메뉴 건너뛰기




Volumn 8, Issue 2, 2015, Pages 66-82

Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases

Author keywords

anti TNF agents; biologics; Crohn s disease; inflammatory bowel diseases; ulcerative colitis

Indexed keywords

ADALIMUMAB; ALICAFORSEN; ANRUKINZUMAB; AZATHIOPRINE; BERTILIMUMAB; CERTOLIZUMAB PEGOL; CPT 13; CYTOKINE RECEPTOR ANTAGONIST; ETROLIZUMAB; FILGOTINIB; FINGOLIMOD; GOLIMUMAB; INFLIXIMAB; INTERLEUKIN 6 ANTIBODY; JANUS KINASE INHIBITOR; LAQUINIMOD; MASITINIB; NATALIZUMAB; PEFICITINIB; PF 04236921; PLACEBO; QAX 576; TOFACITINIB; TRALOKINUMAB; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; USTEKINUMAB; VATELIZUMAB; VEDOLIZUMAB;

EID: 84922368916     PISSN: 1756283X     EISSN: 17562848     Source Type: Journal    
DOI: 10.1177/1756283X14558193     Document Type: Review
Times cited : (112)

References (89)
  • 1
    • 84922384011 scopus 로고    scopus 로고
    • Optimizing conventional medical therapies in inflammatory bowel disease
    • Sep 14 [Epub ahead of print].
    • Asthana A. Sparrow M. Peyrin-Biroulet L. (2014) Optimizing conventional medical therapies in inflammatory bowel disease. Cur Drug Targets Sep 14 [Epub ahead of print].
    • (2014) Cur Drug Targets
    • Asthana, A.1    Sparrow, M.2    Peyrin-Biroulet, L.3
  • 2
    • 79953786419 scopus 로고    scopus 로고
    • Loss of response and need for adalimumab dose intensification in Crohn's disease: a systematic review
    • Billioud V. Sandborn W. Peyrin-Biroulet L. (2011). Loss of response and need for adalimumab dose intensification in Crohn's disease: a systematic review. Am J Gastroenterol 106: 674–684.
    • (2011) Am J Gastroenterol , vol.106 , pp. 674-684
    • Billioud, V.1    Sandborn, W.2    Peyrin-Biroulet, L.3
  • 3
    • 84872001585 scopus 로고    scopus 로고
    • Role of mast cells in mucosal diseases: current concepts and strategies for treatment
    • Beunk L. Verwoerd A. van Overveld F. Rijkers G. (2013) Role of mast cells in mucosal diseases: current concepts and strategies for treatment. Expert Rev Clin Immunol 9: 53–63.
    • (2013) Expert Rev Clin Immunol , vol.9 , pp. 53-63
    • Beunk, L.1    Verwoerd, A.2    van Overveld, F.3    Rijkers, G.4
  • 4
    • 79955557278 scopus 로고    scopus 로고
    • Conventional medical management of inflammatory bowel disease
    • e1822.
    • Burger D. Travis S. (2011) Conventional medical management of inflammatory bowel disease. Gastroenterology 140: 1827–1837 e1822.
    • (2011) Gastroenterology , vol.140 , pp. 1827-1837
    • Burger, D.1    Travis, S.2
  • 5
    • 0036796777 scopus 로고    scopus 로고
    • Efficacy of a novel pegylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial
    • Choy E. Hazleman B. Smith M. Moss K. Lisi L. Scott D. et al. (2002) Efficacy of a novel pegylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial. Rheumatology (Oxford) 41: 1133–1137.
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 1133-1137
    • Choy, E.1    Hazleman, B.2    Smith, M.3    Moss, K.4    Lisi, L.5    Scott, D.6
  • 6
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial
    • http://www.ncbi.nlm.nih.gov/pubmed/17241859
    • Colombel J.F. Sandborn W.J. Rutgeerts P. Enns R. Hanauer S.B. Panaccione R. et al. (2007) Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. http://www.ncbi.nlm.nih.gov/pubmed/17241859 Gastroenterology 132: 52-65.
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, J.F.1    Sandborn, W.J.2    Rutgeerts, P.3    Enns, R.4    Hanauer, S.B.5    Panaccione, R.6
  • 7
    • 84858217865 scopus 로고    scopus 로고
    • Placebo-controlled trial of oral laquinimod for multiple sclerosis
    • Comi G. Jeffery D. Kappos L. Montalban X. Boyko A. Rocca M. et al. (2012) Placebo-controlled trial of oral laquinimod for multiple sclerosis. N Engl J Med 366: 1000–1009.
