Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 253, Issue 12, 2015, Pages 2309-2315

  Zheng, Xiao Yu ^a   Li, Lin Jie ^a   Li, Wei ^a   Jiang, Pei Fang ^a   Shen, Hong Qiang ^a   Chen, Ying Hu ^a   Chen, Xi ^a  

^a CHILDREN S HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

3 methyladenine; Apoptosis; Autophagy; Chloroquine; Retinoblastoma; Vincristine

Indexed keywords

3 METHYLADENINE; CASPASE 3; CHLOROQUINE; PROTEIN; PROTEIN KINASE B; PROTEIN LC3 II; PROTEIN P62; UNCLASSIFIED DRUG; VINCRISTINE; 3-METHYLADENINE; ADENINE; ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; CHOLECYSTOKININ OCTAPEPTIDE; ENZYME INHIBITOR; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; P62 PROTEIN, HUMAN; RNA BINDING PROTEIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL VIABILITY; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; RETINOBLASTOMA; RETINOBLASTOMA CELL LINE; TUMOR CELL; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL CYCLE CHECKPOINT; CELL SURVIVAL; COMBINATION DRUG THERAPY; DRUG EFFECTS; HUMAN; METABOLISM; PATHOLOGY; RETINA TUMOR; TUMOR CELL CULTURE;

ADENINE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIRHEUMATIC AGENTS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL SURVIVAL; CHLOROQUINE; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; RETINAL NEOPLASMS; RETINOBLASTOMA; RNA-BINDING PROTEINS; SINCALIDE; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 84947619031     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-015-3157-1     Document Type: Article

References (29)

