MicroRNAs' involvement in osteoarthritis and the prospects for treatments

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Yu, Xiao Ming ^a   Meng, Hao Ye ^a   Yuan, Xue Ling ^a   Wang, Yu ^a   Guo, Quan Yi ^a   Peng, Jiang ^a   Wang, Ai Yuan ^a   Lu, Shi Bi ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; COLLAGENASE 3; EXPORTIN 5; GROWTH DIFFERENTIATION FACTOR 5; HISTONE DEACETYLASE 5; MESSENGER RNA; MICRORNA; MICRORNA 125B; MICRORNA 146A; MICRORNA 155; MICRORNA 182; MICRORNA 210; MICRORNA 214; MICRORNA 22; MICRORNA 221; MICRORNA 222; MICRORNA 223; MICRORNA 26A; MICRORNA 29A; MICRORNA 29B; OSTEONECTIN; RNA POLYMERASE II; SMAD1 PROTEIN; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA;

AGING; ARTICULAR CARTILAGE; BONE DEVELOPMENT; CARTILAGE DEGENERATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CHONDROGENESIS; COLON POLYPOSIS; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HOMEOSTASIS; HUMAN; NONHUMAN; OSTEOARTHRITIS; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY;

EID: 84947474479     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/236179     Document Type: Review

References (109)

1. R. F. Loeser, S. R. Goldring, C. R. Scanzello, and M. B. Goldring, "Osteoarthritis: a disease of the joint as an organ," Arthritis & Rheumatism, vol. 64, no. 6, pp. 1697-1707, 2012.
2. D. B. Burr and M. A. Gallant, "Bone remodelling in osteoarthri-tis," Nature Reviews Rheumatology, vol. 8, no. 11, pp. 665-673, 2012.
3. S. Suri and D. A. Walsh, "Osteochondral alterations in osteoarthritis," Bone, vol. 51, no. 2, pp. 204-211, 2012.
4. J. Lu, G. Getz, E. A. Miska et al., "MicroRNA expression profles classify human cancers," Nature, vol. 435, no. 7043, pp. 834-838, 2005.
5. G. Marcucci, M. D. Radmacher, K. Maharry et al., "MicroRNA expression in cytogenetically normal acute myeloid leukemia," The New England Journal of Medicine, vol. 358, no. 18, pp. 1919-1928, 2008.
6. S. Pfefer, M. Zavolan, F. A. Grässer et al., "Identifcation of virus-encoded microRNAs," Science, vol. 304, no. 5671, pp. 734-736, 2004.
7. B. T. Moore and P. Xiao, "MiRNAs in bone diseases," MicroRNA, vol. 2, no. 1, pp. 20-31, 2013.
8. S. Miyaki and H. Asahara, "Macro view of microRNA function in osteoarthritis," Nature Reviews Rheumatology, vol. 8, no. 9, pp. 543-552, 2012.
9. A. Rodriguez, S. Grifths-Jones, J. L. Ashurst, and A. Bradley, "Identifcation of mammalian microRNA host genes and transcription units," Genome Research, vol. 14, no. 10, pp. 1902-1910, 2004.
10. Y. Lee, K. Jeon, J.-T. Lee, S. Kim, and V. N. Kim, "MicroRNA maturation: stepwise processing and subcellular localization," The EMBO Journal, vol. 21, no. 17, pp. 4663-4670, 2002.
11. G. Gibson and H. Asahara, "microRNAs and cartilage," Journal of Orthopaedic Research, vol. 31, no. 9, pp. 1333-1344, 2013.
12. D. P. Bartel, "microRNAs: target recognition and regulatory functions," Cell, vol. 136, no. 2, pp. 215-233, 2009.
13. Q. Chen, W. Liu, K. M. Sinha, H. Yasuda, and B. de Crombrug-ghe, "Identifcation and characterization of microRNAs controlled by the osteoblast-specifc transcription factor osterix," PLoS ONE, vol. 8, no. 3, Article ID e58104, 2013.
