Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons

Aging Cell

Volumn 13, Issue 4, 2014, Pages 631-640

  Ghosh, Debolina ^a   Levault, Kelsey R ^a   Brewer, Gregory J ^a,b  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of California at Irvine   (United States)

Author keywords

3xTg AD; Aging; Glutathione; NAD(P)H; Neurodegeneration; Redox

Indexed keywords

GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; BUFFER; CYTOKINE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, MOUSE;

ADULT; AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; AUTOFLUORESCENCE; BRAIN; BRAIN HOMOGENATE; BRAIN TISSUE; CELL DEATH; DERIVATIZATION; ENDOTHELIUM CELL; ENZYME BLOOD LEVEL; ENZYME METABOLISM; ENZYME SYNTHESIS; FLUORESCENCE; GENE EXPRESSION; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MALE; MOUSE; NERVE CELL; NERVE CELL CULTURE; NERVE DEGENERATION; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; WHOLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TRANSGENIC MOUSE;

MUS;

AGING; ALZHEIMER DISEASE; ANIMALS; BUFFERS; CELL DEATH; CYTOKINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; MICE; MICE, TRANSGENIC; NADP; NADP TRANSHYDROGENASES; NERVE DEGENERATION; NEURONS; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OXIDATION-REDUCTION;

EID: 84905008400     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12216     Document Type: Article

References (46)

