Beta-block the septic heart

Critical Care Medicine

Volumn 38, Issue 10 SUPPL., 2010, Pages

  Rudiger, Alain ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Adrenergic blockade; Cardiomyopathy; Esmolol; Heart failure; Metoprolol; Multiple organ failure; Sepsis; Shock; blocker

Indexed keywords

ESMOLOL; LANDIOLOL; METOPROLOL; MILRINONE; NORADRENALIN; PROPRANOLOL;

ADRENERGIC STIMULATION; CELL DEATH; CONFERENCE PAPER; CONTINUOUS INFUSION; DATA BASE; DRUG HALF LIFE; ENERGY EXPENDITURE; HEART FUNCTION; HEART PROTECTION; HEART RATE; HEART STIMULATION; HEART STROKE VOLUME; HUMAN; IN VIVO STUDY; LUNG INJURY; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK;

EID: 78650413745     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181f204ca     Document Type: Conference Paper

References (63)

1. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-150
2. Rudiger A, Stotz M, Singer M: Cellular processes in sepsis. Swiss Med Wkly 2008;138:629-634
3. Vieillard-Baron A, Caille V, Charron C, et al: Actual incidence of global left ventricular hypokinesia in adult septic shock. Crit Care Med 2008;36:1701-1706
4. Annane D, Trabold F, Sharshar T, et al: Inappropriate sympathetic activation at onset of septic shock: A spectral analysis approach. Am J Respir Crit Care Med 1999;160:458-465
5. Kovarik MF, Jones SB, Romano FD: Plasma catecholamines following cecal ligation and puncture in the rat. Circ Shock 1987;22:281-290
6. Boldt J, Menges T, Kuhn D, et al: Alterations in circulating vasoactive substances in the critically ill-A comparison between survivors and non-survivors. Intensive Care Med 1995;21:218-225
7. Zhou M, Das P, Simms HH, et al: Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10. Biochim Biophys Acta 2005;1740:446-452
8. Bergquist J, Tarkowski A, Ekman R, et al: Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. Proc Natl Acad Sci U S A 1994;91:12912-12916
9. Musso NR, Brenci S, Setti M, et al: Catecholamine content and in vitro catecholamine synthesis in peripheral human lymphocytes. J Clin Endocrinol Metab 1996;81:3553-3557
10. Marino F, Cosentino M, Bombelli R, et al: Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells. Exp Hematol 1999;27:489-495
11. Flierl MA, Rittirsch D, Nadeau BA, et al: Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 2007;449:721-725
12. Cosentino M, Marino F, Bombelli R, et al: Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils. Life Sci 1999;64:975-981
13. Jones AE, Craddock PA, Tayal VS, et al: Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension. Shock 2005;24:513-517
14. Azimi G, Vincent J-L: Ultimate survival from septic shock. Resuscitation 1986;14:245-253
15. Brealey D, Brand M, Hargreaves I, et al: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002;360:219-223
16. Turner A, Tsamitros M, Bellomo R: Myocardial cell injury in septic shock. Crit Care Med 1999;27:1775-1780
17. Ammann P, Fehr T, Minder EI, et al: Elevation of troponin I in sepsis and septic shock. Intensive Care Med 2001;27:965-969
18. Rudiger A, Singer M: Mechanisms of sepsisinduced cardiac dysfunction. Crit Care Med 2007;35:1599-1608
19. Tang C, Liu M-S: Internal externalization followed by internalization of β-adrenergic receptors in rat heart during sepsis. Am J Physiol Regul Integr Comp Physiol 1996;270:254-263
20. Tang C, Yang J, Wu LL, et al: Phosphorylation of beta-adrenergic receptor leads to its redistribution in rat heart during sepsis. Am J Physiol 1998;274:R1078-R1086
21. Böhm M, Kirchmayr R, Gierschik P, et al: Increase of myocardial inhibitory G-proteins in catecholamine-refractory septic shock or in septic multiorgan failure. Am J Med 1995;98:183-186
22. Bernardin G, Strosberg AD, Bernard A, et al: β-adrenergic receptor-dependent and-independent stimulation of adenylate cyclase is impaired during severe sepsis in humans. Intensive Care Med 1998;24:1315-1322
23. Wu L-L, Yang S-L, Yang R-C, et al: G protein and adenylate cyclase complex-mediated signal transduction in the rat heart during sepsis. Shock 2003;19:533-537
24. Matsuda N, Hattori Y, Akaishi Y, et al: Impairment of cardiac β-adrenoceptor cellular signaling by decreased expression of Gsα in septic rabbits. Anesthesiology 2000;93:1465-1473
25. Gulick TS, Chung MK, Pieper SJ, et al: Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness. Proc Natl Acad Sci USA 1989;86:6753-6757
26. Chung MK, Gulick TS, Rotondo RE, et al: Mechanism of cytokine inhibition of betaadrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes Impairment of signal transduction. Circ Res 1990;67:753-763
27. Cariou A, Pinsky MR, Monchi M, et al: Is myocardial adrenergic responsiveness depressed in human septic shock? Intensive Care Med 2008;34:917-922
28. Sharshar T, Gray F, Lorin de la Grandmaison G, et al: Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003;362:1799-1805