    • (2012) N Engl J Med , vol.366 , pp. 1000-1009
    • Comi, G.1    Jeffery, D.2    Kappos, L.3    Montalban, X.4    Boyko, A.5    Rocca, M.6
  • 8
    • 84882433613 scopus 로고    scopus 로고
    • Involvement of Jak / Stat signaling in the pathogenesis of inflammatory bowel disease
    • Coskun M. Salem M. Pedersen J. Nielsen O. (2013) Involvement of Jak / Stat signaling in the pathogenesis of inflammatory bowel disease. Pharmacol Res 76: 1–8.
    • (2013) Pharmacol Res , vol.76 , pp. 1-8
    • Coskun, M.1    Salem, M.2    Pedersen, J.3    Nielsen, O.4
  • 10
    • 84876586327 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors induce down-regulation of c-kit by targeting the ATP pocket
    • D'allard D. Gay J. Descarpentries C. Frisan E. Adam K. Verdier F. et al. (2013) Tyrosine kinase inhibitors induce down-regulation of c-kit by targeting the ATP pocket. PloS ONE 8: e60961.
    • (2013) PloS ONE , vol.8 , pp. e60961
    • D'allard, D.1    Gay, J.2    Descarpentries, C.3    Frisan, E.4    Adam, K.5    Verdier, F.6
  • 11
    • 84886293617 scopus 로고    scopus 로고
    • Safety and efficacy of laquinimod in inducing clinical and biochemical improvement in active Crohn's disease: results of an exploratory trial
    • D'haens G. Colombel J. Sandborn W. Rutgeerts P. Feagan B. (2013) Safety and efficacy of laquinimod in inducing clinical and biochemical improvement in active Crohn's disease: results of an exploratory trial. Gastroenterology 144: S21.
    • (2013) Gastroenterology , vol.144 , pp. S21
    • D'haens, G.1    Colombel, J.2    Sandborn, W.3    Rutgeerts, P.4    Feagan, B.5
  • 12
    • 79751472562 scopus 로고    scopus 로고
    • The London position of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?
    • D'haens G. Panaccione R. Higgins P. Vermeire S. Gassull M. Chowers Y. et al. (2011) The London position of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response? Am J Gastroenterol 106: 199–212.
    • (2011) Am J Gastroenterol , vol.106 , pp. 199-212
    • D'haens, G.1    Panaccione, R.2    Higgins, P.3    Vermeire, S.4    Gassull, M.5    Chowers, Y.6
  • 13
    • 84860557456 scopus 로고    scopus 로고
    • New therapies for inflammatory bowel disease: from the bench to the bedside
    • Danese S. (2012) New therapies for inflammatory bowel disease: from the bench to the bedside. Gut 61: 918–932.
    • (2012) Gut , vol.61 , pp. 918-932
    • Danese, S.1
  • 14
    • 84922355069 scopus 로고    scopus 로고
    • Tralokinumab (CAT-354), an interleukin 13 antibody, in moderate to severe ulcerative colitis: a phase 2a randomized placebo-controlled study
    • Danese S. Rudzinski J. Brandt W. Dupas J. Peyrin-Biroulet L. Bouhnik Y. et al. (2014) Tralokinumab (CAT-354), an interleukin 13 antibody, in moderate to severe ulcerative colitis: a phase 2a randomized placebo-controlled study. Gastroenterology 146: S149.
    • (2014) Gastroenterology , vol.146 , pp. S149
    • Danese, S.1    Rudzinski, J.2    Brandt, W.3    Dupas, J.4    Peyrin-Biroulet, L.5    Bouhnik, Y.6
  • 15
    • 50249187809 scopus 로고    scopus 로고
    • Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNFalpha
    • Delavallee L. Le Buanec H. Bessis N. Assier E. Denys A. Bizzini B. et al. (2008) Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNFalpha. Ann Rheum Dis 67: 1332–1338.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1332-1338
    • Delavallee, L.1    Le Buanec, H.2    Bessis, N.3    Assier, E.4    Denys, A.5    Bizzini, B.6
  • 16
    • 84886381351 scopus 로고    scopus 로고
    • Results of a phase II, randomized, double blind, controlled trial of the efficacy of active therapeutic immunization with TNF-Kinoid in patients with moderate to severe Crohn's disease with secondary resistance to TNFα antagonist
    • Dewit O. Hebuterne X. Dupas J. Howaldt S. Bures J. Schreiber S. et al. (2012) Results of a phase II, randomized, double blind, controlled trial of the efficacy of active therapeutic immunization with TNF-Kinoid in patients with moderate to severe Crohn's disease with secondary resistance to TNFα antagonist. Gastroenterology 142: S-567-S-568.