14. H. Li, H. Xie, W. Liu et al., "A novel microRNA targeting HDAC5 regulates osteoblast diferentiation in mice and contributes to primary osteoporosis in humans," The Journal of Clinical Investigation, vol. 119, no. 12, pp. 3666-3677, 2009.
15. J. Gao, T. Yang, J. Han et al., "microRNA expression during osteogenic diferentiation of human multipotent mesenchymal stromal cells from bone marrow," Journal of Cellular Biochemistry, vol. 112, no. 7, pp. 1844-1856, 2011.
16. T. S. Lisse, R. F. Chun, S. Rieger, J. S. Adams, and M. Hewi-son, "Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts," Journal of Bone and Mineral Research, vol. 28, no. 6, pp. 1478-1488, 2013.
17. J. Guo, F. Ren, Y. Wang et al., "miR-764-5p promotes osteoblast diferentiation through inhibition of CHIP/STUB1 expression," Journal of Bone and Mineral Research, vol. 27, no. 7, pp. 1607-1618, 2012.
18. J. Zhang, Q. Tu, L. F. Bonewald et al., "Efects of miR-335-5p in modulating osteogenic diferentiation by specifcally downregulating Wnt antagonist DKK1," Journal of Bone and Mineral Research, vol. 26, no. 8, pp. 1953-1963, 2011.
19. M. Q. Hassan, Y. Maeda, H. Taipaleenmaki et al., "miR-218 directs a Wnt signaling circuit to promote diferentiation of osteoblasts and osteomimicry of metastatic cancer cells," The Journal of Biological Chemistry, vol. 287, no. 50, pp. 42084-42092, 2012.
20. K. Kapinas, C. B. Kessler, and A. M. Delany, "miR-29 suppression of osteonectin in osteoblasts: regulation during difer-entiation and by canonical Wnt signaling," Journal of Cellular Biochemistry, vol. 108, no. 1, pp. 216-224, 2009.
21. T. Wang and Z. Xu, "MiR-27 promotes osteoblast diferentiation by modulating Wnt signaling," Biochemical and Biophysical Research Communications, vol. 402, no. 2, pp. 186-189, 2010.
22. W. Hu, Y. Ye, W. Zhang, J. Wang, A. Chen, and F. Guo, "miR-142-3p promotes osteoblast diferentiation by modulating Wnt signaling," Molecular Medicine Reports, vol. 7, no. 2, pp. 689-693, 2013.
23. Y. Mizuno, Y. Tokuzawa, Y. Ninomiya et al., "miR-210 promotes osteoblastic diferentiation through inhibition of AcvR1b," FEBS Letters, vol. 583, no. 13, pp. 2263-2268, 2009.
24. E. Luzi, F. Marini, S. C. Sala, I. Tognarini, G. Galli, and M. L. Brandi, "Osteogenic diferentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor," Journal of Bone and Mineral Research, vol. 23, no. 2, pp. 287-295, 2008.
25. S. K. Laine, J. J. Alm, S. P. Virtanen, H. T. Aro, and T. K. Laitala-Leinonen, "MicroRNAs miR-96, miR-124, and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells," Journal of Cellular Biochemistry, vol. 113, no. 8, pp. 2687-2695, 2012.
26. F. E. Nicolas and T. Dalmay, "New evidence supports the notion that microRNA-140 may play a role in the early stages of bone development," Arthritis and Rheumatism, vol. 65, no. 6, pp. 1668-1669, 2013.
27. K. Shi, J. Lu, Y. Zhao et al., "MicroRNA-214 suppresses osteogenic diferentiation of C2C12 myoblast cells by targeting Osterix," Bone, vol. 55, no. 2, pp. 487-494, 2013.
28. J.-F. Zhang, W.-M. Fu, M.-L. He et al., "MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix," Molecular Biology of the Cell, vol. 22, no. 21, pp. 3955-3961, 2011.
