메뉴 건너뛰기




Volumn 75, Issue 6, 2015, Pages 907-912

Heat shock factor 1 in protein homeostasis and oncogenic signal integration

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; HUR PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C THETA; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; PROTEIN; TRANSCRIPTION FACTOR;

EID: 84937512213     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-2905     Document Type: Review
Times cited : (36)

References (39)
  • 1
    • 84864585171 scopus 로고    scopus 로고
    • HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers
    • Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, et al. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 2012;150:549-62.
    • (2012) Cell , vol.150 , pp. 549-562
    • Mendillo, M.L.1    Santagata, S.2    Koeva, M.3    Bell, G.W.4    Hu, R.5    Tamimi, R.M.6
  • 2
    • 77953916528 scopus 로고    scopus 로고
    • HSP90 at the hub of protein homeostasis: Emerging mechanistic insights
    • Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 2010;11:515-28.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 515-528
    • Taipale, M.1    Jarosz, D.F.2    Lindquist, S.3
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and non-oncogene addiction
    • Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009;136:823-37.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 5
    • 33746364784 scopus 로고    scopus 로고
    • Structure and mechanism of the Hsp90 molecular chaperone machinery
    • Pearl LH, Prodromou C. Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu Rev Biochem 2006;75:271-94.
    • (2006) Annu Rev Biochem , vol.75 , pp. 271-294
    • Pearl, L.H.1    Prodromou, C.2
  • 6
    • 79960652801 scopus 로고    scopus 로고
    • Molecular chaperones in protein folding and proteostasis
    • Hartl FU, Bracher A, Hayer-Hartl M. Molecular chaperones in protein folding and proteostasis. Nature 2011;475:324-32.
    • (2011) Nature , vol.475 , pp. 324-332
    • Hartl, F.U.1    Bracher, A.2    Hayer-Hartl, M.3
  • 7
    • 0141484615 scopus 로고    scopus 로고
    • A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
    • Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003;425:407-10.
    • (2003) Nature , vol.425 , pp. 407-410
    • Kamal, A.1    Thao, L.2    Sensintaffar, J.3    Zhang, L.4    Boehm, M.F.5    Fritz, L.C.6
  • 8
    • 0032555685 scopus 로고    scopus 로고
    • Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1
    • Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 1998;94:471-80.
    • (1998) Cell , vol.94 , pp. 471-480
    • Zou, J.1    Guo, Y.2    Guettouche, T.3    Smith, D.F.4    Voellmy, R.5
  • 9
    • 34548416641 scopus 로고    scopus 로고
    • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
    • Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev 2007;21:2172-81.
    • (2007) Genes Dev , vol.21 , pp. 2172-2181
    • Boyault, C.1    Zhang, Y.2    Fritah, S.3    Caron, C.4    Gilquin, B.5    Kwon, S.H.6
  • 10
    • 21144444486 scopus 로고    scopus 로고
    • HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
    • Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 2005;18:601-7.
    • (2005) Mol Cell , vol.18 , pp. 601-607
    • Kovacs, J.J.1    Murphy, P.J.2    Gaillard, S.3    Zhao, X.4    Wu, J.T.5    Nicchitta, C.V.6
  • 11
    • 84857044092 scopus 로고    scopus 로고
    • Post-translational modifications of Hsp90 and their contributions to chaperone regulation
    • Mollapour M, Neckers L. Post-translational modifications of Hsp90 and their contributions to chaperone regulation. Biochim Biophys Acta 2012;1823:648-55.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 648-655
    • Mollapour, M.1    Neckers, L.2
  • 12
    • 67649217159 scopus 로고    scopus 로고
    • Inhibiting the transcription factor HSF1 as an anticancer strategy
    • Whitesell L, Lindquist S. Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets 2009;13:469-78.
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 469-478
    • Whitesell, L.1    Lindquist, S.2
  • 13
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • Neckers L, Workman P. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res 2012;18:64-76.
