메뉴 건너뛰기




Volumn 49, Issue 2, 2015, Pages 301-316

Circadian disruption reveals a correlation of an oxidative GSH/GSSG Redox shift with learning and impaired memory in an Alzheimer's disease mouse model

Author keywords

Alzheimer's disease; APPSwDI NOS2 ; circadian disruption; glutathione; GSH; jet lag; learning; memory; redox; sleep

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; AMYLOID PRECURSOR PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NOS2 PROTEIN, MOUSE;

EID: 84948691445     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150026     Document Type: Article
Times cited : (13)

References (64)
  • 1
    • 77953886784 scopus 로고    scopus 로고
    • Current status on Alzheimer disease molecular genetics: From past, to present, to future
    • Bettens K, Slegers K, Van Broeckhoven C (2010) Current status on Alzheimer disease molecular genetics: From past, to present, to future. Hum Mol Genet 19, R4-R11.
    • (2010) Hum Mol Genet , vol.19 , pp. R4-R11
    • Bettens, K.1    Slegers, K.2    Van Broeckhoven, C.3
  • 2
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: Prevalence estimates using the 2000 census
    • Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: Prevalence estimates using the 2000 census. Arch Neurol 60, 1119-1122.
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 4
    • 84879781233 scopus 로고    scopus 로고
    • Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
    • Intlekofer KA, Cotman CW (2013) Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis 57, 47-55.
    • (2013) Neurobiol Dis , vol.57 , pp. 47-55
    • Intlekofer, K.A.1    Cotman, C.W.2
  • 5
    • 0034656008 scopus 로고    scopus 로고
    • Influence of social network on occurrence of dementia: A community-based longitudinal study
    • Fratiglioni L, Wang HX, Ericsson K, Maytan M, Winblad B (2000) Influence of social network on occurrence of dementia: A community-based longitudinal study. Lancet 355, 1315-1319.
    • (2000) Lancet , vol.355 , pp. 1315-1319
    • Fratiglioni, L.1    Wang, H.X.2    Ericsson, K.3    Maytan, M.4    Winblad, B.5
  • 8
    • 84863574143 scopus 로고    scopus 로고
    • Pro: Alzheimer's disease and circadian dysfunction: Chicken or egg?
    • Bedrosian TA, Nelson RJ (2012) Pro: Alzheimer's disease and circadian dysfunction: Chicken or egg? Alzheimers Res Ther 4, 25.
    • (2012) Alzheimers Res Ther , vol.4 , pp. 25
    • Bedrosian, T.A.1    Nelson, R.J.2
  • 10
    • 0036372619 scopus 로고    scopus 로고
    • Redox potential of GSH/GSSG couple: Assay and biological significance
    • Jones DP (2002) Redox potential of GSH/GSSG couple: Assay and biological significance. Meth Enzymol 348, 93-112.
    • (2002) Meth Enzymol , vol.348 , pp. 93-112
    • Jones, D.P.1
  • 12
    • 84905008400 scopus 로고    scopus 로고
    • Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons
    • Ghosh D, Levault KR, Brewer GJ (2014) Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell 13, 631-640.
    • (2014) Aging Cell , vol.13 , pp. 631-640
    • Ghosh, D.1    Levault, K.R.2    Brewer, G.J.3
  • 13
    • 76749126321 scopus 로고    scopus 로고
    • Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories
    • Brewer GJ (2010) Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp Gerontol 45, 173-179.
    • (2010) Exp Gerontol , vol.45 , pp. 173-179
    • Brewer, G.J.1
  • 15
    • 78649725166 scopus 로고    scopus 로고
    • Mammalian circadian clock and metabolism-Dhe epigenetic link
    • Bellet MM, Sassone-Corsi P (2010) Mammalian circadian clock and metabolism-Dhe epigenetic link. J Cell Sci 123, 3837-3848.
    • (2010) J Cell Sci , vol.123 , pp. 3837-3848
    • Bellet, M.M.1    Sassone-Corsi, P.2
  • 17
    • 77953290430 scopus 로고    scopus 로고
    • Clocks in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging
    • Imai S (2010) "Clocks in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta 1804, 1584-1590.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1584-1590
    • Imai, S.1
  • 18
    • 39549115445 scopus 로고    scopus 로고
    • Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2
    • Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA (2008) Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28, 1537-1545.
