; Supplementation; Vitamin D

Indexed keywords

BIOLOGICAL MARKER; CALCIFEDIOL; CALCIUM; COLECALCIFEROL; PHOSPHATE; PLACEBO; SECALCIFEROL; TRIACYLGLYCEROL;

ADULT; AGE; AGED; ARTICLE; BODY WEIGHT; CALCIUM METABOLISM; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PARALLEL DESIGN; PHOSPHATE METABOLISM; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WINTER; BLOOD; BLOOD PRESSURE; BODY MASS; DIETARY SUPPLEMENT; DRUG EFFECTS; MIDDLE AGED; SEASON; WAIST CIRCUMFERENCE; YOUNG ADULT;

24,25-DIHYDROXYVITAMIN D 3; ADULT; AGED; BIOMARKERS; BLOOD PRESSURE; BODY MASS INDEX; CALCIFEDIOL; CALCIUM; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOSPHATES; SEASONS; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 84960486339     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2015.04.021     Document Type: Article

References (30)

1. Ross A.C., Taylo C.L., Yaktine A.L., Valle H.B. Dietary reference intakes for calcium and vitamin D: institute of medicine (US) committee to review dietary reference intakes for vitamin D and calcium 2011, The National Academies Collection: Reports funded by National Institutes of Health.
2. Pludowski P., Holick M.F., Pilz S., Wagner C.L., Hollis B.W., Grant W.B., et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev 2013, 12:976-989.
3. Spedding S., Vanlint S., Morris H., Scragg R. Does vitamin D sufficiency equate to a single serum 25-hydroxyvitamin D level or are different levels required for non-skeletal diseases?. Nutrients 2013, 5:5127-5139.
4. Heaney R.P. Toward a physiological referent for the vitamin D requirement. J Endocrinol Investig 2014, 37:1127-1130.
5. Kühn T., Kaaks R., Teucher B., Hirche F., Dierkes J., Weikert C., et al. Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Eur J Nutr 2014, 53:731-741.
6. German Nutrition Society New reference values for vitamin D. Ann Nutr Metab 2012, 60:241-246.
7. Cashman K.D., Hill T.R., Lucey A.J., Taylor N., Seamans K.M., Muldowney S., et al. Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr 2008, 88:1535-1542.
8. Blum M., Dallal G.E., Dawson-Hughes B. Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults. J Am Coll Nutr 2008, 27:274-279.
9. Didriksen A., Grimnes G., Hutchinson M.S., Kjærgaard M., Svartberg J., Joakimsen R.M., et al. The serum 25-hydroxyvitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels. Eur J Endocrinol 2013, 169:559-567.
10. Waterhouse M., Tran B., Armstrong B.K., Baxter C., Ebeling P.R., English D.R., et al. Environmental, personal, and genetic determinants of response to vitamin D supplementation in older adults. J Clin Endocrinol Metab 2014, 99:E1332-E1340.
11. Saliba W., Barnett-Griness O., Rennert G. The relationship between obesity and the increase in serum 25(OH)D levels in response to vitamin D supplementation. Osteoporos Int 2013, 24:1447-1454.
12. Nelson M.L., Blum J.M., Hollis B.W., Rosen C., Sullivan S.S. Supplements of 20 microg/d cholecalciferol optimized serum 25-hydroxyvitamin D concentrations in 80% of premenopausal women in winter. J Nutr 2009, 139:540-546.
13. Faul F., Erdfelder E., Lang A.-G., Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007, 39:175-191.
14. Schutkowski A., Krämer J., Kluge H., Hirche F., Krombholz A., Theumer T., et al. UVB exposure of farm animals: study on a food-based strategy to bridge the gap between current vitamin D intakes and dietary targets. PLoS One 2013, 8:e69418.
15. 3 in healthy volunteers, a randomized placebo-controlled trial. J Clin Endocrinol Metab 2013, 98:4339-4345.
16. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A., Heaney R.P., et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011, 96:1911-1930.
17. Heaney R.P., Davies K.M., Chen T.C., Holick M.F., Barger-Lux M.J. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003, 77:204-210.
18. 3-24-hydroxylase, a multicatalytic enzyme. Biochemistry 1996, 35:8465-8472.
19. 3 in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults. Am J Clin Nutr 2014, 99:1414-1423.
20. Cipriani C., Romagnoli E., Pepe J., Russo S., Carlucci L., Piemonte S., et al. Long-term bioavailability after a single oral or intramuscular administration of 600,000 IU of ergocalciferol or cholecalciferol: implications for treatment and prophylaxis. J Clin Endocrinol Metab 2013, 98:2709-2715.
21. 3 supplementation. J Steroid Biochem Mol Biol 2011, 126:72-77.
22. Bhattacharyya M.H., DeLuca H.F. The regulation of rat liver calciferol-25-hydroxylase. J Biol Chem 1973, 248:2969-2973.
23. Gallagher J.C., Sai A., Templin T., Smith L. Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med 2012, 156:425-437.
24. 3 supplementation: a meta-regression analysis. Nutrition 2014, 30:975-985. 10.1016/j.nut.2013.12.020.
25. Arunabh S., Pollack S., Yeh J., Aloia J.F. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 2003, 88:157-161.
26. Vimaleswaran K.S., Berry D.J., Lu C., Tikkanen E., Pilz S., Hiraki L.T., et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013, 10:e1001383.
27. Wortsman J., Matsuoka L.Y., Chen T.C., Lu Z., Holick M.F. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000, 72:690-693.
28. Valcour A., Blocki F., Hawkins D.M., Rao S.D. Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels. J Clin Endocrinol Metab 2012, 97:3989-3995.
29. Jorde R., Sundsfjord J., Bønaa K.H. Determinants of serum calcium in men and women. The Tromsø Study. Eur J Epidemiol 2001, 17:1117-1123.
30. 3 and phosphorus in vivo. J Biol Chem 2005, 280:2543-2549.