    • (2012) Clin Cancer Res , vol.18 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 14
    • 84858152476 scopus 로고    scopus 로고
    • SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells
    • Liu KS, Liu H, Qi JH, Liu QY, Liu Z, Xia M, et al. SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Lett 2012;318:180-8.
    • (2012) Cancer Lett , vol.318 , pp. 180-188
    • Liu, K.S.1    Liu, H.2    Qi, J.H.3    Liu, Q.Y.4    Liu, Z.5    Xia, M.6
  • 15
    • 34548658230 scopus 로고    scopus 로고
    • Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
    • Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007;130:1005-18.
    • (2007) Cell , vol.130 , pp. 1005-1018
    • Dai, C.1    Whitesell, L.2    Rogers, A.B.3    Lindquist, S.4
  • 16
    • 84867408640 scopus 로고    scopus 로고
    • Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis
    • Xi C, Hu Y, Buckhaults P, Moskophidis D, Mivechi NF. Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis. J Biol Chem 2012;287:35646-57.
    • (2012) J Biol Chem , vol.287 , pp. 35646-35657
    • Xi, C.1    Hu, Y.2    Buckhaults, P.3    Moskophidis, D.4    Mivechi, N.F.5
  • 17
    • 84891756044 scopus 로고    scopus 로고
    • HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer
    • Schulz R, Streller F, Scheel AH, Ruschoff J, Reinert MC, Dobbelstein M, et al. HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer. Cell Death Dis 2014;5:e980.
    • (2014) Cell Death Dis , vol.5 , pp. e980
    • Schulz, R.1    Streller, F.2    Scheel, A.H.3    Ruschoff, J.4    Reinert, M.C.5    Dobbelstein, M.6
  • 18
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 19
    • 84871750894 scopus 로고    scopus 로고
    • mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis
    • Chou SD, Prince T, Gong J, Calderwood SK. mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis. PLoS One 2012;7:e39679.
    • (2012) PLoS One , vol.7
    • Chou, S.D.1    Prince, T.2    Gong, J.3    Calderwood, S.K.4
  • 20
    • 84871523350 scopus 로고    scopus 로고
    • A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
    • Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, et al. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell 2012;151:1042-54.
    • (2012) Cell , vol.151 , pp. 1042-1054
    • Brandman, O.1    Stewart-Ornstein, J.2    Wong, D.3    Larson, A.4    Williams, C.C.5    Li, G.W.6
  • 21
    • 84871519128 scopus 로고    scopus 로고
    • Protein degradation: Ensuring quality at the ribosome
    • Wrighton KH. Protein degradation: ensuring quality at the ribosome. Nat Rev Mol Cell Biol 2013;14:1.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 1
    • Wrighton, K.H.1
  • 22
    • 84880438841 scopus 로고    scopus 로고
    • Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state
    • Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, et al. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science 2013;341:1238303.
    • (2013) Science , vol.341
    • Santagata, S.1    Mendillo, M.L.2    Tang, Y.C.3    Subramanian, A.4    Perley, C.C.5    Roche, S.P.6
  • 23
    • 84900425382 scopus 로고    scopus 로고
    • mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis
    • Acquaviva J, He S, Sang J, Smith DL, Sequeira M, Zhang C, et al. mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis. Mol Cancer Res 2014;12:703-13.
    • (2014) Mol Cancer Res , vol.12 , pp. 703-713
    • Acquaviva, J.1    He, S.2    Sang, J.3    Smith, D.L.4    Sequeira, M.5    Zhang, C.6
  • 24
    • 84873090446 scopus 로고    scopus 로고
    • The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma
    • Heimberger T, Andrulis M, Riedel S, Stuhmer T, Schraud H, Beilhack A, et al. The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma. Br J Haematol 2013;160:465-76.
    • (2013) Br J Haematol , vol.160 , pp. 465-476
    • Heimberger, T.1    Andrulis, M.2    Riedel, S.3    Stuhmer, T.4    Schraud, H.5    Beilhack, A.6
  • 25
    • 84865785716 scopus 로고    scopus 로고
    • HSP90 inhibitor 17-AAG selectively eradicates lymphoma stem cells
