Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 50, 2013, Pages 20152-20157

  Giannoulatou, Eleni ^a   McVean, Gilean ^b   Taylor, Indira B ^a   McGowan, Simon J ^a   Maher, Geoffrey J ^a   Iqbal, Zamin ^b   Pfeifer, Susanne P ^b,g   Turner, Isaac ^b   Burkitt Wright, Emma M M ^c   Shorto, Jennifer ^c   Itani, Aysha ^d   Turner, Karen ^d   Gregory, Lorna ^b   Buck, David ^b   Rajpert De Meyts, Ewa ^e   Looijenga, Leendert H J ^f   Kerr, Bronwyn ^c   Wilkie, Andrew O M ^a   Goriely, Anne ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d Institute of Reproductive Sciences   (United Kingdom)

^e University of Copenhagen   (Denmark)

^f ERASMUS MEDICAL CENTER   (Netherlands)

^g MAX F PERUTZ LABORATORIES   (Austria)

Author keywords

Male mutation bias; Paternal age effect; RASopathy; Testis

Indexed keywords

ADULT; AGED; ARTICLE; CARCINOGENESIS; CODON; CONTROLLED STUDY; COSTELLO SYNDROME; GENETIC ANALYSIS; GERM CELL; HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG; HARVEY SARCOMA ONCOVIRUS; HUMAN; IN VITRO STUDY; MALE; MUTATION RATE; NORMAL HUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SELFISH SPERMATOGONIAL SELECTION; SPERM; SPERMATOGONIUM; VIRUS MUTATION;

EID: 84890285897     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1311381110     Document Type: Article

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