29. Z. Li, M. Q. Hassan, S. Volinia et al., "A microRNA signature for a BMP2-induced osteoblast lineage commitment program," Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 37, pp. 13906-13911, 2008.
30. H. Inose, H. Ochi, A. Kimura et al., "A microRNA regulatory mechanism of osteoblast diferentiation," Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 49, pp. 20794-20799, 2009.
31. Y. Zeng, X. Qu, H. Li et al., "microRNA-100 regulates osteogenic diferentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2," FEBS Letters, vol. 586, no. 16, pp. 2375-2381, 2012.
32. T. Wu, M. Xie, X. Wang, X. Jiang, J. Li, and H. Huang, "miR-155 modulates TNF-alpha-inhibited osteogenic diferentiation by targeting SOCS1 expression," Bone, vol. 51, no. 3, pp. 498-505, 2012.
33. T. Itoh, M. Ando, Y. Tsukamasa, and Y. Akao, "Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast diferentiation is regulated by microRNA-370," FEBS Letters, vol. 586, no. 12, pp. 1693-1701, 2012.
34. F. Yu, Y. Cui, X. Zhou, X. Zhang, and J. Han, "Osteogenic difer-entiation of human ligament fbroblasts induced by conditioned medium of osteoclast-like cells," BioScience Trends, vol. 5, no. 2, pp. 46-51, 2011.
35. E.-J. Kim, I.-H. Kang, J. W. Lee, W.-G. Jang, and J.-T. Koh, "MiR-433 mediates ERRgamma-suppressed osteoblast diferentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells," Life Sciences, vol. 92, no. 10, pp. 562-568, 2013.
36. T. Wu, H. Zhou, Y. Hong, J. Li, X. Jiang, and H. Huang, "miR-30 family members negatively regulate osteoblast diferentiation," The Journal of Biological Chemistry, vol. 287, no. 10, pp. 7503-7511, 2012.
37. B. Bakhshandeh, M. Soleimani, M. Hafzi, S. H. Paylakhi, and N. Ghaemi, "microRNA signature associated with osteogenic lineage commitment," Molecular Biology Reports, vol. 39, no. 7, pp. 7569-7581, 2012.
38. X. Wang, B. Guo, Q. Li et al., "miR-214 targets ATF4 to inhibit bone formation," Nature Medicine, vol. 19, no. 1, pp. 93-100, 2013.
39. Y. Mizuno, K. Yagi, Y. Tokuzawa et al., "miR-125b inhibits osteoblastic diferentiation by down-regulation of cell proliferation," Biochemical and Biophysical Research Communications, vol. 368, no. 2, pp. 267-272, 2008.
40. K. M. Kim, S. J. Park, S.-H. Jung et al., "MiR-182 is a negative regulator of osteoblast proliferation, diferentiation, and skele-togenesis through targeting FoxO1," Journal of Bone and Mineral Research, vol. 27, no. 8, pp. 1669-1679, 2012.
41. T. Eskildsen, H. Taipaleenmäki, J. Stenvang et al., "MicroRNA-138 regulates osteogenic diferentiation of human stromal (mesenchymal) stem cells in vivo," Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 15, pp. 6139-6144, 2011.
42. Y. J. Kim, S. W. Bae, S. S. Yu, Y. C. Bae, and J. S. Jung, "miR-196a regulates proliferation and osteogenic diferentiation in mesenchymal stem cells derived from human adipose tissue," Journal of Bone and Mineral Research, vol. 24, no. 5, pp. 816-825, 2009.
43. S. Kahai, S.-C. Lee, D. Y. Lee et al., "MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7," PLoS ONE, vol. 4, no. 10, Article ID e7535, 2009.
44. T. Sugatani, J. Vacher, and K. A. Hruska, "A microRNA expression signature of osteoclastogenesis," Blood, vol. 117, no. 13, pp. 3648-3657, 2011.
