Inhibition of acid-sensing ion channels by amiloride protects rat articular chondrocytes from acid-induced apoptosis via a mitochondrial-mediated pathway

Cell Biology International

Volumn 36, Issue 7, 2012, Pages 635-641

  Rong, Chao ^a   Chen, Fei Hu ^a   Jiang, Sheng ^a   Hu, Wei ^a   Wu, Fan Rong ^a   Chen, Tian Yi ^b   Yuan, Feng Lai ^c  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b HEFEI UNIVERSITY OF TECHNOLOGY   (China)

^c NANTONG UNIVERSITY   (China)

Author keywords

Acid sensing ion channel (ASIC); Acidosis; Amiloride; Apoptosis; Articular CHONDROCYTES; Rheumatoid arthritis

Indexed keywords

ACID SENSING ION CHANNEL; AMILORIDE; CASPASE 3; CASPASE 9; MESSENGER RNA; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; IN VITRO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMILORIDE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELLS, CULTURED; CHONDROCYTES; DIURETICS; HYDROGEN-ION CONCENTRATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS;

RATTUS;

EID: 84862900926     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20110432     Document Type: Article

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