Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling

Cardiovascular Research

Volumn 108, Issue 2, 2015, Pages 243-253

  Ndongson Dongmo, Bernadin ^a   Heller, Regine ^a   Hoyer, Dirk ^a   Brodhun, Michael ^b   Bauer, Michael ^a   Winning, Johannes ^a   Hirsch, Emilio ^c   Wetzker, Reinhard ^a   Schlattmann, Peter ^a   Bauer, Reinhard ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b HELIOS KLINIKUM ERFURT   (Germany)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Acute inflammation; Autonomic nervous system; iNOS; Myocardial contractility; NFAT; Phosphoinositide 3 kinase

Indexed keywords

CATECHOLAMINE; CYCLIC AMP; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPID; NORADRENALIN; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; TRANSCRIPTION FACTOR NFAT; CALCIUM; NOS2 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CG PROTEIN, MOUSE;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CATALYSIS; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; GENE LOSS; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; INFLAMMATION; MOUSE; MYOCARDIAL DEPRESSION; MYOCARDIAL DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SURVIVAL RATE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WILD TYPE; ANIMAL; AUTONOMIC NERVOUS SYSTEM; C57BL MOUSE; CARDIOMYOPATHIES; CELL CULTURE; COMPLICATION; ENZYMOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; SEPSIS;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; CALCIUM; CARDIOMYOPATHIES; CELLS, CULTURED; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; CYCLIC AMP; MICE, INBRED C57BL; MICE, KNOCKOUT; NFATC TRANSCRIPTION FACTORS; NITRIC OXIDE SYNTHASE TYPE II; SEPSIS; VENTRICULAR FUNCTION, LEFT;

EID: 84947580386     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv217     Document Type: Article

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