45. F. Mizoguchi, Y. Izu, T. Hayata et al., "Osteoclast-specifc dicer gene defciency suppresses osteoclastic bone resorption," Journal of Cellular Biochemistry, vol. 109, no. 5, pp. 866-875, 2010.
46. Y. Bae, T. Yang, H.-C. Zeng et al., "miRNA-34c regulates Notch signaling during bone development," Human Molecular Genetics, vol. 21, no. 13, Article ID dds129, pp. 2991-3000, 2012.
47. T. Sugatani and K. A. Hruska, "Impaired micro-RNA pathways diminish osteoclast diferentiation and function," The Journal of Biological Chemistry, vol. 284, no. 7, pp. 4667-4678, 2009.
48. T. Kagiya and S. Nakamura, "Expression profling of microR-NAs in RAW264.7 cells treated with a combination of tumor necrosis factor alpha and RANKL during osteoclast diferentia-tion," Journal of Periodontal Research, vol. 48, no. 3, pp. 373-385, 2013.
49. M. Rossi, M. R. Pitari, N. Amodio et al., "miR-29b negatively regulates human osteoclastic cell diferentiation and function: implications for the treatment of multiple myeloma-related bone disease," Journal of Cellular Physiology, vol. 228, no. 7, pp. 1506-1515, 2013.
50. T. Nakasa, H. Shibuya, Y. Nagata, T. Niimoto, and M. Ochi, "The inhibitory efect of microRNA-146a expression on bone destruction in collagen-induced arthritis," Arthritis and Rheumatism, vol. 63, no. 6, pp. 1582-1590, 2011.
51. J. Zhang, H. Zhao, J. Chen et al., "Interferon-β-induced miR-155 inhibits osteoclast diferentiation by targeting SOCS1 and MITF," FEBS Letters, vol. 586, no. 19, pp. 3255-3262, 2012.
52. S. Suomi, H. Taipaleenmäki, A. Seppänen et al., "MicroRNAs regulate osteogenesis and chondrogenesis of mouse bone marrow stromal cells," Gene Regulation and Systems Biology, vol. 2, pp. 177-191, 2008.
53. B. Yang, H. Guo, Y. Zhang, S. Dong, and D. Ying, "The microRNA expression profles of mouse mesenchymal stem cell during chondrogenic diferentiation," BMB Reports, vol. 44, no. I, pp. 28-33, 2011.
54. J. Han, T. Yang, J. Gao et al., "Specifc microRNA expression during chondrogenesis of human mesenchymal stem cells," International Journal of Molecular Medicine, vol. 25, no. 3, pp. 377-384, 2010.
55. Z. Zhang, Y. Kang, Z. Zhang et al., "Expression of microRNAs during chondrogenesis of human adipose-derived stem cells," Osteoarthritis and Cartilage, vol. 20, no. 12, pp. 1638-1646, 2012.
56. B. Yang, H. Guo, Y. Zhang, L. Chen, D. Ying, and S. Dong, "Microrna-145 regulates chondrogenic diferentiation of mes-enchymal stem cells by targeting Sox9," PLoS ONE, vol. 6, no. 7, Article ID e21679, 2011.
57. J. Song, D. Kim, C.-H. Chun, and E.-J. Jin, "microRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin," Cell Communication and Signaling, vol. II, article 66, 2013.
58. Y. Zhang, J. Jia, S. Yang, X. Liu, S. Ye, and H. Tian, "MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes," Experimental and Molecular Medicine, vol. 46, no. 2, article e79, 2014.
59. N. Zhong, J. Sun, Z. Min et al., "MicroRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression," Osteoarthritis and Cartilage, vol. 20, no. 6, pp. 593-602, 2012.
60. N. Akhtar, Z. Rasheed, S. Ramamurthy, A. N. Anbazhagan, F. R. Voss, and T. M. Haqqi, "microRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chon-drocytes," Arthritis & Rheumatism, vol. 62, no. 5, pp. 1361-1371, 2010.
