The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

Oncotarget

Volumn 6, Issue 35, 2015, Pages 37930-37947

  Harada, Masako ^a   Benito, Juliana ^b   Yamamoto, Shinichi ^a   Kaur, Surinder ^c   Arslan, Dirim ^c   Ramirez, Santiago ^b   Jacamo, Rodrigo ^b   Platanias, Leonidas ^c   Matsushita, Hiromichi ^d   Fujimura, Tsutomu ^a,e   Kazuno, Saiko ^a   Kojima, Kensuke ^f   Tabe, Yoko ^a,b   Konopleva, Marina ^b  

^a JUNTENDO UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^f SAGA UNIVERSITY   (Japan)

Author keywords

Acute myeloid leukemia (AML); Heat shock factor (HSF); mTORC1 2 dual inhibitor; PIM inhibitor

Indexed keywords

AZD 1208; CYCLIN D1; HEAT SHOCK TRANSCRIPTION FACTOR 1; INITIATION FACTOR 4E BINDING PROTEIN 1; MESSENGER RNA; PROTEIN KINASE B; PROTEIN KINASE PIM 1; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VISTUSERTIB; AZD1208; BIPHENYL DERIVATIVE; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; MORPHOLINE DERIVATIVE; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; PROTEIN KINASE INHIBITOR; PROTO-ONCOGENE PROTEINS PIM; TARGET OF RAPAMYCIN KINASE; THIAZOLIDINE DERIVATIVE; TRANSCRIPTION FACTOR;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; DRUG TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; UPREGULATION; ANTAGONISTS AND INHIBITORS; COMBINATION DRUG THERAPY; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; LEUKEMIA, MYELOID, ACUTE; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

APOPTOSIS; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CELL PROLIFERATION; DNA-BINDING PROTEINS; DRUG THERAPY, COMBINATION; FLOW CYTOMETRY; HUMANS; LEUKEMIA, MYELOID, ACUTE; MORPHOLINES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THIAZOLIDINES; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 84947716438     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6122     Document Type: Article

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