1. Ansari MA, Scheff SW (2010) Oxidative stress in the progression of Alzheimer disease in the frontal cortex. J. Neuropath. Exp. Neurol. 69, 155-167.
2. Brewer GJ (2010) Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp. Gerontol. 45, 173-179.
3. Brewer GJ, Torricelli JR (2007) Isolation and culture of adult neurons and neurospheres. Nat. Protoc. 2, 1490-1498.
4. Brewer GJ, Torricelli JR, Lindsey AL, Kunz EZ, Neuman A, Fisher DR, Joseph JA (2010) Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J. Nutr. Biochem. 21, 991-998.
5. Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE (2005) Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann. Neurol. 57, 695-703.
6. Chance B, Schoener B, Oshino R, Itshak F, Nakase Y (1979) Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals. J. Biol. Chem. 254, 4764-4771.
7. Chernyak BV, Bernardi P (1996) The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites. Eur. J. Biochem. 238, 623-630.
8. Diaz-Hernandez JI, Moncada S, Bolanos JP, Almeida A (2007) Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress. Cell Death Differ. 14, 1211-1221.
9. Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE (1996) Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J. Neurochem. 67, 1259-1267.
10. Eng J, Lynch RM, Balaban RS (1989) Nicotinamide adenine dinucleotide fluorescence spectroscopy and imaging of isolated cardiac myocytes. Biophys. J. 55, 621-630.
11. Fjeld CC, Birdsong WT, Goodman RH (2003) Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc. Natl Acad. Sci. USA 100, 9202-9207.
12. Freeman HC, Hugill A, Dear NT, Ashcroft FM, Cox RD (2006) Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes 55, 2153-2156.
13. Garcia J, Han D, Sancheti H, Yap LP, Kaplowitz N, Cadenas E (2010) Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J. Biol. Chem. 285, 39646-39654.
14. Ghosh D, LeVault KR, Barnett AJ, Brewer GJ (2012) A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J. Neurosci. 32, 5821-5832.
15. Ghosh D, Levault KR, Brewer GJ (2014) Dual energy precursor and Nrf2 activator treatment additively improve redox glutathione levels and neuron survival in aging and in Alzheimer mouse neurons upstream of ROS. Neurobiol. Aging 35, 179-190.
16. Guarente L (2011) Sirtuins, aging, and metabolism. Cold Spr. Harb. Symp. Quant. Biol. 76, 81-90.
17. Hulbert PB, Yakubu SI (1983) Monobromobimane: a substrate for the fluorimetric assay of glutathione transferase. J. Pharm. Pharmacol. 35, 384-386.
18. Icen A (1967) Glutathione reductase of human erythrocytes. Purification and properties. Scand. J. Clin. Lab. Invest. Suppl. 96, 1-67.
19. Jacobs RW, Farivar N, Butcher LL (1985) Alzheimer dementia and reduced nicotinamide adenine dinucleotide (NADH)-diaphorase activity in senile plaques and the basal forebrain. Neurosci. Lett. 53, 39-44.
20. Johnson WM, Wilson-Delfosse AL, Mieyal JJ (2012) Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients 4, 1399-1440.
21. Jones DP, Go YM (2010) Redox compartmentalization and cellular stress. Diabetes Obes. Metab. 12(Suppl 2), 116-125.
22. Kahraman S, Fiskum G (2007) Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes. Neurochem. Res. 32, 799-806.
23. Kamencic H, Lyon A, Paterson PG, Juurlink BH (2000) Monochlorobimane fluorometric method to measure tissue glutathione. Anal. Biochem. 286, 35-37.
24. Kaplin AI, Snyder SH, Linden DJ (1996) Reduced nicotinamide adenine dinucleotide-selective stimulation of inositol 1, 4, 5-trisphosphate receptors mediates hypoxic mobilization of calcium. J. Neurosci. 16, 2002-2011.
25. Kosower NS, Kosower EM (1978) The glutathione status of cells. Int. Rev. Cytol. 54, 109-160.
26. Liu D, Gharavi R, Pitta M, Gleichmann M, Mattson MP (2009) Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular. Med. 11, 28-42.
27. Liu LY, Wang F, Zhang XY, Huang P, Lu YB, Wei EQ, Zhang WP (2012) Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. PLoS ONE 7, e44933.
28. Nicholson RM, Kusne Y, Nowak LA, LaFerla FM, Reiman EM, Valla J (2010) Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models. Brain Res. 1347, 179-185.
29. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421.
30. Olgun A (2009) Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging. Biogerontology 10, 531-534.
31. Perez VI, Van Remmen H, Bokov A, Epstein CJ, Vijg J, Richardson A (2009) The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 8, 73-75.
32. Ravindranath V, Shivakumar BR, Anandatheerthavarada HK (1989) Low glutathione levels in brain regions of aged rats. Neurosci. Lett. 101, 187-190.
33. Rebrin I, Forster MJ, Sohal RS (2007) Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL/6 and DBA/2 mice. Brain Res. 1127, 10-18.
34. Rydstrom J (2006) Mitochondrial NADPH, transhydrogenase and disease. Biochim. Biophys. Acta 1757, 721-726.
35. Safdar A, deBeer J, Tarnopolsky MA (2010) Dysfunctional Nrf2-Keap1 redox signaling in skeletal muscle of the sedentary old. Free Radic. Biol. Med. 49, 1487-1493.
36. Sasaki Y, Araki T, Milbrandt J (2006) Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J. Neurosci. 26, 8484-8491.
37. Soong R, Beyser K, Basten O, Kalbe A, Rueschoff J, Tabiti K (2001) Quantitative reverse transcription-polymerase chain reaction detection of cytokeratin 20 in noncolorectal lymph nodes. Clin. Cancer Res. 7, 3423-3429.
38. Strosznajder JB, Czapski GA, Adamczyk A, Strosznajder RP (2012) Poly(ADP-ribose) polymerase-1 in amyloid beta toxicity and Alzheimer's disease. Mol. Neurobiol. 46, 78-84.
39. Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM (2004) Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc. Natl Acad. Sci. USA 101, 3381-3386.
40. van der Veer E, Ho C, O'Neil C, Barbosa N, Scott R, Cregan SP, Pickering JG (2007) Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J. Biol. Chem. 282, 10841-10845.
41. Walker MP, Laferla FM, Oddo SS, Brewer GJ (2012) Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age 35, 519-531.
42. Wang B, Hasan MK, Alvarado E, Yuan H, Wu H, Chen WY (2011) NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene 30, 907-921.
43. Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 106, 14670-14675.
44. Yin F, Sancheti H, Cadenas E (2012) Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Biochim. Biophys. Acta 1817, 401-409.
45. Zhang H, Limphong P, Pieper J, Liu Q, Rodesch CK, Christians E, Benjamin IJ (2012) Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity. FASEB J. 26, 1442-1451.
46. Zhu Y, Carvey PM, Ling Z (2006) Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res. 1090, 35-44.