    • (2012) Gastroenterology , vol.142 , pp. S-567-S-568
    • Dewit, O.1    Hebuterne, X.2    Dupas, J.3    Howaldt, S.4    Bures, J.5    Schreiber, S.6
  • 17
    • 62949147825 scopus 로고    scopus 로고
    • European Medicines Agency
    • Guideline on Similar Biological Medicinal Products Containing Biotechnology-Derived Proteins as Active Substance: Non-Clinical and Clinical Issues Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/06/WC500144124.pdf
    • European Medicines Agency (2013) Guideline on Similar Biological Medicinal Products Containing Biotechnology-Derived Proteins as Active Substance: Non-Clinical and Clinical Issues. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/06/WC500144124.pdf.
    • (2013)
  • 18
    • 62949147825 scopus 로고    scopus 로고
    • European Medicines Agency
    • Inflectra – Summary of Opinion (Initial Authorisation) Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/002778/WC500144831.pdf
    • European Medicines Agency (2013) Inflectra – Summary of Opinion (Initial Authorisation). Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/002778/WC500144831.pdf.
    • (2013)
  • 19
    • 62949147825 scopus 로고    scopus 로고
    • European Medicines Agency
    • Refusal of the Marketing Authorisation for Xeljanz (Tofacitinib) Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/002542/WC500146629.pdf
    • European Medicines Agency (2013) Refusal of the Marketing Authorisation for Xeljanz (Tofacitinib). Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/002542/WC500146629.pdf.
    • (2013)
  • 20
    • 84878893109 scopus 로고
    • European Medicines Agency
    • Clinical trials register http://www.clinicaltrialsregister.eu (accessed June 2014).
    • European Medicines Agency (1995–2014) Clinical trials register. http://www.clinicaltrialsregister.eu (accessed June 2014).
    • (1995)
  • 21
    • 84892145631 scopus 로고    scopus 로고
    • Predictors of relapse in patients with ulcerative colitis in remission after one-year of infliximab therapy
    • Farkas K. Lakatos P. Nagy F. Szepes Z. Miheller P. Papp M. et al. (2013) Predictors of relapse in patients with ulcerative colitis in remission after one-year of infliximab therapy. Scand J Gastroenterol 48: 1394–1398.
    • (2013) Scand J Gastroenterol , vol.48 , pp. 1394-1398
    • Farkas, K.1    Lakatos, P.2    Nagy, F.3    Szepes, Z.4    Miheller, P.5    Papp, M.6
  • 22
    • 20444469332 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
    • Feagan B. Greenberg G. Wild G. Fedorak R. Pare P. Mcdonald J. et al. (2005) Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 352: 2499–2507.
    • (2005) N Engl J Med , vol.352 , pp. 2499-2507
    • Feagan, B.1    Greenberg, G.2    Wild, G.3    Fedorak, R.4    Pare, P.5    Mcdonald, J.6
  • 23
    • 57249089077 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin
    • Feagan B. Greenberg G. Wild G. Fedorak R. Pare P. Mcdonald J. et al. (2008 a) Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 6: 1370–1377.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1370-1377
    • Feagan, B.1    Greenberg, G.2    Wild, G.3    Fedorak, R.4    Pare, P.5    Mcdonald, J.6
  • 24
    • 55449098725 scopus 로고    scopus 로고
    • Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: results from the CHARM study
    • Feagan B. Panaccione R. Sandborn W. D'haens G. Schreiber S. Rutgeerts P. et al. (2008 b) Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: results from the CHARM study. Gastroenterology 135: 1493–1499.
    • (2008) Gastroenterology , vol.135 , pp. 1493-1499
    • Feagan, B.1    Panaccione, R.2    Sandborn, W.3    D'haens, G.4    Schreiber, S.5    Rutgeerts, P.6
  • 27
    • 60249084148 scopus 로고    scopus 로고
    • Ustekinumab, a human interleukin 12 / 23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial
    • Gottlieb A. Menter A. Mendelsohn A. Shen Y. Li S. Guzzo C. et al. (2009) Ustekinumab, a human interleukin 12 / 23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet 373: 633–640.
