Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Jia, Xiaojuan ^a,b   Bi, Yuhai ^b   Li, Jing ^b   Xie, Qing ^d   Yang, Hanchun ^a   Liu, Wenjun ^b,c  

^a China Agricultural University   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; MICRORNA; VIRUS RNA;

ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PATHOLOGY; PHYSIOLOGY; PIG; PLASMID; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; VIROLOGY; VIRUS REPLICATION;

ANIMALS; CELL LINE; GENES, REPORTER; HOST-PATHOGEN INTERACTIONS; IMMUNITY, INNATE; INTERFERON TYPE I; MICRORNAS; PLASMIDS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, VIRAL; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SWINE; UP-REGULATION; VIRUS REPLICATION;

EID: 84930226476     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep10651     Document Type: Article

References (42)

1. Han, M. & Yoo, D. Engineering the PRRS virus genome: Updates and perspectives. Vet Microbiol 174, 279-295 (2014).
2. Johnson, C. R., Griggs, T. F., Gnanandarajah, J. & Murtaugh, M. P. Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses. J Gen Virol 92, 1107-1116 (2011).
3. Fang, Y. & Snijder, E. J. The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins. Virus Res 154, 61-76 (2010).
4. Tian, K. et al. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS ONE 2, e526 (2007).
5. Zhou, Z. et al. The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009. Vet Microbiol 150, 257-269 (2011).
6. Hiddingh, L. et al. Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis. Sci Rep 4, 5260 (2014).
7. Guo, Z. et al. Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues. Sci Rep 4, 5150 (2014).
8. Guo, X. K. et al. Increasing Expression of MicroRNA 181 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication and Has Implications for Controlling Virus Infection. J Virol 87, 1159-1171 (2013).
9. Song, L., Liu, H., Gao, S., Jiang, W. & Huang, W. Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol 84, 8849-8860 (2010).
10. Zhang, G.L. et al. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res 88, 169-175 (2010).
11. Huang, J. et al. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med 13, 1241-1247 (2007).
12. Liu, H., Song, L. & Huang, W. [MiR26a and miR939 regulate the replication of H1N1 influenza virus in MDCK cell]. Wei Sheng Wu Xue Bao 50, 1399-1405 (2010).
13. Triboulet, R. et al. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science 315, 1579-1582 (2007).
14. Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M. & Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liverspecific MicroRNA. Science 309, 1577-1581 (2005).
15. Wang, S. et al. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. Hepatology 55, 730-741 (2012).
16. Witwer, K. W., Sisk, J. M., Gama, L. & Clements, J. E. MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response. J Immunol 184, 2369-2376 (2010).
17. Overend, C. et al. Recombinant swine beta interferon protects swine alveolar macrophages and MARC-145 cells from infection with Porcine reproductive and respiratory syndrome virus. J Gen Virol 88, 925-931 (2007).
18. O'Connell, R. M., Rao, D. S., Chaudhuri, A. A. & Baltimore, D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 10, 111-122 (2010).
19. Zhang, B. et al. Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis 32, 2-9 (2011).
20. Kota, J. et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137, 1005-1017 (2009).
21. Salvatori, B. et al. Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2. Genes Cancer 2, 585-592 (2011).
22. Lu, J. et al. MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res 71, 225-233 (2011).
23. Caputo, V. et al. Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allelespecific binding. PLoS One 6, e28656 (2011).
24. Huse, J. T. et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev 23, 1327-1337 (2009).
25. Sander, S. et al. MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 112, 4202-4212 (2008).
26. Luzi, E. et al. Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor. J Bone Miner Res 23, 287-295 (2008).
27. Li, L. et al. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Res 195, 86-94 (2015).
28. Schoggins, J. W. & Rice, C. M. Interferon-stimulated genes and their antiviral effector functions. Curr Opin Virol 1, 519-525 (2011).
29. Luo, R. et al. Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus (PRRSV). Antiviral Res 91, 99-101 (2011).
30. Wei, Z. Y. et al. Inhibitory effects of indigowoad root polysaccharides on porcine reproductive and respiratory syndrome virus replication in vitro. Antivir Ther 16, 357-363 (2011).
31. Li, G. et al. Effective suppression of replication of porcine reproductive and respiratory syndrome virus by adenovirus-mediated small interfering RNAs targeting ORF1b, 5 and 7 genes. J Virol Methods 157, 40-46 (2009).
32. Li, G. et al. Inhibition of porcine reproductive and respiratory syndrome virus replication by adenovirus-mediated RNA interference both in porcine alveolar macrophages and swine. Antiviral Res 82, 157-165 (2009).
33. He, Y. X., Hua, R. H., Zhou, Y. J., Qiu, H. J. & Tong, G. Z. Interference of porcine reproductive and respiratory syndrome virus replication on MARC-145 cells using DNA-based short interfering RNAs. Antiviral Res 74, 83-91 (2007).
34. Huang, J. et al. Inhibition of porcine reproductive and respiratory syndrome virus replication by short hairpin RNA in MARC- 145 cells. Vet Microbiol 115, 302-310 (2006).
35. Yang, M. et al. RNA interference targeting nucleocapsid protein inhibits porcine reproductive and respiratory syndrome virus replication in Marc-145 cells. J Microbiol 52, 333-339 (2014).
36. Xiao, S. et al. Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs. Virol J 8, 491 (2011).
37. Christopher-Hennings, J. et al. Persistence of porcine reproductive and respiratory syndrome virus in serum and semen of adult boars. J Vet Diagn Invest 7, 456-464 (1995).
38. Neumann, G. et al. Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A 96, 9345-9350 (1999).
39. Bi, Y. et al. Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice. Virol J 8, 505 (2011).
40. Hou, J. et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 183, 2150-2158 (2009).
41. Li, Y., Zhao, L., Wang, S., Xing, J. & Zheng, C. Identification of a novel NLS of herpes simplex virus type 1 (HSV-1) VP19C and its nuclear localization is required for efficient production of HSV-1. J Gen Virol 93, 1869-1875 (2012).
42. Reed, L. J. & Muench, H. A simple method of estimating fifty percent endpoints. The American Journal of Hygiene. 27, 493-497. (1938).