Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Li, Liwei ^a   Gao, Fei ^a,b   Jiang, Yifeng ^a,b   Yu, Lingxue ^a   Zhou, Yanjun ^a   Zheng, Hao ^a   Tong, Wu ^a   Yang, Shen ^a   Xia, Tianqi ^a   Qu, Zehui ^a   Tong, Guangzhi ^a,b  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b YANGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5' UNTRANSLATED REGION; ALPHA INTERFERON; ANTIVIRUS AGENT; MESSENGER RNA; MICRORNA; TUMOR NECROSIS FACTOR;

5' UNTRANSLATED REGION; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GENOME; GROWTH, DEVELOPMENT AND AGING; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PIG; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; VIRUS REPLICATION;

5' UNTRANSLATED REGIONS; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIVIRAL AGENTS; BASE SEQUENCE; GENE EXPRESSION REGULATION; GENOME; INTERFERON-ALPHA; MICRORNAS; MOLECULAR SEQUENCE DATA; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; RNA, MESSENGER; SUS SCROFA; TUMOR NECROSIS FACTOR-ALPHA; VIRUS REPLICATION;

EID: 84947586215     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17010     Document Type: Article

References (44)

1. Rossow, K. D. Porcine reproductive and respiratory syndrome. Vet Pathol 35, 1-20 (1998).
2. Chand, R. J., Trible, B. R., Rowland, R. R. Pathogenesis of porcine reproductive and respiratory syndrome virus. Curr Opin Virol 2, 256-263 (2012).
3. Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
4. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
5. Gottwein, E., Cullen, B. R. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 3, 375-387 (2008).
6. Lecellier, C. H. et al. A cellular microRNA mediates antiviral defense in human cells. Science 308, 557-560 (2005).
7. Triboulet, R. et al. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science 315, 1579-1582 (2007).
8. Zhuo, Y., Gao, G., Shi, J. A., Zhou, X., Wang, X. miRNAs: biogenesis, origin and evolution, functions on virus-host interaction. Cell Physiol Biochem 32, 499-510 (2013).
9. Nathans, R. et al. Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell 34, 696-709 (2009).
10. Otsuka, M. et al. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity 27, 123-134 (2007).
11. Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M., Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liverspecific MicroRNA. Science 309, 1577-1581 (2005).
12. Jopling, C. L. Targeting microRNA-122 to Treat Hepatitis C Virus Infection. Viruses 2, 1382-1393 (2010).
13. Ma, Y. J. et al. Cellular microRNA let-7c inhibits M1 protein expression of the H1N1 influenza A virus in infected human lung epithelial cells. J Cell Mol Med 16, 2539-2546 (2012).
14. Forsberg, R. Divergence time of porcine reproductive and respiratory syndrome virus subtypes. Mol Biol Evol 22, 2131-2134 (2005).
15. Hanada, K., Suzuki, Y., Nakane, T., Hirose, O., Gojobori, T. The origin and evolution of porcine reproductive and respiratory syndrome viruses. Mol Biol Evol 22, 1024-1031 (2005).
16. Lu, J. et al. A 5-proximal stem-loop structure of 5 untranslated region of porcine reproductive and respiratory syndrome virus genome is key for virus replication. Virol J 8, 172 (2011).
17. Gao, F. et al. Replacement of the heterologous 5 untranslated region allows preservation of the fully functional activities of type 2 porcine reproductive and respiratory syndrome virus. Virology 439, 1-12 (2013).
18. Wang, D. et al. MiR-125b reduces porcine reproductive and respiratory syndrome virus replication by negatively regulating the NF-kappaB pathway. PLoS One 8, e55838 (2013).
19. Zhang, Q. et al. MicroRNA-23 inhibits PRRSV replication by directly targeting PRRSV RNA and possibly by upregulating type I interferons. Virology 450-451, 182-195 (2014).
20. Wu, J. et al. MiR-506 inhibits PRRSV replication in MARC-145 cells via CD151. Mol Cell Biochem 394, 275-281 (2014).
21. Guo, X. K. et al. Increasing expression of microRNA 181 inhibits porcine reproductive and respiratory syndrome virus replication and has implications for controlling virus infection. J Virol 87, 1159-1171 (2013).
22. Gao, L. et al. MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163. J Virol 87, 8808-8812 (2013).
23. Li, L. et al. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Res 195, 86-94 (2015).
24. Jia, X. et al. Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity. Sci Rep 5, 10651 (2015).
25. Hsu, P. W., Lin, L. Z., Hsu, S. D., Hsu, J. B., Huang, H. D. ViTa: prediction of host microRNAs targets on viruses. Nucleic Acids Res 35, D381-385 (2007).
26. tenOever, B. R. RNA viruses and the host microRNA machinery. Nat Rev Microbiol 11, 169-180 (2013).
27. Griffiths-Jones, S., Saini, H. K., van Dongen, S., Enright, A. J. miRBase: tools for microRNA genomics. Nucleic Acids Res 36, D154-158 (2008).
28. Zhang, J. et al. NF-kappaB-modulated miR-130a targets TNF-alpha in cervical cancer cells. J Transl Med 12, 155 (2014).
29. Li, S. et al. MicroRNA-130a inhibits HCV replication by restoring the innate immune response. J Viral Hepat 21, 121-128 (2014).
30. Tong, G. Z. et al. Highly pathogenic porcine reproductive and respiratory syndrome, China. Emerg Infect Dis 13, 1434-1436 (2007).
31. Costa Mdo, C. et al. Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease. Mol Ther 21, 1898-1908 (2013).
32. Zhou, Y. J. et al. Highly virulent porcine reproductive and respiratory syndrome virus emerged in China. Transbound Emerg Dis 55, 152-164 (2008).
33. Bitko, V., Musiyenko, A., Shulyayeva, O., Barik, S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 11, 50-55 (2005).
34. Zhang, W. et al. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nat Med 11, 56-62 (2005).
35. Palliser, D. et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439, 89-94 (2006).
36. Gao, F. et al. Cis-acting structural element in 5 UTR is essential for infectivity of porcine reproductive and respiratory syndrome virus. Virus Res 163, 108-119 (2012).
37. Yuan, S., Wei, Z. Construction of infectious cDNA clones of PRRSV: separation of coding regions for nonstructural and structural proteins. Sci China C Life Sci 51, 271-279 (2008).
38. Wensvoort, G. et al. Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet Q 13, 121-130 (1991).
39. Lv, J., Zhang, J., Sun, Z., Liu, W., Yuan, S. An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome. J Gen Virol 89, 2075-2079 (2008).
40. Wang, X. et al. Development of a differentiable virus via a spontaneous deletion in the nsp2 region associated with cell adaptation of porcine reproductive and respiratory syndrome virus. Virus Res 171, 150-160 (2013).
41. Tian, D., Zheng, H., Zhang, R., Zhuang, J., Yuan, S. Chimeric porcine reproductive and respiratory syndrome viruses reveal full function of genotype 1 envelope proteins in the backbone of genotype 2. Virology 412, 1-8 (2011).
42. Clewley, J. P., Arnold, C. MEGALIGN. The multiple alignment module of LASERGENE. Methods Mol Biol 70, 119-129 (1997).
43. Reed, L. J., Muench, H. A simple method of estimating fifty percent endpoints. The American Journal of Hygien 27, 493-497 (1938).
44. Bookout, A. L., Cummins, C. L., Mangelsdorf, D. J., Pesola, J. M., Kramer, M. F. High-throughput real-time quantitative reverse transcription PCR. Curr Protoc Mol Biol 73, 15.18.11-15.18.28 (2006).