29. Macarthur H, Westfall TC, Riley DP, et al: Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proc Natl Acad Sci U S A 2000;97:9753-9758
30. Parker MM, Shelhamer JH, Bacharach SL, et al: Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984;100:483-490
31. Singer M, Glynne P: Treating critical illness: The importance of first doing no harm. PLoS Med 2005;2:e167
32. Hayes MA, Timmins AC, Yau E, et al: Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994;330:1717-1722
33. Gattinoni L, Brazzi L, Pelosi P, et al: A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 1995;333:1025-1032
34. Dünser MW, Hasibeder WR: Sympathetic overstimulation during critical illness: Adverse effects of adrenergic stress. J Intensive Care Med 2009;24:293-316
35. Berk JL, Hagen JF, Beyer WH, et al: The treatment of endotoxin shock by beta adrenergic blockade. Ann Surg 1969;169:74-81
36. Schmitz D, Wilsenack K, Lendemanns S, et al: Beta-adrenergic blockade during systemic inflammation: Impact on cellular immune functions and survival in a murine model of sepsis. Resuscitation 2007;72:286-294
37. Patterson AJ, Zhu W, Chow A, et al: Protecting the myocardium: A role for the beta2 adrenergic receptor in the heart. Crit Care Med 2004;32:1041-1048
38. Suzuki T, Morisaki H, Serita R, et al: Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med 2005;33:2294-2301
39. Hagiwara S, Iwasaka H, Maeda H, et al: Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model. Shock 2009;31:515-520
40. Ackland GL, Yao ST, Rudiger A, et al: Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats. Crit Care Med 2010;38:388-394
41. Berk JL, Hagen JF, Dunn JM: The role of beta adrenergic blockade in the treatment of septic shock. Surg Gynecol Obstet 1970;130:1025-1034
42. Gore DC, Wolfe RR: Hemodynamic and metabolic effects of selective beta1 adrenergic blockade during sepsis. Surgery 2006;139:686-694
43. Schmittinger CA, Dünser MW, Haller M, et al: Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression. Crit Care 2008;12:R99
44. de Montmollin E, Aboab J, Mansart A, et al: Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Crit Care 2009;13:230
45. Norbury WB, Jeschke MG, Herndon DN: Metabolism modulators in sepsis: propranolol. Crit Care Med 2007;35:S616-S620
46. Novotny NM, Lahm T, Markel TA, et al: Betablockers in sepsis: Reexamining the evidence. Shock 2009;31:113-119
47. Wang J-F, Meissner A, Malek S, et al: Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis. Am J Physiol Heart Circ Physiol 2005;289:1577-1583
48. Lyon AR, Rees PS, Prasad S, et al: Stress (Takotsubo) cardiomyopathy-A novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med 2008;5:22-29
49. Wittstein IS, Thiemann DR, Lima JA, et al: Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005;352:539-548
50. Cruickshank JM, Neil-Dwyer G, Degaute JP, et al: Reduction of stress/catecholamineinduced cardiac necrosis by beta 1-selective blockade. Lancet 1987;2:585-589
51. Herndon DN, Hart DW, Wolf SE, et al: Reversal of catabolism by beta-blockade after severe burns. N Engl J Med 2001;345:1223-1229
52. Arbabi S, Ahrns KS, Wahl WL, et al: Betablocker use is associated with improved outcomes in adult burn patients. J Trauma 2004;56:265-271
53. Dellinger RP, Levy MM, Carlet JM, et al: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327
54. Jardin F, Vieillard-Baron A: Is there a safe plateau pressure in ARDS? The right heart only knows. Intensive Care Med 2007;33:444-447
55. Oldner A, Konrad D, Weitzberg E, et al: Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock. Crit Care Med 2001;29:2185-2193
56. Behrends M, Peters J: The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. Intensive Care Med 2003;29:1802-1807
57. Faivre V, Kaskos H, Callebert J, et al: Cardiac and renal effects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide- treated rabbits. Anesthesiology 2005;103:514-521
58. Morelli A, De Castro S, Teboul J-L, et al: Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 2005;31:638-644
59. De Ferrari GM, Mazzuero A, Agnesina L, et al: Favourable effects of heart rate reduction with intravenous administration of diaveridine in patients with advanced heart failure. Eur J Heart Fail 2008;10:550-555
60. Meybohm P, Gruenewald M, Albrecht M, et al: Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling. PloS One 2009;4:e7588
61. Solomon SB, Minneci PC, Deans KJ, et al: Effects of intra-aortic balloon counterpulsation in a model of septic shock. Crit Care Med 2009;37:7-18
62. Chopra V, Eagle KA: Perioperative betablockers for cardiac risk reduction: Time for clarity. JAMA 303:551-552
63. Fleischmann KE, Beckman JA, Buller CE, et al: 2009 ACCF/AHA focused update on perioperative beta blockade. J Am Coll Cardiol 2009;54:2102-2128