Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin- regulation of GSK3β

Molecular Endocrinology

Volumn 26, Issue 11, 2012, Pages 1808-1820

  Mao, Lulu ^a   Dauchy, Robert T ^a   Blask, David E ^a   Slakey, Lauren M ^a   Xiang, Shulin ^a   Yuan, Lin ^a   Dauchy, Erin M ^a   Shan, Bin ^a   Brainard, George C ^b   Hanifin, John P ^b   Frasch, Tripp ^a   Duplessis, Tamika T ^a   Hill, Steven M ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; MELATONIN; PROTEIN KINASE B;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INCIDENCE; CANCER PATIENT; CELL PROLIFERATION; CELL SURVIVAL; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; METASTASIS; NONHUMAN; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; PINEAL BODY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SLEEP DISORDER;

ANIMALS; BETA CATENIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CIRCADIAN RHYTHM; ENZYME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LIGHT; MALE; MELATONIN; MODELS, BIOLOGICAL; PHOSPHORYLATION; PHOSPHOSERINE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; TRANSCRIPTION FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS; YOUNG ADULT;

RATTUS;

EID: 84868107443     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1071     Document Type: Article

References (43)

1. Hay ED 2005 The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn 233:706-720
2. Thiery JP 2002 Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2:442-454
3. Willipinski-Stapelfeldt B, Riethdorf S, Assmann V, Woelfle U, Rau T, Sauter G, Heukeshoven J, Pantel K 2005 Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clin Cancer Res 11:8006-8014
4. Tomaskovic-Crook E, Thompson EW, Thiery JP 2009 Epithelial to mesenchymal transition and breast cancer. Breast Cancer Res 11: 213
5. van Es JH, Barker N, Clevers H 2003 You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Curr Opin Genet Dev 13:28-33
6. ten Berge D, Koole W, Fuerer C, Fish M, Eroglu E, Nusse R 2008 Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell 3:508-518
7. Gilles C, Polette M, Mestdagt M, Nawrocki-Raby B, Ruggeri P, Birembaut P, Foidart JM 2003 Transactivation of vimentin by β-catenin in human breast cancer cells. Cancer Res 63:2658-2664
8. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, HungMC 2004 Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6:931-940
9. Dickson RB, Johnson MD, el-Ashry D, Shi YE, Bano M, Zugmaier G, Ziff B, Lippman ME, Chrysogelos S 1993 Breast cancer: influence of endocrine hormones, growth factors and genetic alterations. Adv Exp Med Biol 330:119-141
10. Osborne CK 1998 Steroid hormone receptors in breast cancer management. Breast Cancer Res Treat 51:227-238
11. Hill SM, Frasch T, Xiang S, Yuan L, Duplessis T, Mao L 2009 Molecular mechanisms of melatonin anticancer effects. Integr Cancer Ther 8:337-346
12. Reiter RJ, Tan DX, Fuentes-Broto L 2010 Melatonin: a multitasking molecule. Prog Brain Res 181:127-151
13. Brainard GC, Rollag MD, Hanifin JP 1997 Photic regulation of melatonin in humans: ocular and neural signal transduction. J Biol Rhythms 12:537-546
14. Reiter RJ 1991 Melatonin: the chemical expression of darkness. Mol Cell Endocrinol 79:153-158
15. Hill SM, Blask DE 1988 Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res 48:6121-6126
16. Teplitzky SR, Kiefer TL, Cheng Q, Dwivedi PD, Moroz K, Myers L, Anderson MB, Collins A, Dai J, Yuan L, Spriggs LL, Blask DE, Hill SM 2001 Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. Cancer Lett 168:155-163
17. Yuan L, Collins AR, Dai J, Dubocovich ML, Hill SM 2002 MT 1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells. Mol Cell Endocrinol 192:147-156
18. Mao L, Yuan L, Slakey LM, Jones FE, Burow ME, Hill SM 2010 Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway. Breast Cancer Res 12:R 107
19. Cos S, Fernández R, Güézmes A, Sánchez-Barceló EJ 1998 Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res 58:4383-4390
