Melittin enhances apoptosis through suppression of IL-6/sIL-6R complex-induced NF-κB and STAT3 activation and Bcl-2 expression for human fibroblast-like synoviocytes in rheumatoid arthritis

Joint Bone Spine

Volumn 78, Issue 5, 2011, Pages 471-477

  Kim, Seong Kyu ^a   Park, Ki Yeun ^a   Yoon, Wern Chan ^a   Park, Sung Hoon ^a   Park, Kwan Kyu ^a   Yoo, Dae Hyun ^b   Choe, Jung Yoon ^a  

^a Catholic University of Daegu   (South Korea)

^b Hanyang University Hospital for Rheumatic Diseases   (South Korea)

Author keywords

Apoptosis; IL 6; Melittin; NF B; STAT3; Synoviocyte

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CYTOCHROME C; I KAPPA B; INTERLEUKIN 6; MELITTIN; PROTEIN BCL 2; STAT3 PROTEIN;

APOPTOSIS; ARTICLE; CELL VIABILITY; COLORIMETRY; CYTOKINE RESPONSE; DNA FRAGMENTATION; DNA STRAND BREAKAGE; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; WESTERN BLOTTING;

APOPTOSIS; ARTHRITIS, RHEUMATOID; CASPASE 3; CASPASE 8; CELL SURVIVAL; CELLS, CULTURED; FIBROBLASTS; HUMANS; INTERLEUKIN-6; MELITTEN; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SYNOVIAL MEMBRANE;

EID: 80053438924     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2011.01.004     Document Type: Article

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