Inhibition of fatty-acid synthase suppresses p-akt and induces apoptosis in bladder cancer

Urology

Volumn 80, Issue 2, 2012, Pages 484.e9-484.e15

  Jiang, Bo ^a   Li, En Hui ^a   Lu, You Yi ^a   Jiang, Qi ^a   Cui, Di ^a   Jing, Yi Feng ^a   Xia, Shu Jie ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CERULENIN; CYCLIN D1; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA;

AGED; APOPTOSIS; ARTICLE; BLADDER CARCINOMA; CANCER CELL CULTURE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER RECURRENCE; CANCER TISSUE; CELL ASSAY; CELL LEVEL; CONTROLLED STUDY; DOWN REGULATION; ENZYME INACTIVATION; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSITIONAL CELL CARCINOMA; WESTERN BLOTTING;

EID: 84864613558     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2012.02.046     Document Type: Article

References (30)

1. F. Bray, R. Sankila, J. Ferlay Estimates of cancer incidence and mortality in Europe in 1995 Eur J Cancer 38 2002 99 166
2. F.P. Kuhajda, K. Jenner, F.D. Wood Fatty acid synthesis: a potential selective target for antineoplastic therapy Proc Natl Acad Sci U S A 91 1994 6379 6383
3. F.P. Kuhajda Fatty acid synthase and cancer: new application of an old pathway Cancer Res 66 2006 5977 5980
4. M. Mansour, D. Schwartz, R. Judd Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer Int J Oncol 38 2011 537 546
5. S. Uddin, A.K. Siraj, M. Al-Rasheed Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers J Clin Endocrinol Metab 93 2008 4088 4097
6. Y. Okawa, T. Hideshima, H. Ikeda Fatty acid synthase is a novel therapeutic target in multiple myeloma Br J Haematol 141 2008 659 671
7. P.L. Nguyen, J. Ma, J.E. Chavarro Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival J Clin Oncol 28 2010 3958 3964
8. P. Visca, V. Sebastiani, E.S. Pizer Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma Anticancer Res 23 2003 335 339
9. J.I. Epstein, M.B. Amin, V.R. Reuter The World Health Organization/international society of Urological pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder Bladder Consensus Conference committee Am J Surg Pathol 22 1998 1435 1448
10. G. Cheng, L. Xie Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro Molecules 16 2011 6758 6768
11. H. Gille, J. Downward Multiple ras effector pathways contribute to G(1) cell cycle progression J Biol Chem 274 1999 22033 22040
12. R. Vartanian, J. Masri, J. Martin AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/itch-mediated JUNB degradation Mol Cancer Res 9 2011 115 130
13. T. Migita, S. Ruiz, A. Fornari Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer J Natl Cancer Inst 101 2009 519 532
14. J.A. Menendez, L. Vellon, I. Mehmi Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells Proc Natl Acad Sci U S A 101 2004 10715 10720
15. S. Murata, K. Yanagisawa, K. Fukunaga Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice Cancer Sci 101 2010 1861 1865
16. L. Zeng, K.M. Biernacka, J.M. Holly Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase Endocr Relat Cancer 17 2010 539 551
17. A. Vazquez-Martin, J.M. Fernandez-Real, C. Oliveras-Ferraros Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients Int J Oncol 35 2009 1369 1376
18. K. Walter, S.M. Hong, S. Nyhan Serum fatty acid synthase as a marker of pancreatic neoplasia Cancer Epidemiol Biomarkers Prev 18 2009 2380 2385
19. K. Kim, H.Y. Kim, H.K. Cho The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element-binding protein-1 activation in cancer cells Carcinogenesis 31 2010 679 686
20. D. Wu, J. Tao, B. Xu Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells Urol Int 87 2011 105 113
21. A. Szanto, Z. Bognar, A. Szigeti Critical role of bad phosphorylation by Akt in cytostatic resistance of human bladder cancer cells Anticancer Res 29 2009 159 164
22. A. Belkhiri, A.A. Dar, A. Zaika t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism Cancer Res 68 2008 395 403
23. K. Kuroda, A. Horiguchi, M. Sumitomo Activated Akt prevents antitumor activity of gefitinib in renal cancer cells Urology 74 2009 209 215
24. J.A. Menendez, L. Vellon, R. Lupu Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells Med Hypotheses 64 2005 997 1001
25. J.V. Swinnen, P.P. Van Veldhoven, L. Timmermans Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains Biochem Biophys Res Commun 302 2003 898 903
26. E. De Schrijver, K. Brusselmans, W. Heyns RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells Cancer Res 63 2003 3799 3804
27. K.G. Zecchin, F.A. Rossato, H.F. Raposo Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis Lab Invest 91 2011 232 240
28. D.L. Vaux, S. Cory, J.M. Adams Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells Nature 335 1988 440 442
29. R.J. Youle, A. Strasser The BCL-2 protein family: opposing activities that mediate cell death Nat Rev Mol Cell Biol 9 2008 47 59
30. M.S. Ola, M. Nawaz, H. Ahsan Role of Bcl-2 family proteins and caspases in the regulation of apoptosis Mol Cell Biochem 351 2011 41 58