Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes

International Immunopharmacology

Volumn 29, Issue 2, 2015, Pages 748-760

  Chen, Feihu ^a   Zhou, Renpeng ^a   Wu, Xiaoshan ^a   Wang, Zhisen ^a   Ge, Jinfang ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Acid sensing ion channel 1a (ASIC1a); Apoptosis; Articular chondrocytes; IL 6; Rheumatoid arthritis

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ACID SENSING ION CHANNEL BLOCKING AGENT; CALCIUM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE 2; LACTATE DEHYDROGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PSALMOTOXIN 1; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TOCILIZUMAB; UNCLASSIFIED DRUG; ACID; APOPTOSIS REGULATORY PROTEIN; ASIC1 PROTEIN, RAT; MONOCLONAL ANTIBODY; PCTX1 PROTEIN, PSALMOPOEUS CAMBRIDGEI; PEPTIDE; SPIDER VENOM;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME RELEASE; FEMALE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; BIOSYNTHESIS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; MALE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ACID SENSING ION CHANNELS; ACIDS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; INTERLEUKIN-6; L-LACTATE DEHYDROGENASE; MALE; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SPIDER VENOMS; UP-REGULATION;

EID: 84948580732     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.08.044     Document Type: Article

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