    • (2009) Lancet , vol.373 , pp. 633-640
    • Gottlieb, A.1    Menter, A.2    Mendelsohn, A.3    Shen, Y.4    Li, S.5    Guzzo, C.6
  • 29
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial
    • Hanauer S.B. Sandborn W.J. Rutgeerts P. Fedorak R.N. Lukas M. MacIntosh D. et al. (2006) Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 130: 323–333.
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3    Fedorak, R.N.4    Lukas, M.5    MacIntosh, D.6
  • 30
    • 84993727673 scopus 로고    scopus 로고
    • ICH
    • Comparability of biotechnological / biological products subject to changes in their manufacturing process The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Available at: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q5E/Step4/Q5E_Guideline.pdf
    • ICH (2004) Comparability of biotechnological / biological products subject to changes in their manufacturing process. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). Available at: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q5E/Step4/Q5E_Guideline.pdf
    • (2004)
  • 31
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • discussion 947.
    • Ito H. Takazoe M. Fukuda Y. Hibi T. Kusugami K. Andoh A. et al. (2004) A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126: 989–996; discussion 947.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3    Hibi, T.4    Kusugami, K.5    Andoh, A.6
  • 32
    • 84864438913 scopus 로고    scopus 로고
    • Golimumab in psoriatic arthritis: one-year clinical efficacy, radiographic, and safety results from a phase III, randomized, placebo-controlled trial
    • Kavanaugh A. van der Heijde D. Mcinnes I. Mease P. Krueger G. Gladman D. et al. (2012) Golimumab in psoriatic arthritis: one-year clinical efficacy, radiographic, and safety results from a phase III, randomized, placebo-controlled trial. Arthritis Rheum 64: 2504–2517.
    • (2012) Arthritis Rheum , vol.64 , pp. 2504-2517
    • Kavanaugh, A.1    van der Heijde, D.2    Mcinnes, I.3    Mease, P.4    Krueger, G.5    Gladman, D.6
  • 33
    • 42449157502 scopus 로고    scopus 로고
    • Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate: a randomized, double-blind, placebo-controlled, dose-ranging study
    • Kay J. Matteson E. Dasgupta B. Nash P. Durez P. Hall S. et al. (2008) Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate: a randomized, double-blind, placebo-controlled, dose-ranging study. Arthritis Rheum 58: 964–975.
    • (2008) Arthritis Rheum , vol.58 , pp. 964-975
    • Kay, J.1    Matteson, E.2    Dasgupta, B.3    Nash, P.4    Durez, P.5    Hall, S.6
  • 34
    • 22844439662 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
    • Kleinschmidt-Demasters B. Tyler K. (2005) Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 353: 369–374.
    • (2005) N Engl J Med , vol.353 , pp. 369-374
    • Kleinschmidt-Demasters, B.1    Tyler, K.2
  • 35
    • 22844445230 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
    • Langer-Gould A. Atlas S. Green A. Bollen A. Pelletier D. (2005) Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 353: 375–381.
    • (2005) N Engl J Med , vol.353 , pp. 375-381
    • Langer-Gould, A.1    Atlas, S.2    Green, A.3    Bollen, A.4    Pelletier, D.5
  • 37
    • 0025854524 scopus 로고
    • Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins
    • Lawrence M. Springer T. (1991) Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65: 859–873.
    • (1991) Cell , vol.65 , pp. 859-873
    • Lawrence, M.1    Springer, T.2
  • 38
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi C. Kimball A. Papp K. Yeilding N. Guzzo C. Wang Y. et al. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371: 1665–1674.
    • (2008) Lancet , vol.371 , pp. 1665-1674
    • Leonardi, C.1    Kimball, A.2    Papp, K.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6
  • 40
    • 70450195261 scopus 로고    scopus 로고
    • Controlling the cost of innovative cancer therapeutics
    • Malik N. (2009) Controlling the cost of innovative cancer therapeutics. Nat Rev Clin Oncol 6: 550–552.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 550-552
    • Malik, N.1
  • 41
    • 84868688331 scopus 로고    scopus 로고
    • Interleukin 13 and its role in gut defence and inflammation
    • Mannon P. Reinisch W. (2012) Interleukin 13 and its role in gut defence and inflammation. Gut 61: 1765–1773.