    • (2008) J Neurosci , vol.28 , pp. 1537-1545
    • Wilcock, D.M.1    Lewis, M.R.2    Van Nostrand, W.E.3    Davis, J.4    Previti, M.L.5    Gharkholonarehe, N.6    Vitek, M.P.7    Colton, C.A.8
  • 19
    • 84860170321 scopus 로고    scopus 로고
    • A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons
    • Ghosh D, Levault KR, Barnett AJ, Brewer GJ (2012) A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J Neurosci 32, 5821-5832.
    • (2012) J Neurosci , vol.32 , pp. 5821-5832
    • Ghosh, D.1    Levault, K.R.2    Barnett, A.J.3    Brewer, G.J.4
  • 20
    • 84885181278 scopus 로고    scopus 로고
    • Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species
    • Ghosh D, LeVault KR, Brewer GJ (2014) Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species. Neurobiol Aging 35, 179-190.
    • (2014) Neurobiol Aging , vol.35 , pp. 179-190
    • Ghosh, D.1    LeVault, K.R.2    Brewer, G.J.3
  • 21
    • 0000519682 scopus 로고
    • Reduction-potential of glutathione
    • Rost J, Rapoport S (1964) Reduction-potential of glutathione. Nature 201, 185.
    • (1964) Nature , vol.201 , pp. 185
    • Rost, J.1    Rapoport, S.2
  • 22
    • 0034888287 scopus 로고    scopus 로고
    • Applications of the Morris water maze in the study of learning and memory
    • D'Hooge R, De Deyn PP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Brain Res Rev 36, 60-90.
    • (2001) Brain Res Brain Res Rev , vol.36 , pp. 60-90
    • D'Hooge, R.1    De Deyn, P.P.2
  • 24
    • 58549098713 scopus 로고    scopus 로고
    • Glutathione depletion in the brain disrupts short-Derm spatial memory in the Y-maze in rats and mice
    • Dean O, Bush AI, Berk M, Copolov DL, van den Buuse M (2009) Glutathione depletion in the brain disrupts short-Derm spatial memory in the Y-maze in rats and mice. Behav Brain Res 198, 258-262.
    • (2009) Behav Brain Res , vol.198 , pp. 258-262
    • Dean, O.1    Bush, A.I.2    Berk, M.3    Copolov, D.L.4    Van Den Buuse, M.5
  • 25
    • 84863567161 scopus 로고    scopus 로고
    • Con: Alzheimer's disease and circadian dysfunction: Chicken or egg?
    • Moghekar A, O'Brien RJ (2012) Con: Alzheimer's disease and circadian dysfunction: Chicken or egg? Alzheimers Res Ther 4, 26.
    • (2012) Alzheimers Res Ther , vol.4 , pp. 26
    • Moghekar, A.1    O'Brien, R.J.2
  • 26
    • 2342444955 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease with stabilized oral nicotinamide adenine dinucleotide: A randomized, double-blind study
    • Demarin V, Podobnik SS, Storga-Domic D, Kay G (2004) Treatment of Alzheimer's disease with stabilized oral nicotinamide adenine dinucleotide: A randomized, double-blind study. Drugs Exp Clin Res 30, 27-33.
    • (2004) Drugs Exp Clin Res , vol.30 , pp. 27-33
    • Demarin, V.1    Podobnik, S.S.2    Storga-Domic, D.3    Kay, G.4
  • 27
    • 0035940625 scopus 로고    scopus 로고
    • Controlled trial of Nacetylcysteine for patients with probable Alzheimer's disease
    • Adair JC, Knoefel JE, Morgan N (2001) Controlled trial of Nacetylcysteine for patients with probable Alzheimer's disease. Neurology 57, 1515-1517.
