Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Qian, Zhengjiang ^a   Wu, Zhiqin ^a   Huang, Lian ^a   Qiu, Huiling ^a   Wang, Liyan ^a   Li, Li ^a   Yao, Lijun ^a   Kang, Kang ^b   Qu, Junle ^a   Wu, Yonghou ^c   Luo, Jun ^c   Liu, Johnson J ^d   Yang, Yi ^b   Yang, Wancai ^e   Gou, Deming ^a  

^a SHENZHEN UNIVERSITY   (China)

^b Shenzhen University   (China)

^c NORTHWEST A F UNIVERSITY   (China)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e JINING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CYTOKINE; DEXTRAN SULFATE; ETHYL LINOLENATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LINOLEIC ACID; LINOLENIC ACID; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN 2; NITRIC OXIDE; PLANT EXTRACT;

ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; CELL TRANSFORMATION; CHEMISTRY; COLITIS; COLORECTAL NEOPLASMS; DEFICIENCY; DIETARY SUPPLEMENT; DISEASE MODEL; DRUG EFFECTS; FRUIT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MORUS; MOUSE; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; COLITIS; COLORECTAL NEOPLASMS; CYTOKINES; DEXTRAN SULFATE; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FRUIT; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; LINOLEIC ACID; LINOLENIC ACIDS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MORUS; MUCIN-2; NF-KAPPA B; NITRIC OXIDE; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 84948653927     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17348     Document Type: Article

References (55)