    • (2012) Gut , vol.61 , pp. 1765-1773
    • Mannon, P.1    Reinisch, W.2
  • 42
    • 84873646726 scopus 로고    scopus 로고
    • HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and Th1/Th17 responses
    • Michelsen K. Wong M. Ko B. Thomas L. Dhall D. Targan S. (2013) HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and Th1/Th17 responses. Inflamm Bowel Dis 19: 151–164.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 151-164
    • Michelsen, K.1    Wong, M.2    Ko, B.3    Thomas, L.4    Dhall, D.5    Targan, S.6
  • 43
    • 84859439270 scopus 로고    scopus 로고
    • Phase I clinical trial of Smad 7 knockdown using antisense oligonucleotide in patients with active Crohn's disease
    • Monteleone G. Fantini M. Onali S. Zorzi F. Sancesario G. Bernardini S. et al. (2012) Phase I clinical trial of Smad 7 knockdown using antisense oligonucleotide in patients with active Crohn's disease. Mol Ther 20: 870–876.
    • (2012) Mol Ther , vol.20 , pp. 870-876
    • Monteleone, G.1    Fantini, M.2    Onali, S.3    Zorzi, F.4    Sancesario, G.5    Bernardini, S.6
  • 45
    • 34548190038 scopus 로고    scopus 로고
    • Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance
    • Mudter J. Neurath M. (2007) Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm Bowel Dis 13: 1016–1023.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1016-1023
    • Mudter, J.1    Neurath, M.2
  • 46
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp K. Langley R. Lebwohl M. Krueger G. Szapary P. Yeilding N. et al. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 371: 1675–1684.
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.1    Langley, R.2    Lebwohl, M.3    Krueger, G.4    Szapary, P.5    Yeilding, N.6
  • 47
    • 84863984524 scopus 로고    scopus 로고
    • Vedolizumab for the treatment of active ulcerative colitis: a randomized controlled phase 2 dose-ranging study
    • Parikh A. Leach T. Wyant T. Scholz C. Sankoh S. Mould D. et al. (2012) Vedolizumab for the treatment of active ulcerative colitis: a randomized controlled phase 2 dose-ranging study. Inflamm Bowel Dis 18: 1470–1479.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1470-1479
    • Parikh, A.1    Leach, T.2    Wyant, T.3    Scholz, C.4    Sankoh, S.5    Mould, D.6
  • 48
    • 84883746909 scopus 로고    scopus 로고
    • A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: The PLANETAS Study
    • Park W. Hrycaj P. Jeka S. Kovalenko V. Lysenko G. Miranda P. et al. (2013) A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: The PLANETAS Study. Ann Rheum Dis 72: 1605–1612.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1605-1612
    • Park, W.1    Hrycaj, P.2    Jeka, S.3    Kovalenko, V.4    Lysenko, G.5    Miranda, P.6
  • 49
    • 46149125761 scopus 로고    scopus 로고
    • Crohn's disease: beyond antagonists of tumor necrosis factor
    • Peyrin-Biroulet L. (2008) Crohn's disease: beyond antagonists of tumor necrosis factor. Lancet 372: 67–81.
    • (2008) Lancet , vol.372 , pp. 67-81
    • Peyrin-Biroulet, L.1
  • 50
    • 84855216805 scopus 로고    scopus 로고
    • Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health. International Programme to Develop New Indexes for Crohn's Disease (IPNIC) group
    • Peyrin-Biroulet L. Cieza A. Sandborn W.J. Coenen M. Chowers Y. Hibi T. et al. (2012) Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health. International Programme to Develop New Indexes for Crohn's Disease (IPNIC) group. Gut 61: 241–247.
    • (2012) Gut , vol.61 , pp. 241-247
    • Peyrin-Biroulet, L.1    Cieza, A.2    Sandborn, W.J.3    Coenen, M.4    Chowers, Y.5    Hibi, T.6
  • 51
    • 76349114941 scopus 로고    scopus 로고
    • The natural history of adult Crohn's disease in population-based cohorts
    • Peyrin-Biroulet L. Loftus E. Jr Colombel J. Sandborn W. (2009) The natural history of adult Crohn's disease in population-based cohorts. Am J Gastroenterol 105: 289–297.
    • (2009) Am J Gastroenterol , vol.105 , pp. 289-297
    • Peyrin-Biroulet, L.1    Loftus, E.2    Colombel, J.3    Sandborn, W.4
  • 52
    • 84877276662 scopus 로고    scopus 로고
    • Disease-modifying anti-inflammatory bowel disease drugs (DMAIDs): the missing term in the literature
    • Peyrin-Biroulet L. (2013) Disease-modifying anti-inflammatory bowel disease drugs (DMAIDs): the missing term in the literature. Am J Gastroenterol 108: 859–860.