    • (2001) Neurology , vol.57 , pp. 1515-1517
    • Adair, J.C.1    Knoefel, J.E.2    Morgan, N.3
  • 28
    • 84875381499 scopus 로고    scopus 로고
    • Sundowning syndrome in aging and dementia: Research in mouse models
    • Bedrosian TA, Nelson RJ (2013) Sundowning syndrome in aging and dementia: Research in mouse models. Exp Neurol 243, 67-73.
    • (2013) Exp Neurol , vol.243 , pp. 67-73
    • Bedrosian, T.A.1    Nelson, R.J.2
  • 30
    • 77954887739 scopus 로고    scopus 로고
    • Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
    • Wulff K, Gatti S, Wettstein JG, Foster RG (2010) Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci 11, 589-599.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 589-599
    • Wulff, K.1    Gatti, S.2    Wettstein, J.G.3    Foster, R.G.4
  • 31
    • 37149023803 scopus 로고    scopus 로고
    • Sleep disturbances in spousal caregivers of individuals with Alzheimer's disease
    • Creese J, Bedard M, Brazil K, Chambers L (2008) Sleep disturbances in spousal caregivers of individuals with Alzheimer's disease. Int Psychogeriatr 20, 149-161.
    • (2008) Int Psychogeriatr , vol.20 , pp. 149-161
    • Creese, J.1    Bedard, M.2    Brazil, K.3    Chambers, L.4
  • 32
    • 84867337764 scopus 로고    scopus 로고
    • Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: An actigraphic study
    • Cochrane A, Robertson IH, Coogan AN (2012) Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: An actigraphic study. J Neural Transm 119, 1233-1239.
    • (2012) J Neural Transm , vol.119 , pp. 1233-1239
    • Cochrane, A.1    Robertson, I.H.2    Coogan, A.N.3
  • 35
    • 0029121750 scopus 로고
    • VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease
    • Zhou JN, Hofman MA, Swaab DF (1995) VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease. Neurobiol Aging 16, 571-576.
    • (1995) Neurobiol Aging , vol.16 , pp. 571-576
    • Zhou, J.N.1    Hofman, M.A.2    Swaab, D.F.3
  • 38
    • 79953281764 scopus 로고    scopus 로고
    • Circadian clock gene expression in brain regions of Alzheimer's disease patients and control subjects
    • Cermakian N, Lamont EW, Boudreau P, Boivin DB (2011) Circadian clock gene expression in brain regions of Alzheimer's disease patients and control subjects. J Biol Rhythms 26, 160-170.
    • (2011) J Biol Rhythms , vol.26 , pp. 160-170
    • Cermakian, N.1    Lamont, E.W.2    Boudreau, P.3    Boivin, D.B.4
  • 40
    • 77955714612 scopus 로고    scopus 로고
    • Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1 Circadian changes
    • Sterniczuk R, Dyck RH, Laferla FM, Antle MC (2010) Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes. Brain Res 1348, 139-148.
    • (2010) Brain Res , vol.1348 , pp. 139-148
    • Sterniczuk, R.1    Dyck, R.H.2    Laferla, F.M.3    Antle, M.C.4
  • 41
    • 0018933609 scopus 로고
    • Selective effects of kainic acid on diencephalic neurons
    • Peterson GM, Moore RY (1980) Selective effects of kainic acid on diencephalic neurons. Brain Res 202, 165-182.
    • (1980) Brain Res , vol.202 , pp. 165-182
    • Peterson, G.M.1    Moore, R.Y.2
  • 42
    • 0030591470 scopus 로고    scopus 로고
    • Glutamate receptor-induced toxicity in neostriatal cells
    • Colwell CS, Levine MS (1996) Glutamate receptor-induced toxicity in neostriatal cells. Brain Res 724, 205-212.
    • (1996) Brain Res , vol.724 , pp. 205-212
    • Colwell, C.S.1    Levine, M.S.2
  • 43
  • 44
    • 80051725947 scopus 로고    scopus 로고
    • ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells
    • Karmarkar SW, Bottum KM, Krager SL, Tischkau SA (2011) ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells. PLoS One 6, e23493.