1. Dimaras H, Kimani K, Dimba EA, Gronsdahl P, White A, Chan HS, Gallie BL (2012) Retinoblastoma. Lancet 379:1436–1446. doi:10.1016/S0140-6736(11)61137-9
2. Park SJ, Woo SJ, Park KH (2014) Incidence of retinoblastoma and survival rate of retinoblastoma patients in Korea using the Korean National Cancer Registry database (1993–2010). Invest Ophthalmol Vis Sci 55:2816–2821. doi:10.1167/iovs.14-14078
3. Gunduz K, Gunalp I, Yalcindag N, Unal E, Tacyildiz N, Erden E, Geyik PO (2004) Causes of chemoreduction failure in retinoblastoma and analysis of associated factors leading to eventual treatment with external beam radiotherapy and enucleation. Ophthalmology 111:1917–1924
4. Murphree AL, Villablanca JG, Deegan WF 3rd, Sato JK, Malogolowkin M, Fisher A, Parker R, Reed E, Gomer CJ (1996) Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch Ophthalmol 114:1348–1356
5. Song X, Wang H, Jia R, Cun B, Zhao X, Zhou Y, Xu X, Qian G, Ge S, Fan X (2012) Combined treatment with an oncolytic adenovirus and antitumor activity of vincristine against retinoblastoma cells. Int J Mol Sci 13:10736–10749. doi:10.3390/ijms130910736
6. Mitra M, Kandalam M, Sundaram CS, Verma RS, Maheswari UK, Swaminathan S, Krishnakumar S (2011) Reversal of stathmin-mediated microtubule destabilization sensitizes retinoblastoma cells to a low dose of antimicrotubule agents: a novel synergistic therapeutic intervention. Invest Ophthalmol Vis Sci 52:5441–5448. doi:10.1167/iovs.10-6973
7. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741–752
8. Xu H, Wang C, Zhu H, Liu S, Xu X, Jiang Y (1995) Characteristics of an established retinoblastoma cell line HXO-Rb44. Yan Ke Xue Bao 11:16–21
9. She JJ, Zhang PG, Che XM, Wang X, Wang ZM (2011) Side population cells from HXO-Rb44 retinoblastoma cell line have cancer-initiating property. Int J Ophthalmol 4:461–465. doi:10.3980/j.issn.2222-3959.2011.05.01
10. Cai JY, Tang JY, Pan C, Xu M, Xue HL, Zhou M, Dong L, Ye QD, Jiang H, Shen SH, Chen J (2010) Results of RS-99 protocol for childhood solid tumors. World J Pediatr 6:43–49
11. Groth-Pedersen L, Ostenfeld MS, Hoyer-Hansen M, Nylandsted J, Jaattela M (2007) Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine. Cancer Res 67:2217–2225
12. Zhan Z, Li Q, Wu P, Ye Y, Tseng HY, Zhang L, Zhang XD (2012) Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1. Autophagy 8:109–121. doi:10.4161/auto.8.1.18319
13. White E (2012) Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 12:401–410. doi:10.1038/nrc3262
14. Bruinink A, Zimmermann G, Riesen F (1991) Neurotoxic effects of chloroquine in vitro. Arch Toxicol 65:480–484
15. Maenpaa H, Toimela T, Mannerstrom M, Saransaari P, Tahti H (2004) Toxicity of selected cationic drugs in retinoblastomal cultures and in cocultures of retinoblastomal and retinal pigment epithelial cell lines. Neurochem Res 29:305–311
16. Browning DJ (2002) Hydroxychloroquine and chloroquine retinopathy: screening for drug toxicity. Am J Ophthalmol 133:649–656
17. Toimela T, Salminen L, Tahti H (1998) Effects of tamoxifen, toremifene and chloroquine on the lysosomal enzymes in cultured retinal pigment epithelial cells. Pharmacol Toxicol 83:246–251
18. Toimela T, Tahti H, Salminen L (1995) Retinal pigment epithelium cell culture as a model for evaluation of the toxicity of tamoxifen and chloroquine. Ophthalmic Res 27(Suppl 1):150–153
19. Sridevi P, Nhiayi MK, Setten RL, Wang JY (2013) Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine. PLoS One 8:e77495. doi:10.1371/journal.pone.0077495
20. Yoon YH, Cho KS, Hwang JJ, Lee SJ, Choi JA, Koh JY (2010) Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells. Invest Ophthalmol Vis Sci 51:6030–6037. doi:10.1167/iovs.10-5278
21. Liu F, Shang Y, Chen SZ (2014) Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro. Acta Pharmacol Sin 35:645–652. doi:10.1038/aps.2014.3
22. Firat E, Weyerbrock A, Gaedicke S, Grosu AL, Niedermann G (2012) Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote gamma-irradiation-induced cell death in primary stem-like glioma cells. PLoS One 7:e47357. doi:10.1371/journal.pone.0047357
23. Li M, Khambu B, Zhang H, Kang JH, Chen X, Chen D, Vollmer L, Liu PQ, Vogt A, Yin XM Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity. J Biol Chem 288:35769–35780
24. Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM (2010) Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285:10850–10861. doi:10.1074/jbc.M109.080796
25. Sheng Y, Sun B, Guo WT, Zhang YH, Liu X, Xing Y, Dong DL (2013) 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Biochem Biophys Res Commun 432:5–9. doi:10.1016/j.bbrc.2013.01.106
26. McFarland AJ, Anoopkumar-Dukie S, Perkins AV, Davey AK, Grant GD (2012) Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity. Arch Toxicol 86:275–284. doi:10.1007/s00204-011-0755-5
27. Cheng X, Liu H, Jiang CC, Fang L, Chen C, Zhang XD, Jiang ZW (2014) Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells. Int J Mol Med 34:772–781. doi:10.3892/ijmm.2014.1822
28. Ito S, Koshikawa N, Mochizuki S, Takenaga K (2007) 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition. Int J Oncol 31:261–268
29. Hou H, Zhang Y, Huang Y, Yi Q, Lv L, Zhang T, Chen D, Hao Q, Shi Q (2012) Inhibitors of phosphatidylinositol 3′-kinases promote mitotic cell death in HeLa cells. PLoS One 7:e35665. doi:10.1371/journal.pone.0035665