Yos9p detects and targets misfolded glycoproteins for ER-associated degradation

Molecular Cell

Volumn 19, Issue 6, 2005, Pages 753-764

  Kim, Woong ^a,b   Spear, Eric D ^a,c   Ng, Davis T W ^a,d  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCAN; GLYCOPROTEIN; LECTIN RECEPTOR; MEMBRANE PROTEIN; PROTEIN; PROTEIN HTM1; UNCLASSIFIED DRUG; YEAST OSTEOSARCOMA 9 PROTEIN;

ARTICLE; CYTOSOL; ENDOPLASMIC RETICULUM; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN TARGETING; QUALITY CONTROL; SIGNAL TRANSDUCTION;

CARBOXYPEPTIDASES; CARRIER PROTEINS; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; PROTEIN CONFORMATION; PROTEIN FOLDING; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 24944552879     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.08.010     Document Type: Article

References (47)

1. A. Ahner, and J.L. Brodsky Checkpoints in ER-associated degradation: excuse me, which way to the proteasome? Trends Cell Biol. 14 2004 474 478
2. J.D. Bendtsen, H. Nielsen, G. von Heijne, and S. Brunak Improved prediction of signal peptides: SignalP 3.0 J. Mol. Biol. 340 2004 783 795
3. A. Bhamidipati, V. Denic, E.M. Quan, and J.S. Weissman Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen this issue Mol. Cell 19 2005 741 751
4. B.A. Buschhorn, Z. Kostova, B. Medicherla, and D.H. Wolf A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins FEBS Lett. 577 2004 422 426
5. L. Ellgaard, and A. Helenius Quality control in the endoplasmic reticulum Nat. Rev. Mol. Cell Biol. 4 2003 181 191
6. E. Friedmann, Y. Salzberg, A. Weinberger, S. Shaltiel, and J.E. Gerst YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins J. Biol. Chem. 277 2002 35274 35281
7. T.R. Gemmill, and R.B. Trimble Overview of N- and O-linked oligosaccharide structures found in various yeast species Biochim. Biophys. Acta 1426 1999 227 237
8. N. Hosokawa, I. Wada, K. Hasegawa, T. Yorihuzi, L.O. Tremblay, A. Herscovics, and K. Nagata A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation EMBO Rep. 2 2001 415 422
9. G. Huyer, W.F. Piluek, Z. Fansler, S.G. Kreft, M. Hochstrasser, J.L. Brodsky, and S. Michaelis Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble lumenal protein J. Biol. Chem. 279 2004 38369 38378
10. C.A. Jakob, P. Burda, J. Roth, and M. Aebi Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure J. Cell Biol. 142 1998 1223 1233
11. C.A. Jakob, P. Burda, J. Roth, and M. Aebi Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure J. Cell Biol. 142 1998 1223 1233
12. C.A. Jakob, D. Bodmer, U. Spirig, P. Battig, A. Marcil, D. Dignard, J.J. Bergeron, D.Y. Thomas, and M. Aebi Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast EMBO Rep. 2 2001 423 430
13. E. Jarosch, C. Taxis, C. Volkwein, J. Bordallo, D. Finley, D.H. Wolf, and T. Sommer Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48 Nat. Cell Biol. 4 2002 134 139
14. A.E. Johnson, and M.A. van Waes The translocon: a dynamic gateway at the ER membrane Annu. Rev. Cell Dev. Biol. 15 1999 799 842
15. M. Knop, A. Finger, T. Braun, K. Hellmuth, and D.H. Wolf Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast EMBO J. 15 1996 753 763
16. M. Knop, N. Hauser, and D.H. Wolf N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast Yeast 12 1996 1229 1238
17. Z. Kostova, and D.H. Wolf For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection EMBO J. 22 2003 2309 2317
18. Z. Kostova, and D.H. Wolf Importance of carbohydrate positioning in the recognition of mutated CPY for ER-associated degradation J. Cell Sci. 118 2005 1485 1492
19. R.J. Lee, C.W. Liu, C. Harty, A.A. McCracken, M. Latterich, K. Romisch, G.N. DeMartino, P.J. Thomas, and J.L. Brodsky Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein EMBO J. 23 2004 2206 2215
20. B.N. Lilley, and H.L. Ploegh A membrane protein required for dislocation of misfolded proteins from the ER Nature 429 2004 834 840
21. Y. Liu, P. Choudhury, C.M. Cabral, and R.N. Sifers Intracellular disposal of incompletely folded alpha1-antitrypsin involves release from calnexin and post-translational folding of asparagine-linked oligosaccharides J. Biol. Chem. 272 1997 7946 7951
