Polymerase ζ activity is linked to Replication timing in humans: Evidence from mutational signatures

Molecular Biology and Evolution

Volumn 32, Issue 12, 2015, Pages 3158-3172

  Seplyarskiy, Vladimir B ^a,b,c   Bazykin, Georgii A ^a,b,c   Soldatov, Ruslan A ^a,b  

^a INSTITUTE FOR INFORMATION TRANSMISSION PROBLEMS   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

Amyotrophic lateral sclerosis; HRAS; Mutation rate; Polymerase zeta; Replication timing; Transcription

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DNA POLYMERASE; DNA POLYMERASE ZETA; H RAS PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; DNA DIRECTED DNA POLYMERASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BOOTSTRAPPING; CHIMPANZEE; COSTELLO SYNDROME; DINUCLEOTIDE MUTATION; DNA BASE COMPOSITION; DNA REPLICATION TIMING; ENZYME ACTIVITY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; MUTATION RATE; NONHUMAN; ORANGUTAN; PRIMATE; ANIMAL; DINUCLEOTIDE REPEAT; DNA REPLICATION; DNA SEQUENCE; GENETICS; GERMLINE MUTATION; HUMAN; HUMAN GENOME; METABOLISM; PHYSIOLOGY; POINT MUTATION; PROTEIN TERTIARY STRUCTURE;

ANIMALS; DINUCLEOTIDE REPEATS; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; GENOME, HUMAN; GERM-LINE MUTATION; HUMANS; POINT MUTATION; PRIMATES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, DNA;

EID: 84948692272     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msv184     Document Type: Article

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