Transition State Charge Stabilization and Acid-Base Catalysis of mRNA Cleavage by the Endoribonuclease RelE

Biochemistry

Volumn 54, Issue 47, 2015, Pages 7048-7057

  Dunican, Brian F ^a   Hiller, David A ^a   Strobel, Scott A ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; NUCLEIC ACIDS; QUANTUM CHEMISTRY; RATE CONSTANTS; STABILIZATION;

ACID-BASE CATALYSIS; ACTIVE SITE RESIDUES; AMINO ACID STARVATIONS; ANTIBIOTIC RESISTANCE; CATALYTIC MECHANISMS; CHARGE STABILIZATION; POSITIVELY CHARGED; PROTEIN TRANSLATION;

CATALYSIS;

ALANINE; BACTERIAL TOXIN; BACTERIAL TOXIN RELE; GLUTAMIC ACID; HISTIDINE; MESSENGER RNA; PHOSPHOROTHIOIC ACID; RIBONUCLEASE; UNCLASSIFIED DRUG; ESCHERICHIA COLI PROTEIN; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; RELE PROTEIN, E COLI;

ACID BASE CATALYSIS; ANTIBIOTIC RESISTANCE; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GENE MUTATION; KINETICS; KWASHIORKOR; NONHUMAN; PH; PRIORITY JOURNAL; RATE CONSTANT; RIBOSOME; RNA CLEAVAGE; SINGLE TURNOVER KINETIC ANALYSIS; STEREOISOMERISM; WILD TYPE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR MODEL; MUTATION;

BACTERIAL TOXINS; CATALYTIC DOMAIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MUTATION; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RNA, MESSENGER;

EID: 84948446914     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00866     Document Type: Article

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