    • (2011) PLoS One , vol.6 , pp. e23493
    • Karmarkar, S.W.1    Bottum, K.M.2    Krager, S.L.3    Tischkau, S.A.4
  • 47
    • 77958535241 scopus 로고    scopus 로고
    • Rapid changes in the light/dark cycle disrupt memory of conditioned fear in mice
    • Loh DH, Navarro J, Hagopian A, Wang LM, Deboer T, Colwell CS (2010) Rapid changes in the light/dark cycle disrupt memory of conditioned fear in mice. PLoS One 5, 1-12.
    • (2010) PLoS One , vol.5 , pp. 1-12
    • Loh, D.H.1    Navarro, J.2    Hagopian, A.3    Wang, L.M.4    Deboer, T.5    Colwell, C.S.6
  • 50
    • 84880571172 scopus 로고    scopus 로고
    • Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease
    • Walker MP, LaFerla FM, Oddo SS, Brewer GJ (2013) Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr) 35, 519-531.
    • (2013) Age (Dordr) , vol.35 , pp. 519-531
    • Walker, M.P.1    LaFerla, F.M.2    Oddo, S.S.3    Brewer, G.J.4
  • 51
    • 0038664183 scopus 로고    scopus 로고
    • Coupling of neuronal activity and mitochondrial metabolism as revealed by NAD(P)H fluorescence signals in organotypic hippocampal slice cultures of the rat
    • Kann O, Schuchmann S, Buchheim K, Heinemann U (2003) Coupling of neuronal activity and mitochondrial metabolism as revealed by NAD(P)H fluorescence signals in organotypic hippocampal slice cultures of the rat. Neuroscience 119, 87-100.
    • (2003) Neuroscience , vol.119 , pp. 87-100
    • Kann, O.1    Schuchmann, S.2    Buchheim, K.3    Heinemann, U.4
  • 52
    • 77249141031 scopus 로고    scopus 로고
    • Redox dysregulation affects the ventral but not dorsal hippocampus: Impairment of parvalbumin neurons, gamma oscillations, and related behaviors
    • Steullet P, Cabungcal JH, Kulak A, Kraftsik R, Chen Y, Dalton TP, Cuenod M, Do KQ (2010) Redox dysregulation affects the ventral but not dorsal hippocampus: Impairment of parvalbumin neurons, gamma oscillations, and related behaviors. J Neurosci 30, 2547-2558.
    • (2010) J Neurosci , vol.30 , pp. 2547-2558
    • Steullet, P.1    Cabungcal, J.H.2    Kulak, A.3    Kraftsik, R.4    Chen, Y.5    Dalton, T.P.6    Cuenod, M.7    Do, K.Q.8
  • 53
    • 30144435733 scopus 로고    scopus 로고
    • Synaptic plasticity impairment and hypofunction of induced by glutathione deficit: Relevance to schizophrenia
    • Steullet P, Neijt HC, Cuenod M, DoKQ(2006) Synaptic plasticity impairment and hypofunction of induced by glutathione deficit: Relevance to schizophrenia. Neuroscience 137, 807-819.
    • (2006) Neuroscience , vol.137 , pp. 807-819
    • Steullet, P.1    Neijt, H.C.2    Cuenod, M.3    Do, K.Q.4
  • 54
    • 84861039574 scopus 로고    scopus 로고
    • N-Acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development
    • das Neves Duarte JM, Kulak A, Gholam-Razaee MM, Cuenod M, Gruetter R, Do KQ (2012) N-Acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development. Biol Psychiatry 71, 1006-1014.
    • (2012) Biol Psychiatry , vol.71 , pp. 1006-1014
    • Das Neves Duarte, J.M.1    Kulak, A.2    Gholam-Razaee, M.M.3    Cuenod, M.4    Gruetter, R.5    Do, K.Q.6
  • 55
    • 76149095657 scopus 로고    scopus 로고
    • Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II
    • Bodhinathan K, Kumar A, Foster TC (2010) Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II. J Neurosci 30, 1914-1924.
    • (2010) J Neurosci , vol.30 , pp. 1914-1924
    • Bodhinathan, K.1    Kumar, A.2    Foster, T.C.3
  • 56
    • 78349251352 scopus 로고    scopus 로고
    • Reversal of aging-Associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function
    • Yang YJ, Wu PF, Long LH, Yu DF, WuWN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F, Chen JG (2010) Reversal of aging-Associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. Aging Cell 9, 709-721.