61. S. Díaz-Prado, C. Cicione, E. Muinõs-López et al., "Characterization of microRNA expression profles in normal and osteoarthritic human chondrocytes," BMC Musculoskeletal Disorders, vol. 13, article 144, 2012.
62. L. Jin, J. Zhao, W. Jing et al., "Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro," International Journal of Molecular Medicine, vol. 34, no. 2, pp. 451-463, 2014.
63. A. Martinez-Sanchez, K. A. Dudek, and C. L. Murphy, "Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)," The Journal of Biological Chemistry, vol. 287, no. 2, pp. 916-924, 2012.
64. S. Miyaki, T. Nakasa, S. Otsuki et al., "MicroRNA-140 is expressed in diferentiated human articular chondrocytes and modulates interleukin-1 responses," Arthritis & Rheumatism, vol. 60, no. 9, pp. 2723-2730, 2009.
65. S. Miyaki, T. Sato, A. Inoue et al., "microRNA-140 plays dual roles in both cartilage development and homeostasis," Genes & Development, vol. 24, no. 11, pp. 1173-1185, 2010.
66. T. Matsukawa, T. Sakai, T. Yonezawa et al., "MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes," Arthritis Research and Terapy, vol. 15, no. 1, article R28, 2013.
67. S. J. Park, E. J. Cheon, M. H. Lee, and H. A. Kim, "microRNA-127-5p regulates matrix metalloproteinase 13 expression and interleukin-1β-induced catabolic efects in human chondro-cytes," Arthritis & Rheumatism, vol. 65, no. 12, pp. 3141-3152, 2013.
68. N. Akhtar and T. M. Haqqi, "MicroRNA-199a regulates the expression of cyclooxygenase-2 in human chondrocytes," Annals of the Rheumatic Diseases, vol. 71, no. 6, pp. 1073-1080, 2012.
69. S. J. Park, E. J. Cheon, and H. A. Kim, "microRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic efects in human articular chondrocytes," Osteoarthri-tis and Cartilage, vol. 21, no. 7, pp. 981-989, 2013.
70. K. A. Dudek, J. E. Lafont, A. Martinez-Sanchez, and C. L. Murphy, "Type II collagen expression is regulated by tissue-specifc miR-675 in human articular chondrocytes," The Journal of Biological Chemistry, vol. 285, no. 32, pp. 24381-24387, 2010.
71. P. J. Marie, "Transcription factors controlling osteoblastogene-sis," Archives of Biochemistry and Biophysics, vol. 473, no. 2, pp. 98-105, 2008.
72. H. Shibuya, T. Nakasa, N. Adachi et al., "Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast diferentiation," Modern Rheumatology, vol. 23, no. 4, pp. 674-685, 2013.
73. M. Mann, O. Barad, R. Agami, B. Geiger, and E. Hornstein, "miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate," Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 36, pp. 15804-15809, 2010.
74. B. S. Cobb, T. B. Nesterova, E. Tompson et al., "T cell lineage choice and diferentiation in the absence of the RNase III enzyme Dicer," The Journal of Experimental Medicine, vol. 201, no. 9, pp. 1367-1373, 2005.
75. C. Kanellopoulou, A. L. Kung, S. Ganesan et al., "Dicer-defcient mouse embryonic stem cells are defective in diferentiation and centromeric silencing," Genes and Development, vol. 19, no. 4, pp. 489-501, 2005.
76. S. Kwan Tat, D. Lajeunesse, J.-P. Pelletier, and J. Martel-Pelletier, "Targeting subchondral bone for treating osteoarthritis: what is the evidence?" Best Practice and Research: Clinical Rheumatology, vol. 24, no. 1, pp. 51-70, 2010.
77. D. Iliopoulos, K. N. Malizos, P. Oikonomou, and A. Tsezou, "Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and infammatory networks," PLoS ONE, vol. 3, no. 11, Article ID e3740, 2008.