    • Newman B, Liu Y, Lee HF, Sun D, Wang Y. HSP90 inhibitor 17-AAG selectively eradicates lymphoma stem cells. Cancer Res 2012;72:4551-61.
    • (2012) Cancer Res , vol.72 , pp. 4551-4561
    • Newman, B.1    Liu, Y.2    Lee, H.F.3    Sun, D.4    Wang, Y.5
  • 27
    • 79956017927 scopus 로고    scopus 로고
    • Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells
    • Li D, Marchenko ND, Schulz R, Fischer V, Velasco-Hernandez T, Talos F, et al. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res 2011;9:577-88.
    • (2011) Mol Cancer Res , vol.9 , pp. 577-588
    • Li, D.1    Marchenko, N.D.2    Schulz, R.3    Fischer, V.4    Velasco-Hernandez, T.5    Talos, F.6
  • 28
    • 84867152376 scopus 로고    scopus 로고
    • Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
    • Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, et al. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest 2012;122:3742-54.
    • (2012) J Clin Invest , vol.122 , pp. 3742-3754
    • Dai, C.1    Santagata, S.2    Tang, Z.3    Shi, J.4    Cao, J.5    Kwon, H.6
  • 29
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • Moasser MM. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 2007;26:6469-87.
    • (2007) Oncogene , vol.26 , pp. 6469-6487
    • Moasser, M.M.1
  • 30
    • 70350564782 scopus 로고    scopus 로고
    • Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
    • Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, et al. Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene 2009;28:3689-701.
    • (2009) Oncogene , vol.28 , pp. 3689-3701
    • Zhao, Y.H.1    Zhou, M.2    Liu, H.3    Ding, Y.4    Khong, H.T.5    Yu, D.6
  • 31
    • 77956929098 scopus 로고    scopus 로고
    • Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    • Meng L, Gabai VL, Sherman MY. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene 2010;29:5204-13.
    • (2010) Oncogene , vol.29 , pp. 5204-5213
    • Meng, L.1    Gabai, V.L.2    Sherman, M.Y.3
  • 32
    • 84901020936 scopus 로고    scopus 로고
    • A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress
    • Li D, Yallowitz A, Ozog L, Marchenko N. A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress. Cell Death Dis 2014;5:e1194.
    • (2014) Cell Death Dis , vol.5 , pp. e1194
    • Li, D.1    Yallowitz, A.2    Ozog, L.3    Marchenko, N.4
  • 33
  • 34
    • 84904122732 scopus 로고    scopus 로고
    • High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors
    • Engerud H, Tangen IL, Berg A, Kusonmano K, Halle MK, Oyan AM, et al. High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors. Br J Cancer 2014;111:78-84.
    • (2014) Br J Cancer , vol.111 , pp. 78-84
    • Engerud, H.1    Tangen, I.L.2    Berg, A.3    Kusonmano, K.4    Halle, M.K.5    Oyan, A.M.6
  • 35
    • 84873741724 scopus 로고    scopus 로고
    • Englerin A stimulates PKCtheta to inhibit insulin signaling and to simultaneously activate HSF1: Pharmacologically induced synthetic lethality
    • Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee MJ, et al. Englerin A stimulates PKCtheta to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Cancer Cell 2013;23:228-37.
    • (2013) Cancer Cell , vol.23 , pp. 228-237
    • Sourbier, C.1    Scroggins, B.T.2    Ratnayake, R.3    Prince, T.L.4    Lee, S.5    Lee, M.J.6
  • 36
    • 84857169594 scopus 로고    scopus 로고
    • Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
    • Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol 2012;32:929-40.
    • (2012) Mol Cell Biol , vol.32 , pp. 929-940
    • Gabai, V.L.1    Meng, L.2    Kim, G.3    Mills, T.A.4    Benjamin, I.J.5    Sherman, M.Y.6
  • 37
    • 84932607499 scopus 로고    scopus 로고
    • HSF1 regulation of beta-catenin in mammary cancer cells through control of HuR/elavL1 expression
    • Jun 23. [Epub ahead of print]
    • Chou SD, Murshid A, Eguchi T, Gong J, Calderwood SK. HSF1 regulation of beta-catenin in mammary cancer cells through control of HuR/elavL1 expression. Oncogene 2014 Jun 23. [Epub ahead of print].
    • (2014) Oncogene
    • Chou, S.D.1    Murshid, A.2    Eguchi, T.3    Gong, J.4    Calderwood, S.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.