    • (2010) Aging Cell , vol.9 , pp. 709-721
    • Yang, Y.J.1    Wu, P.F.2    Long, L.H.3    Yu, D.F.4    Wuwn Hu, Z.L.5    Fu, H.6    Xie, N.7    Jin, Y.8    Ni, L.9    Wang, J.Z.10    Wang, F.11    Chen, J.G.12
  • 57
    • 79957795797 scopus 로고    scopus 로고
    • Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult
    • Robillard JM, Gordon GR, Choi HB, Christie BR, MacVicar BA (2011) Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult. PloS One 6, e20676.
    • (2011) PloS One , vol.6 , pp. e20676
    • Robillard, J.M.1    Gordon, G.R.2    Choi, H.B.3    Christie, B.R.4    MacVicar, B.A.5
  • 58
    • 84884924804 scopus 로고    scopus 로고
    • Linking redox regulation of NMDAR synaptic function to cognitive decline during aging
    • Kumar A, Foster TC (2013) Linking redox regulation of NMDAR synaptic function to cognitive decline during aging. J Neurosci 33, 15710-15715.
    • (2013) J Neurosci , vol.33 , pp. 15710-15715
    • Kumar, A.1    Foster, T.C.2
  • 59
    • 84872333110 scopus 로고    scopus 로고
    • Persistent impairments in hippocampal, dorsal striatal, and prefrontal cortical function following repeated photoperiod shifts in rats
    • Zelinski EL, Tyndall AV, Hong NS, McDonald RJ (2013) Persistent impairments in hippocampal, dorsal striatal, and prefrontal cortical function following repeated photoperiod shifts in rats. Exp Brain Res 224, 125-139.
    • (2013) Exp Brain Res , vol.224 , pp. 125-139
    • Zelinski, E.L.1    Tyndall, A.V.2    Hong, N.S.3    McDonald, R.J.4
  • 60
    • 79957795797 scopus 로고    scopus 로고
    • Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult
    • Robillard JM, Gordon GR, Choi HB, Christie BR, MacVicar BA (2011) Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult. PLoS One 6, e20676.
    • (2011) PLoS One , vol.6 , pp. e20676
    • Robillard, J.M.1    Gordon, G.R.2    Choi, H.B.3    Christie, B.R.4    MacVicar, B.A.5
  • 61
    • 84919935411 scopus 로고    scopus 로고
    • Effects of alpha-lipoic acid on spatial learning and memory, oxidative stress, and central cholinergic system in a rat model of vascular dementia
    • Zhao RR, Xu F, Xu XC, Tan GJ, Liu LM, Wu N, Zhang WZ, Liu JX (2015) Effects of alpha-lipoic acid on spatial learning and memory, oxidative stress, and central cholinergic system in a rat model of vascular dementia. Neurosci Lett 587, 113-119.
    • (2015) Neurosci Lett , vol.587 , pp. 113-119
    • Zhao, R.R.1    Xu, F.2    Xu, X.C.3    Tan, G.J.4    Liu, L.M.5    Wu, N.6    Zhang, W.Z.7    Liu, J.X.8
  • 62
    • 84882580016 scopus 로고    scopus 로고
    • Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Abeta and pTau in a mouse model of Alzheimer's disease
    • Rothman SM, Herdener N, Frankola KA, Mughal MR, Mattson MP (2013) Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Abeta and pTau in a mouse model of Alzheimer's disease. Brain Res 1529, 200-208.
    • (2013) Brain Res , vol.1529 , pp. 200-208
    • Rothman, S.M.1    Herdener, N.2    Frankola, K.A.3    Mughal, M.R.4    Mattson, M.P.5
  • 64
    • 0035919479 scopus 로고    scopus 로고
    • Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
    • Rutter J, Reick M, Wu LC, McKnight SL (2001) Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293, 510-514.
    • (2001) Science , vol.293 , pp. 510-514
    • Rutter, J.1    Reick, M.2    Wu, L.C.3    McKnight, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.