20. Blask DE, Brainard GC, Dauchy RT, Hanifin JP, Davidson LK, Krause JA, Sauer LA, Rivera-Bermudez MA, Dubocovich ML, Jasser SA, Lynch DT, Rollag MD, Zalatan F 2005 Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Cancer Res 65:11174-11184
21. Wu J, Dauchy RT, Tirrell PC, Wu SS, Lynch DT, Jitawatanarat P, Burrington CM, Dauchy EM, Blask DE, GreeneMW 2011 Light at night activates IGF-1R/PDK 1 signaling and accelerates tumor growth in human breast cancer xenografts. Cancer Res 71:2622-2631
22. Hughes K, Nikolakaki E, Plyte SE, Totty NF, Woodgett JR 1993 Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J 12:803-808
23. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA 1995 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789
24. Dauchy RT, Blask DE, Dauchy EM, Davidson LK, Tirrell PC, Greene MW, Tirrell RP, Hill CR, Sauer LA 2009 Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. J Pineal Res 47:32-42
25. Martín V, Herrera F, Carrera-Gonzalez P, García-Santos G, Antolín I, Rodriguez-Blanco J, Rodriguez C 2006 Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin. Cancer Res 66:1081-1088
26. Dauchy RT, Sauer LA 1986 Preparation of "tissue-isolated" rat tumors for perfusion: a new surgical technique that preserves continuous blood flow. Lab Anim Sci 36:678-681
27. Sonderegger S, Haslinger P, Sabri A, Leisser C, Otten JV, Fiala C, Knöfler M 2010 Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation. Endocrinology 151: 211-220
28. Anbalagan M, Carrier L, Glodowski S, Hangauer D, Shan B, Rowan BG 2012 KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor β positive breast cancer. Breast Cancer Res Treat 132: 391-409
29. Cailotto C, Lei J, van der Vliet J, van Heijningen C, van Eden CG, Kalsbeek A, Pévet P, Buijs RM 2009 Effects of nocturnal light on (clock) gene expression in peripheral organs: a role for the autonomic innervation of the liver. PLoS One 4:e5650
30. Xiang S, Mao L, Duplessis T, Yuan L, Dauchy R, Dauchy E, Blask DE, Frasch T, Hill SM 2012 Oscillation of clock and clock controlled genes induced by serum shock and regulated by melatonin in human breast epithelial and breast cancer cells. Breast Cancer (Auckl) 6:137-150
31. Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Rubin JS, Perrella MA, Lee ME 2001 Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem 276:17479-17483
32. Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M 2008 Phosphorylation by p38 MAPK as an alternative pathway for GSK 3β inactivation. Science 320:667-670
33. Lai L, Yuan L, Chen Q, Dong C, Mao L, Rowan B, Frasch T, Hill SM 2008 The Gαi and Gαq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation. J Pineal Res 45:476-488
34. Ram PT, Dai J, Yuan L, Dong C, Kiefer TL, Lai L, Hill SM 2002 Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett 179:141-150
35. Xu Y, Lee SH, Kim HS, Kim NH, Piao S, Park SH, Jung YS, Yook JI, Park BJ, Ha NC 2010 Role of CK 1 in GSK 3β-mediated phosphorylation and degradation of snail. Oncogene 29:3124-3133
36. Parkin DM, Läärä E, Muir CS 1988 Estimates of worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41:184-197
37. Stevens RG 1987 Electric power use and breast cancer: a hypothesis. Am J Epidemiol 125:556-561
38. Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Altieri A, Benbrahim-Tallaa L, Cogliano V 2007 Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol 8:1065-1066
39. Iitaka C, Miyazaki K, Akaike T, Ishida N 2005 A role for glycogen synthase kinase-3β in the mammalian circadian clock. J Biol Chem 280:29397-29402
40. Henriksson M, Bakardjiev A, Klein G, Lüscher B 1993 Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential. Oncogene 8:3199-3209
41. Diehl JA, Cheng M, Roussel MF, Sherr CJ 1998 Glycogen synthase kinase-3β regulates cyclin D 1 proteolysis and subcellular localization. Genes Dev 12:3499-3511
42. Wu RC, Feng Q, Lonard DM, O'Malley BW 2007 SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell 129:1125-1140
43. Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, Colditz GA 2001 Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst 93:1563-1568