    • (2013) Am J Gastroenterol , vol.108 , pp. 859-860
    • Peyrin-Biroulet, L.1
  • 53
    • 84876495103 scopus 로고    scopus 로고
    • Tofacitinib: Janus bifrons in ulcerative colitis treatment
    • Peyrin-Biroulet L. Danese S. (2013) Tofacitinib: Janus bifrons in ulcerative colitis treatment. Gastroenterology 144: 1136–1138.
    • (2013) Gastroenterology , vol.144 , pp. 1136-1138
    • Peyrin-Biroulet, L.1    Danese, S.2
  • 55
    • 84908290574 scopus 로고    scopus 로고
    • Discrepancy between fecal biomarkers and their intestinal gene expression in ulcerative colitis: results from an anti-IL-13 antibody study
    • Reinisch W. Panes J. Page K. Khurana S. Hua F. Comer G. et al. (2014) Discrepancy between fecal biomarkers and their intestinal gene expression in ulcerative colitis: results from an anti-IL-13 antibody study. J Crohns Colitis 8: S283.
    • (2014) J Crohns Colitis , vol.8 , pp. S283
    • Reinisch, W.1    Panes, J.2    Page, K.3    Khurana, S.4    Hua, F.5    Comer, G.6
  • 56
    • 77956165442 scopus 로고    scopus 로고
    • Inhibition of Jak kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes
    • Riese R. Krishnaswami S. Kremer J. (2010) Inhibition of Jak kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes. Best Pract Res Clin Rheumatol 24: 513–526.
    • (2010) Best Pract Res Clin Rheumatol , vol.24 , pp. 513-526
    • Riese, R.1    Krishnaswami, S.2    Kremer, J.3
  • 60
    • 78049514932 scopus 로고    scopus 로고
    • Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis
    • Sandborn W. Colombel J. Frankel M. Hommes D. Lowder J. Mayer L. et al. (2010) Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis. Gut 59: 1485–1492.
    • (2010) Gut , vol.59 , pp. 1485-1492
    • Sandborn, W.1    Colombel, J.2    Frankel, M.3    Hommes, D.4    Lowder, J.5    Mayer, L.6
  • 61
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • Sandborn W. Feagan B. Fedorak R. Scherl E. Fleisher M. Katz S. et al. (2008) A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 135: 1130–1141.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.1    Feagan, B.2    Fedorak, R.3    Scherl, E.4    Fleisher, M.5    Katz, S.6
  • 62
    • 84890620601 scopus 로고    scopus 로고
    • Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis
    • quiz e14–85.
    • Sandborn W. Feagan B. Marano C. Zhang H. Strauss R. Johanns J. et al. (2014 a) Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology 146: 85–95; quiz e14–85.
    • (2014) Gastroenterology , vol.146 , pp. 85-95
    • Sandborn, W.1    Feagan, B.2    Marano, C.3    Zhang, H.4    Strauss, R.5    Johanns, J.6
  • 63
    • 84890629055 scopus 로고    scopus 로고
    • Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis
    • e101.
    • Sandborn W. Feagan B. Marano C. Zhang H. Strauss R. Johanns J. et al. (2014 b) Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis. Gastroenterology 146: 96–109 e101.
    • (2014) Gastroenterology , vol.146 , pp. 96-109
    • Sandborn, W.1    Feagan, B.2    Marano, C.3    Zhang, H.4    Strauss, R.5    Johanns, J.6
  • 65
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn W. Gasink C. Gao L. Blank M. Johanns J. Guzzo C. et al. (2012 a) Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 367: 1519–1528.
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.1    Gasink, C.2    Gao, L.3    Blank, M.4    Johanns, J.5    Guzzo, C.6
  • 66
    • 84865013186 scopus 로고    scopus 로고
    • Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
    • Sandborn W. Ghosh S. Panes J. Vranic I. Su C. Rousell S. et al. (2012 b) Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med 367: 616–624.
    • (2012) N Engl J Med , vol.367 , pp. 616-624
    • Sandborn, W.1    Ghosh, S.2    Panes, J.3    Vranic, I.4    Su, C.5    Rousell, S.6
  • 67
    • 84890629055 scopus 로고    scopus 로고
    • Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis
    • Sandborn W.J. Feagan B.G. Marano C. Zhang H. Strauss R. Johanns J. et al. (2014) Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis. Gastroenterology 146: 96–109.
    • (2014) Gastroenterology , vol.146 , pp. 96-109
    • Sandborn, W.J.1    Feagan, B.G.2    Marano, C.3    Zhang, H.4    Strauss, R.5    Johanns, J.6
  • 68
    • 34347402306 scopus 로고    scopus 로고
    • Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial
    • Sandborn W.J. Rutgeerts P. Enns R. Hanauer S.B. Colombel J.F. Panaccione R. et al. (2007) Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med 146: 829–838.