22. D. Loayza, A. Tam, W.K. Schmidt, and S. Michaelis Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae Mol. Biol. Cell 9 1998 2767 2784
23. A.A. McCracken, and J.L. Brodsky Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD) Bioessays 25 2003 868 877
24. S.L. Meacock, J.J. Greenfield, and S. High Protein targeting and translocation at the endoplasmic reticulum membrane-through the eye of a needle? Essays Biochem. 36 2000 1 13
25. M. Molinari, C. Galli, V. Piccaluga, M. Pieren, and P. Paganetti Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER J. Cell Biol. 158 2002 247 257
26. M. Molinari, V. Calanca, C. Galli, P. Lucca, and P. Paganetti Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle Science 299 2003 1397 1400
27. S. Munro The MRH domain suggests a shared ancestry for the mannose 6-phosphate receptors and other N-glycan-recognising proteins Curr. Biol. 11 2001 R499 R501
28. K. Nakatsukasa, S. Nishikawa, N. Hosokawa, K. Nagata, and T. Endo Mnl1p, an alpha-mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins J. Biol. Chem. 276 2001 8635 8638
29. D.T. Ng, E.D. Spear, and P. Walter The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control J. Cell Biol. 150 2000 77 88
30. S. Nishikawa, S.W. Fewell, Y. Kato, J.L. Brodsky, and T. Endo Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation J. Cell Biol. 153 2001 1 10
31. C. Nuoffer, P. Jeno, A. Conzelmann, and H. Riezman Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membrane Mol. Cell. Biol. 11 1991 27 37
32. M. Pilon, R. Schekman, and K. Romisch Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation EMBO J. 16 1997 4540 4548
33. R.K. Plemper, S. Bohmler, J. Bordallo, T. Sommer, and D.H. Wolf Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation Nature 388 1997 891 895
34. K. Romisch Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane J. Cell Sci. 112 1999 4185 4191
35. U. Schubert, L.C. Anton, J. Gibbs, C.C. Norbury, J.W. Yewdell, and J.R. Bennink Rapid degradation of a large fraction of newly synthesized proteins by proteasomes Nature 404 2000 770 774
36. R. Sitia, and I. Braakman Quality control in the endoplasmic reticulum protein factory Nature 426 2003 891 894
37. E.D. Spear, and D.T.W. Ng Stress tolerance of misfolded carboxypeptidase y requires maintenance of protein trafficking and degradative pathways Mol. Biol. Cell 14 2003 2756 2767
38. Spear, E.D., and Ng, D.T.W. (2005). Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation. J. Cell Biol. 169, in press. Published online April 4, 2005. 10.1083/jcb.200411136.
39. R. Szathamary, R. Bielmann, M. Nita-Lazar, P. Burda, and C.A. Jakob Yos9 protein is essential for degradation of misfolded glycoproteins and may function as a lectin in ERAD this issue Mol. Cell 19 2005 765 775
40. F. Tokunaga, C. Brostrom, T. Koide, and P. Arvan Endoplasmic reticulum (ER)-associated degradation of misfolded N-linked glycoproteins is suppressed upon inhibition of ER mannosidase I J. Biol. Chem. 275 2000 40757 40764
41. E.S. Trombetta, and A.J. Parodi Quality control and protein folding in the secretory pathway Annu. Rev. Cell Dev. Biol. 19 2003 649 676
42. S. Vashist, and D.T. Ng Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control J. Cell Biol. 165 2004 41 52
43. S. Vashist, W. Kim, W.J. Belden, E.D. Spear, C. Barlowe, and D.T. Ng Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding J. Cell Biol. 155 2001 355 368
44. Y. Ye, H.H. Meyer, and T.A. Rapoport The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol Nature 414 2001 652 656
45. Y. Ye, H.H. Meyer, and T.A. Rapoport Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains J. Cell Biol. 162 2003 71 84
46. Y. Ye, Y. Shibata, C. Yun, D. Ron, and T.A. Rapoport A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol Nature 429 2004 841 847
47. M. Zhou, and R. Schekman The engagement of Sec61p in the ER dislocation process Mol. Cell 4 1999 925 934