1. Huang, H. P., Ou, T. T., Wang, C. J. Mulberry (sang shen zi)-and its bioactive compounds, the chemoprevention effects and molecular mechanisms in vitro and in vivo. J.Tradit. Complement. Med. 3, 7-15 (2013).
2. Venkatesh, K. P., Chauhan, S. Mulberry: Life enhancer. J. Med. Plants Res. 2, 271-278 (2008).
3. Saurabh, B., Rao, A. B., Muthukumaran, M., Nagalakshmamma, K. History and active pharmacokinetic principles of mulberry: a review. IOSR J. Pharm. 2, 13-16 (2012).
4. Pratchaya, K. et al. Effects of Mulberry Fruit Powder in Animal Model of Stroke. Am. J. Agr. Biol. Sci. 7, 322-329 (2012).
5. Kim, H. G. et al. Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models. Br. J. Nutr. 104, 8-16 (2010).
6. Valacchi, G. et al. Effect of combined mulberry leaf and fruit extract on liver and skin cholesterol transporters in high fat dietinduced obese mice. Nutr. Res. Pract. 8, 20-26 (2014).
7. Liu, C. J., Lin, J. Y. Anti-inflammatory effects of phenolic extracts from strawberry and mulberry fruits on cytokine secretion profiles using mouse primary splenocytes and peritoneal macrophages. Int.l Immunopharmacol. 16, 165-170 (2013).
8. Jiang, D. Q. et al. Antioxidant and anti-fatigue effects of anthocyanins of mulberry juice purification (MJP) and mulberry marc purification (MMP) from different varieties mulberry fruit in China. Food Chem. Toxicol. 59, 1-7 (2013).
9. Stefanut, M. N. et al. Anti-hyperglycemic Effect of Bilberry, Blackberry and Mulberry Ultrasonic Extracts on Diabetic Rats. Plant Foods Hum. Nutr. 68, 378-384 (2013).
10. Wang, Y. et al. Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract. PloS One 8, e71144 (2013).
11. Lim, H. H. et al. Anti-inflammatory and antiobesity effects of mulberry leaf and fruit extract on high fat diet-induced obesity. Exp. Biol. Med. 238, 1160-1169 (2013).
12. Lin, J. Y., Tang, C. Y. Determination of total phenolic and flavonoid contents in selected fruits and vegetables, as well as their stimulatory effects on mouse splenocyte proliferation. Food Chem. 101, 140-147 (2007).
13. Ercisli, S., Orhan, E. Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits. Food Chem. 103, 1380-1384 (2007).
14. Song, W. et al. Phytochemical Profiles of Different Mulberry (Morus sp.) Species from China. J. Agr. Food Chem. 57, 9133-9140 (2009).
15. Molodecky, N. A. et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, Based on Systematic Review. Gastroenterology 142, 46-54 (2012).
16. Seo, G. S., Chae, S. C. Biological therapy for ulcerative colitis: An update. World J. Gastroenterol. 20, 13234-13238 (2014).
17. Ronnblom, A., Samuelsson, S. M., Ekbom, A. Ulcerative colitis in the county of Uppsala 1945-2007 Incidence and clinical characteristics. J. Crohns Colitis. 4, 532-536 (2010).
18. Boldeanu, M. V. et al. Investigation of inflammatory activity in ulcerative colitis. Rom. J. Morphol. Embryol. 55, 1345-1351 (2014).
19. Gracie, D. J., Ford, A. C. IBS-like symptoms in patients with ulcerative colitis. Clin. Exp. Gastroenterol. 8, 101-109 (2015).
20. Amiot, A., Peyrin, B. L. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. Therap. Adv. Gastroenterol. 8, 66-82 (2015).
21. Westbrook, A. M., Szakmary, A., Schiestl, R. H. Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models. Mutat. Res. 705, 40-59 (2010).
22. Terzic, J., Grivennikov, S., Karin, E., Karin, M. Inflammation and Colon Cancer. Gastroenterology 138, 2101-U2119 (2010).
23. Shi, N. et al. Strawberry Phytochemicals Inhibit Azoxymethane/Dextran Sodium Sulfate-Induced Colorectal Carcinogenesis in Crj: CD-1 Mice. Nutrients 7, 1696-1715 (2015).
24. Feagins, L. A., Souza, R. F., Spechler, S. J. Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer. Nat. Rev. Gastroenterol. Hepatol. 6, 297-305 (2009).
25. Bi, X. et al. Black Raspberries Inhibit Intestinal Tumorigenesis in Apc1638 +/and Muc2/Mouse Models of Colorectal Cancer. Cancer Prev. Res. 3, 1443-1450 (2010).
26. Siegel, R., Naishadham, D., Jemal, A. Cancer Statistics, 2012. CA Cancer J. Clin. 62, 10-29 (2012).
27. Takeuchi, O., Akira, S. Pattern Recognition Receptors and Inflammation. Cell 140, 805-820 (2010).
28. Guha, M., Mackman, N. LPS induction of gene expression in human monocytes. Cell. Signal. 13, 85-94 (2001).
29. Xiong, H., Cheng, Y., Zhang, X., Zhang, X. Effects of taraxasterol on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages. J. ethnopharmacol. 155, 753-757 (2014).
30. Serhan, C. N., Chiang, N., Van Dyke, T. E. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8, 349-361 (2008).
31. Li, L. et al. Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis. Sci. Rep. 4, (2014).
32. Velcich, A. et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295, 1726-1729 (2002).
33. Bao, Y. et al. MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation. PloS one. 9, e99132 (2014).
34. Zhang, X., Xiong. H., Liu, L. Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J. Ethnopharmacol. 141, 206-211 (2012).
35. Fan, X. et al. Trilobatin attenuates the LPS-mediated inflammatory response by suppressing the NF-kappaB signaling pathway. Food chem. 166, 609-615 (2015).
36. Joo, Y. E. et al. Tomato Lycopene Extract Prevents Lipopolysaccharide-Induced NF-kappa B Signaling but Worsens Dextran Sulfate Sodium-Induced Colitis in NF-kappa B-EGFP Mice. PloS One 4, e4562 (2009).
37. Soromou, L. W. et al. Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-kappa B signaling pathway. Biochem. Biophys. Res. Commun. 419, 256-261 (2012).
38. Hommes, D. W., Peppelenbosch, M. P., Van Deventer, S. J. H. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52, 144-151 (2003).
39. Lei, S. et al. Somatostatin ameliorates lipopolysaccharide-induced tight junction damage via the ERK-MAPK pathway in Caco2 cells. Eur. J. Cell Bio. 93, 299-307 (2014).
40. Alibin, C. P., Kopilas, M. A., Anderson, H. D. I. Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid-Role of peroxisome proliferator-activated receptors alpha and gamma. J. Biol. Chem. 283, 10707-10715 (2008).
41. Kuan, C. Y., Walker, T. H., Luo, P. G., Chen, C. F. Long-Chain Polyunsaturated Fatty Acids Promote Paclitaxel Cytotoxicity via Inhibition of the MDR1 Gene in the Human Colon Cancer Caco-2 Cell Line. J. Am. Coll. Nutr. 30, 265-273 (2011).
42. Dupertuis, Y. M., Meguid, M. M., Pichard, C. Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids. Curr. Opin. Clin. Nutr. Metab. Care 10, 427-432 (2007).
43. Das, U. N., Madhavi, N. Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro. Lipids Health Dis. 10, (2011).
44. Dilzer, A., Park, Y. Implication of Conjugated Linoleic Acid (CLA) in Human Health. Crit. Rev. Food Sci. Nutr. 52, 488-513 (2012).
45. Lu, X. et al. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. Lipids Health Dis. 9, 106-219 (2010).
46. Martinasso, G. et al. Conjugated linoleic acid prevents cell growth and cytokine production induced by TPA in human keratinocytes NCTC 2544. Cancer Lett. 287, 62-66 (2010).
47. Wirtz, S., Neufert, C., Weigmann, B., Neurath, M. F. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541-546 (2007).
48. Tschida, B. R., Largaespada, D. A., Keng, V. W. Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies. Semin. Cell De. Bio. 27, 86-95 (2014).
49. Sharpless, N. E., DePinho, R. A. Model organisms-The mighty mouse: genetically engineered mouse models in cancer drug development. Nat. Rev. Drug Discov. 5, 741-754 (2006).
50. Guzman, J. R. et al. Oxymatrine Prevents NF-kappa B Nuclear Translocation And Ameliorates Acute Intestinal Inflammation. Sci. Rep. 3, 9 (2013).
51. Zhang, L. et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 22, 107-126 (2012).
52. Mlotshwa, S. et al. A novel chemopreventive strategy based on therapeutic microRNAs produced in plants. Cell Res. 25, 521-524 (2015).
53. Yang, K. et al. Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: Potential role of chronic inflammation. Cancer Res. 68, 7313-7322 (2008).
54. Yang, W. C. et al. Inactivation of p21(WAF1/cip1) enhances intestinal tumor formation in Muc2(/) mice. Am. J. Pathol. 166, 1239-1246 (2005).
55. Shen, Y. et al. Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice. Clin Cancer Res. 21, 1466-1476 (2015).