    • (2007) Ann Intern Med , vol.146 , pp. 829-838
    • Sandborn, W.J.1    Rutgeerts, P.2    Enns, R.3    Hanauer, S.B.4    Colombel, J.F.5    Panaccione, R.6
  • 69
    • 84856163835 scopus 로고    scopus 로고
    • Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis
    • Sandborn W.J. van Assche G. Reinisch W. Colombel J.F. D'Haens G. Wolf D.C. et al. (2012) Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology 142: 257–265.
    • (2012) Gastroenterology , vol.142 , pp. 257-265
    • Sandborn, W.J.1    van Assche, G.2    Reinisch, W.3    Colombel, J.F.4    D'Haens, G.5    Wolf, D.C.6
  • 70
    • 84879443839 scopus 로고    scopus 로고
    • Vedolizumab induction therapy for patients with Crohn's disease and prior anti-tumour necrosis factor antagonist failure: a randomised, placebo-controlled, double-blind, multicentre trial
    • Sands B. Feagan B. Rutgeerts P. Colombel J. Sandborn W. Sy R. et al. (2013) Vedolizumab induction therapy for patients with Crohn's disease and prior anti-tumour necrosis factor antagonist failure: a randomised, placebo-controlled, double-blind, multicentre trial. J Crohns Colitis 7: S5–S6.
    • (2013) J Crohns Colitis , vol.7 , pp. S5-S6
    • Sands, B.1    Feagan, B.2    Rutgeerts, P.3    Colombel, J.4    Sandborn, W.5    Sy, R.6
  • 71
    • 34447515607 scopus 로고    scopus 로고
    • Maintenance therapy with certolizumab pegol for Crohn's disease
    • http://www.ncbi.nlm.nih.gov/pubmed/17634459
    • Schreiber S. Khaliq-Kareemi M. Lawrance I.C. Thomsen O.Ø. Hanauer S.B. McColm J. et al. (2007) Maintenance therapy with certolizumab pegol for Crohn's disease. http://www.ncbi.nlm.nih.gov/pubmed/17634459 N Engl J Med 357: 239–250.
    • (2007) N Engl J Med , vol.357 , pp. 239-250
    • Schreiber, S.1    Khaliq-Kareemi, M.2    Lawrance, I.C.3    Thomsen, O.Ø.4    Hanauer, S.B.5    McColm, J.6
  • 72
    • 24144483087 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease
    • http://www.ncbi.nlm.nih.gov/pubmed/?term=schreiber+2005+certolizumab
    • Schreiber S. Rutgeerts P. Fedorak R.N. Khaliq-Kareemi M. Kamm M.A. Boivin M. et al. (2005) A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease. Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/?term=schreiber+2005+certolizumab 129: 807–818.
    • (2005) Gastroenterology , vol.129 , pp. 807-818
    • Schreiber, S.1    Rutgeerts, P.2    Fedorak, R.N.3    Khaliq-Kareemi, M.4    Kamm, M.A.5    Boivin, M.6
  • 74
    • 34247884424 scopus 로고    scopus 로고
    • Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial
    • Targan S. Feagan B. Fedorak R. Lashner B. Panaccione R. Present D. et al. (2007) Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology 132: 1672–1683.
    • (2007) Gastroenterology , vol.132 , pp. 1672-1683
    • Targan, S.1    Feagan, B.2    Fedorak, R.3    Lashner, B.4    Panaccione, R.5    Present, D.6
  • 75
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA 2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA 2 Study Group
    • Targan S.R. Hanauer S.B. van Deventer S.J. Mayer L. Present D.H. Braakman T. et al. (1997) A short-term study of chimeric monoclonal antibody cA 2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA 2 Study Group. N Engl J Med 337: 1029–1035.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    van Deventer, S.J.3    Mayer, L.4    Present, D.H.5    Braakman, T.6
  • 76
    • 67649890634 scopus 로고    scopus 로고
    • Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study
    • Tebib J. Mariette X. Bourgeois P. Flipo R. Gaudin P. Le Loet X. et al. (2009) Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study. Arthritis Res Ther 11: R95.
