RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 276, Issue 4 45-4, 1999, Pages

  Morrison, Shaun F ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Bicuculline; Fever; Hypothermia; Sympathetic rhythms; Thermogenesis

Indexed keywords

BICUCULLINE; MUSCIMOL;

ADIPOCYTE; ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BROWN ADIPOSE TISSUE; CELL METABOLISM; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; THERMOGENESIS; THERMOREGULATION; VASOCONSTRICTION;

EID: 0032958372     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.276.4.r962     Document Type: Article

References (36)

1. Barman, S. M., and G. L. Gebber. Axonal projection patterns of ventrolateral medullospinal sympathoexcitatory neurons. J. Neurophysiol. 53: 1551-1566, 1985.
2. Barman, S. M., G. L. Gebber, and F. R. Calaresu. Differential control of sympathetic nerve discharge by the brain stem. Am. J. Physiol. 247 (Regulatory Integrative Comp. Physiol. 16): R513-R519, 1984.
3. Bendat, J. S., and A. G. Piersol. Random Data, Analysis and Measurement Procedures. New York: Wiley, 1986.
4. Brown, D. L., and P. G. Guyenet. Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats. Circ. Res. 56: 359-369, 1985.
5. Cannon, B., J. Nedergaard, J. M. Lundberg, T. Hokfelt, L. Terenius, and M. Goldstein. "Neuropeptide tyrosine" (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue. Exp. Cell Res. 164: 546-550, 1986.
6. Cannon, W. B. The Wisdom of the Body. New York: Norton, 1939.
7. Dean, C., J. L. Seagard, F. A. Hopp, and J. P. Kampine. Differential control of sympathetic activity to kidney and skeletal muscle by ventral medullary neurons. J. Auton. Nerv. Syst. 37: 1-10, 1992.
8. Gebber, G. L. Central determinants of sympathetic nerve discharge. In: Central Regulation of Autonomic Functions, edited by A. D. Loewy and K. M. Spyer. New York: Oxford University Press, 1990, p. 126-144.
9. Gebber, G. L., S. Zhong, and S. M. Barman. Synchronization of cardiac-related discharges of sympathetic nerves with inputs from widely separated spinal segments. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R1472-R1483, 1995.
10. Gebber, G. L., S. Zhong, S. M. Barman, and H. S. Orer. Coordination of the cardiac-related discharges of sympathetic nerves with different targets. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R400-R407, 1994.
11. Gebber, G. L., S. Zhong, S. M. Barman, Y. Paitel, and H. S. Orer. Differential relationships among the 10-Hz rhythmic discharges of sympathetic nerves with different targets. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R387-R399, 1994.
12. Guyenet, P. G. Role of the ventral medulla oblongata in blood pressure regulation. In: Central Regulation of Autonomic Functions, edited by A. D. Loewy and K. M. Spyer. New York: Oxford University Press, 1990, p. 145-167.
13. Haynes, W. G., D. A. Morgan, S. A. Walsh, A. L. Mark, and W. I. Sivitz. Receptor-mediated regional sympathetic nerve activation by leptin. J. Clin. Invest. 100: 270-278, 1997.
14. Hori, T. An update on thermosensitive neurons in the brain: from cellular biology to thermal and non-thermal homeostatic functions. Jpn. J. Physiol. 41: 1-22, 1991.
15. Janig, W., and E. M. McLachlan. Characteristics of function-specific pathways in the sympathetic nervous system. Trends Neurosci. 15: 475-481, 1992.
16. Johnson, C. D., and M. P. Gilbey. Sympathetic activity recorded from the rat caudal ventral artery in vivo. J. Physiol. (Lond.) 476: 437-442, 1994.
17. Kocsis, B. Baroreceptor influence on the relationships between discharges of different sympathetic nerves of the cat. J. Physiol. (Lond.) 482: 687-696, 1995.
18. Kocsis, B. Basis for differential coupling between rhythmic discharges of sympathetic efferent nerves. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R1008-R1019, 1994.
19. Kocsis, B., G. L. Gebber, S. M. Barman, and M. J. Kenney. Relationships between activity of sympathetic nerve pairs: phase and coherence. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R549-R560, 1990.
20. Koga, H., T. Hori, T. Kiyohara, and T. Nakashima. Responses of preoptic thermosensitive neurons to changes in blood pressure. Brain Res. Bull. 18: 749-755, 1987.
21. Lipski, J., R. Kanjhan, B. Kruszewska, and W. Rong. Properties of presympathetic neurones in the rostral ventrolateral medulla in the rat: an intracellular study "in vivo." J. Physiol. (Lond.) 490: 729-744, 1996.
22. Loewy, A. D. Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res. 222: 129-133, 1981.
23. Lovick, T. A. Differential control of cardiac and vasomotor activity by neurones in nucleus paragigantocellularis lateralis in the cat. J. Physiol. (Lond.) 389: 23-35, 1987.
24. McAllen, R. M. Identification and properties of sub-retrofacial bulbospinal neurones: a descending cardiovascular pathway in the cat. J. Auton. Nerv. Syst. 17: 151-164, 1985.
25. McAllen, R. M., and C. N. May. Differential drives from rostral ventrolateral medullary neurons to three identified sympathetic outflows. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R935-R944, 1994.
26. Morrison, S. F. Differential control of sympathetic outflow to brown adipose tissue and to the splanchnic bed by the raphe pallidus (RPa) and the rostral ventrolateral medulla (RVLM). Soc. Neurosci. Abstr. 23: 839, 1997.
27. Morrison, S. F. Raphe pallidus excites a unique class of sympathetic preganglionic neurons. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R82-R89, 1993.
28. Morrison, S. F., T. A. Milner, and D. J. Reis. Reticulospinal vasomotor neurons of the rat rostral ventrolateral medulla: relationship to sympathetic nerve activity and the C1 adrenergic cell group. J. Neurosci. 8: 1286-1301, 1988.
29. Morrison, S. F., A. F. Sved, and A. M. Passerin. GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R290-R297, 1999.
30. Nechad, M. Structure and development of brown adipose tissue. In: Brown Adipose Tissue, edited by P. Trayhurn and D. Nicholls. London: Edward Arnold, 1986, p. 1-30.
31. Nicholas, A. P., and M. B. Hancock. Projections from the rostral ventrolateral medulla to brainstem monoamine neurons in the rat. Neurosci. Lett. 122: 91-95, 1991.
32. Paxinos, G., and C. Watson. The Rat Brain in Stereotaxic Coordinates. Sydney, Australia: Academic, 1986.
33. Rathner, J. A., D. Trevaks, and R. M. McAllen. Which medullary neuron groups drive the vasomotor supply to the rat's tail? Soc. Neurosci. Abstr. 24: 627, 1998.
34. Smith, J. E., A. S. Jansen, M. P. Gilbey, and A. D. Loewy. CNS cell groups projecting to sympathetic outflow of tail artery: neural circuits involved in heat loss in the rat. Brain Res. 786: 153-164, 1998.
35. Smith, R. E., and B. A. Horwitz. Brown fat and thermogenesis. Physiol. Rev. 49: 330-425, 1969.
36. Strack, A. M., W. B. Sawyer, J. H. Hughes, K. B. Platt, and A. D. Loewy. A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infections. Brain Res. 491: 156-162, 1989.