Hypothalamic GLP-1: The control of BAT thermogenesis and browning of white fat

Adipocyte

Volumn 4, Issue 2, 2015, Pages 141-145

  López, Miguel ^a,b   Diéguez, Carlos ^a,b   Nogueiras, Rubén ^a,b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Brown adipose tissue; GLP 1; Hypothalamus; Sympathetic nervous system

Indexed keywords

BONE MORPHOGENETIC PROTEIN; ESTRADIOL; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INCRETIN; LEPTIN; LIRAGLUTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; STEROIDOGENIC FACTOR 1; THYROID HORMONE; UNCOUPLING PROTEIN 1;

ARCUATE NUCLEUS; ARTICLE; BLOOD PRESSURE; BODY MASS; BROWN ADIPOSE TISSUE; ENERGY EXPENDITURE; FATTY LIVER; GENE EXPRESSION; GLUCOSE METABOLISM; GLYCATION; HUMAN; HYPOTHALAMUS; INFERIOR OLIVE; INSULIN RESPONSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; SIGNAL TRANSDUCTION; THERMOGENESIS; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

EID: 84948774202     PISSN: 21623945     EISSN: 2162397X     Source Type: Journal    
DOI: 10.4161/21623945.2014.983752     Document Type: Article

References (86)

1. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 2000; 404:652-60;
2. PMID:10766252
3. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009; 360:1500-8;
4. PMID:19357405; http://dx.doi.org/10.1056/NEJMoa0808718
5. Tran TT, Kahn CR. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol 2010; 6:195-213;
6. PMID:20195269; http:// dx.doi.org/10.1038/nrendo.2010.20
7. Whittle AJ, Lopez M, Vidal-Puig A. Using brown adipose tissue to treat obesity-the central issue. Trends Mol Med 2011; 17:405-11;
8. PMID:21602104
9. Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 2009; 23:3113-20;
10. PMID:19417078; http://dx.doi.org/10.1096/fj.09- 133546
11. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007; 293: E444-52;
12. PMID:17473055; http://dx.doi.org/10.1152/ajpendo.00691.2006
13. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360:1509-17;
14. PMID:19357406; http://dx.doi.org/10.1056/ NEJMoa0810780
15. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360:1518-25;
16. PMID:19357407; http://dx.doi.org/10.1056/ NEJMoa0808949
17. Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, et al. Beige adipocytes are a distinct type of thermo- genic fat cell in mouse and human. Cell 2012; 150:366-76;
18. PMID:22796012; http://dx.doi.org/ 10.1016/j.cell.2012.05.016
19. Jespersen NZ, Larsen TJ, Peijs L, Daugaard S, Homoe P, Loft A, de Jong J, Mathur N, Cannon B, Nedergaard J, et al. A classical brown adipose tissue mRNA signa- ture partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013; 17:798-805;
20. PMID:23663743; http://dx.doi.org/10.1016/j.cmet. 2013.04.011
21. Walden TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J. Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues. Am J Physiol Endocrinol Metab 2012; 302:E19-31;
22. PMID:21828341; http://dx.doi.org/10.1152/ajpendo. 00249.2011
23. Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev 2013; 27:234-50;
24. PMID:23388824; http://dx.doi.org/10.1101/gad.211649.112
25. Giralt M, Villarroya F. White, brown, beige/brite: different adipose cells for different functions? Endocrinology 2013; 154:2992-3000;
26. PMID:23782940; http:// dx.doi.org/10.1210/en.2013-1403
27. Contreras C, Gonzalez F, Fernø J, Dieguez C, Rahmouni K, Nogueiras R, Lopez M. The brain and brown fat. Ann Med 2014:1-19;
28. PMID:24915455; http://dx. doi.org/10.3109/07853890.2014.919727
29. Morrison SF, Madden CJ, Tupone D. Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab 2014; 19:741-56;
30. PMID:24630813; http://dx.doi.org/10.1016/j.cmet. 2014.02.007Adipocyte
31. Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 1987; 79:616-9;
32. PMID:3543057; http://dx.doi.org/10.1172/JCI112855
33. Calanna S, Christensen M, Holst JJ, Laferrere B, Gluud LL, Vilsboll T, Knop FK. Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: sys- tematic review and meta-analyses of clinical studies. Diabetologia 2013; 56:965-72;
34. PMID:23377698; http://dx.doi.org/10.1007/s00125-013-2841-0
35. Campbell JE, Drucker DJ. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab 2013; 17:819-37;
36. PMID:23684623; http://dx. doi.org/10.1016/j.cmet.2013.04.008
37. Goke R, Fehmann HC, Goke B. Glucagon-like peptide-1(7-36) amide is a new incretin/enterogastrone candidate. Eur J Clin Invest 1991; 21:135-44;
38. PMID:1647951; http://dx.doi.org/10.1111/j.1365- 2362.1991.tb01802.x
39. Gu G, Roland B, Tomaselli K, Dolman CS, Lowe C, Heilig JS. Glucagon-like peptide-1 in the rat brain: distribution of expression and functional implication. J Compar Neurol 2013; 521:2235-61;
40. PMID:23238833; http://dx. doi.org/10.1002/cne.23282
41. Richards P, Parker HE, Adriaenssens AE, Hodgson JM, Cork SC, Trapp S, Gribble FM, Reimann F. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes 2014; 63:1224-33;
42. PMID:24296712; http://dx.doi. org/10.2337/db13-1440
43. Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, et al. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes 2012; 61:2753-62;
44. PMID:22933116; http://dx.doi.org/10.2337/db11-1556
45. Beiroa D, Imbernon M, Gallego R, Senra A, Herranz D, Villarroya F, Serrano M, Fernø J, Salvador J, Escalada J, et al. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes 2014; 63:3346-58;
46. PMID:24917578; http://dx.doi.org/10.2337/db14-0302
47. Shimizu I, Hirota M, Ohboshi C, Shima K. Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology 1987; 121:1076-82
48. Bamshad M, Song CK, Bartness TJ. CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol 1999; 276:R1569-78;
49. PMID:10362733
50. Cano G, Passerin AM, Schiltz JC, Card JP, Morrison SF, Sved AF. Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tis- sue during cold exposure. J Compar Neurol 2003; 460:303-26;
51. PMID:12692852; http://dx.doi.org/10.1002/cne.10643
52. Morrison SF. RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue. Am J Physiol 1999; 276:R962-73;
53. PMID:10198373
54. Uno T, Shibata M. Role of inferior olive and thoracic IML neurons in nonshivering thermogenesis in rats. Am J Physiol Regul Integr Comp Physiol 2001; 280: R536-46;
55. PMID:11208585
56. Kim KW, Zhao L, Donato J Jr., Kohno D, Xu Y, Elias CF, Lee C, Parker KL, Elmquist JK. Steroidogenic factor 1 directs programs regulating diet-induced thermo- genesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A 2011; 108:10673-8;
57. PMID:21636788; http://dx.doi.org/10.1073/pnas.1102364108
58. Jo YH. Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus. J Neurophysiol 2012; 107:42-9;
59. PMID:21994261; http://dx.doi.org/10.1152/ jn.00353.2011
60. Lopez M, Varela L, Vazquez MJ, Rodriguez-Cuenca S, Gonzalez CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regu- lation of energy balance. Nat Med 2010; 16:1001-8;
61. PMID:20802499; http://dx.doi.org/10.1038/nm.2207
62. Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vazquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S, et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 2012; 149:871-85;
63. PMID:22579288; http://dx.doi.org/10.1016/j. cell.2012.02.066
64. Martinez de Morentin PB, Whittle AJ, Fernø J, Nogueiras R, Dieguez C, Vidal-Puig A, Lopez M. Nicotine induces negative energy balance through hypotha- lamic AMP-activated protein kinase. Diabetes 2012; 61:807-17;
65. PMID:22315316; http://dx.doi.org/10.2337/db11-1079
66. Tanida M, Yamamoto N, Shibamoto T, Rahmouni K. Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation. PloS one 2013; 8:e56660;
67. PMID:23418591; http://dx. doi.org/10.1371/journal.pone.0056660
68. Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, et al. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab 2010; 12:78-87;
69. PMID:20620997; http://dx.doi.org/10.1016/j. cmet.2010.05.010
70. Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, et al. O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell 2014;
71. 159:306-17;
72. PMID:25303527; http://dx. doi.org/10.1016/j.cell.2014.09.010
73. Marre M, Shaw J, Brandle M, Bebakar WM, Kamarud- din NA, Strand J, Zhang K, Yin R, Wu J, Horvath TL, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in sub- jects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009; 26:268-78;
74. PMID:19317822; http://dx.doi.org/10.1111/j.1464-5491.2009.02666.x
75. Astrup A, Rossner S, Van Gaal L, Rissanen A, Niskanen L, Al Hakim M, Madsen J, Rasmussen MF, Lean ME; NN8022-1807 Study Group. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009; 374:1606-16;
76. PMID:19853906; http://dx.doi.org/10.1016/S0140- 6736(09)61375-1
77. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B; American Diabetes Association; European Association for the Study of Dia- betes. Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initia- tion and adjustment of therapy: a consensus statement from the American Diabetes Association and the Euro- pean Association for the Study of Diabetes. Diabetolo- gia 2009; 52:17-30;
78. PMID:18941734; http://dx.doi. org/10.1007/s00125-008-1157-y
79. Torekov SS, Madsbad S, Holst JJ. Obesity-an indica- tion for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential. Obesity Rev 2011; 12:593-601;
80. PMID:21401851; http://dx.doi.org/10.1111/j.1467-789X.2011.00860.x
81. Sisley S, Gutierrez-Aguilar R, Scott M, D’Alessio DA, Sandoval DA, Seeley RJ. Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect. J Clin Invest 2014; 124:2456-63;
82. PMID:24762441; http://dx.doi.org/10.1172/JCI72434
83. Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, et al. A new glucagon and GLP-1 co- agonist eliminates obesity in rodents. Nat Chem Biol 2009; 5:749-57;
84. PMID:19597507; http://dx.doi.org/10.1038/nchembio.209
85. Finan B, Ma T, Ottaway N, Muller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, et al. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med 2013; 5:209ra151;
86. PMID:24174327; http://dx.doi.org/10.1126/scitranslmed.3007218