    • (2009) Arthritis Res Ther , vol.11 , pp. R95
    • Tebib, J.1    Mariette, X.2    Bourgeois, P.3    Flipo, R.4    Gaudin, P.5    Le Loet, X.6
  • 77
    • 77954632352 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Natalizumab: Highlights of Prescribing Information Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/125104s106lbl.pdf
    • US Food and Drug Administration (2009) Natalizumab: Highlights of Prescribing Information. Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/125104s106lbl.pdf
    • (2009)
  • 78
    • 0005248386 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Advisory Committee Meeting. Tofacitinib for the Treatment of Rheumatoid Arthritis. NDA 203214 Briefing Document. Available at: http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/arthritisadvisorycommittee/ucm302960.pdf
    • US Food and Drug Administration (2012) Advisory Committee Meeting. Tofacitinib for the Treatment of Rheumatoid Arthritis. NDA 203214. Briefing Document. Available at: http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/arthritisadvisorycommittee/ucm302960.pdf.
    • (2012)
  • 79
    • 77954632352 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Draft Guidance on Biosimilar Product Development Available at
    • US Food and Drug Administration (2013) Draft Guidance on Biosimilar Product Development. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/TherapeuticBiologicApplications/Biosimilars/default.html.
    • (2013)
  • 80
    • 0345308734 scopus 로고    scopus 로고
    • US National Institutes of Health
    • Clinicaltrials.Gov http://www.clinicaltrials.gov (accessed June 2014).
    • US National Institutes of Health (2011) Clinicaltrials.Gov. http://www.clinicaltrials.gov (accessed June 2014).
    • (2011)
  • 81
    • 22844445587 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
    • van Assche G. van Ranst M. Sciot R. Dubois B. Vermeire S. Noman M. et al. (2005) Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 353: 362–368.
    • (2005) N Engl J Med , vol.353 , pp. 362-368
    • van Assche, G.1    van Ranst, M.2    Sciot, R.3    Dubois, B.4    Vermeire, S.5    Noman, M.6
  • 82
    • 84908655755 scopus 로고    scopus 로고
    • Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis
    • in press
    • Varrin-Doyer M. Zamvil S. Schulze-Topphoff U. (2014) Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis. Exp Neurol, in press:
    • (2014) Exp Neurol
    • Varrin-Doyer, M.1    Zamvil, S.2    Schulze-Topphoff, U.3
  • 83
    • 84904857048 scopus 로고    scopus 로고
    • Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial
    • in press.
    • Vermeire S. O'byrne S. Keir M. Williams M. Lu T. Mansfield J. et al. (2014) Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet, in press.
    • (2014) Lancet
    • Vermeire, S.1    O'byrne, S.2    Keir, M.3    Williams, M.4    Lu, T.5    Mansfield, J.6
  • 84
    • 0032904627 scopus 로고    scopus 로고
    • Mechanisms that regulate the function of the selectins and their ligands
    • Vestweber D. Blanks J. (1999) Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev 79: 181–213.
    • (1999) Physiol Rev , vol.79 , pp. 181-213
    • Vestweber, D.1    Blanks, J.2
  • 85
    • 84864124859 scopus 로고    scopus 로고
    • IL-12 family cytokines: immunological playmakers
    • Vignali D. Kuchroo V. (2012) IL-12 family cytokines: immunological playmakers. Nat Immunol 13: 722–728.
    • (2012) Nat Immunol , vol.13 , pp. 722-728
    • Vignali, D.1    Kuchroo, V.2
  • 87
    • 84903394090 scopus 로고    scopus 로고
    • Mast cell secretory granules: armed for battle
    • Wernersson S. Pejler G. (2014) Mast cell secretory granules: armed for battle. Nat Rev Immunol 14: 478–494.
    • (2014) Nat Rev Immunol , vol.14 , pp. 478-494
    • Wernersson, S.1    Pejler, G.2
  • 88
    • 84883752718 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: The PLANETRA Study
    • Yoo D. Hrycaj P. Miranda P. Ramiterre E. Piotrowski M. Shevchuk S. et al. (2013) A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: The PLANETRA Study. Ann Rheum Dis 72: 1613–1620.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1613-1620
    • Yoo, D.1    Hrycaj, P.2    Miranda, P.3    Ramiterre, E.4    Piotrowski, M.5    Shevchuk, S.6
  • 89
    • 33847167546 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis
    • Zhou H. Jang H. Fleischmann R. Bouman-Thio E. Xu Z. Marini J. et al. (2007) Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis. J Clin Pharmacol 47: 383–396.
    • (2007) J Clin Pharmacol , vol.47 , pp. 383-396
    • Zhou, H.1    Jang, H.2    Fleischmann, R.3    Bouman-Thio, E.4    Xu, Z.5    Marini, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.