78. S. W. Jones, G. Watkins, N. Le Good et al., "The identifcation of diferentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13," Osteoarthritis and Cartilage, vol. 17, no. 4, pp. 464-472, 2009.
79. K. Yamasaki, T. Nakasa, S. Miyaki et al., "Expression of MicroRNA-146a in osteoarthritis cartilage," Arthritis and Rheumatism, vol. 60, no. 4, pp. 1035-1041, 2009.
80. T. Ukai, M. Sato, H. Akutsu, A. Umezawa, and J. Mochida, "MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism," Journal of Orthopaedic Research, vol. 30, no. 12, pp. 1915-1922, 2012.
81. M. J. Pefers, X. Liu, and P. D. Clegg, "Transcriptomic signatures in cartilage ageing," Arthritis Research and Terapy, vol. 15, no. 4, article R98, 2013.
82. Y.-J. Guan, X. Yang, L. Wei, and Q. Chen, "MiR-365: a mechanosensitive microRNA stimulates chondrocyte diferen-tiation through targeting histone deacetylase 4," The FASEB Journal, vol. 25, no. 12, pp. 4457-4466, 2011.
83. W. Dunn, G. DuRaine, and A. H. Reddi, "Profling microRNA expression in bovine articular cartilage and implications for mechanotransduction," Arthritis & Rheumatism, vol. 60, no. 8, pp. 2333-2339, 2009.
84. R. Liu-Bryan and R. Terkeltaub, "Chondrocyte innate immune myeloid diferentiation factor 88-dependent signaling drives procatabolic efects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice," Arthritis and Rheumatism, vol. 62, no. 7, pp. 2004-2012, 2010.
85. X. Li, G. Gibson, J.-S. Kim et al., "MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis," Gene, vol. 480, no. 1-2, pp. 34-41, 2011.
86. X. Li, J. S. Kroin, R. Kc et al., "Altered spinal MicroRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints," Journal of Bone and Mineral Research, vol. 28, no. 12, pp. 2512-2522, 2013.
87. M. Ceppi, P. M. Pereira, I. Dunand-Sauthier et al., "MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells," Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 8, pp. 2735-2740, 2009.
88. K. D. Taganov, M. P. Boldin, K.-J. Chang, and D. Baltimore, "NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses," Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 33, pp. 12481-12486, 2006.
89. J. Li, J. Huang, L. Dai et al., "miR-146a, an IL-1beta responsive miRNA, induces vascular endothelial growth factor and chon-drocyte apoptosis by targeting Smad4," Arthritis Research and Terapy, vol. 14, no. 2, article R75, 2012.
90. M. M. Abouheif, T. Nakasa, H. Shibuya, T. Niimoto, W. Kongcharoensombat, and M. Ochi, "Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro," Rheumatology, vol. 49, no. 11, pp. 2054-2060, 2010.
91. J. Xu, Y. Kang, W.-M. Liao, and L. Yu, "MiR-194 regulates chondrogenic diferentiation of human adipose-derived stem cells by targeting Sox5," PLoS ONE, vol. 7, no. 3, Article ID e31861, 2012.
92. Z.-J. Liang, H. Zhuang, G.-X. Wang et al., "MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1β-stimulated human articular chondrocyte C28/I2 cells," Infammation Research, vol. 61, no. 5, pp. 503-509, 2012.
93. L. Dai, X. Zhang, X. Hu, C. Zhou, and Y. Ao, "Silencing of microRNA-101 prevents IL-1beta-induced extracellular matrix degradation in chondrocytes," Arthritis Research and Terapy, vol. 14, no. 6, article R268, 2012.
94. D. Zhang, X. Cao, J. Li, and G. Zhao, "MiR-210 inhibits NF-κB signaling pathway by targeting DR6 in osteoarthritis," Scientifc Reports, vol. 5, article 12775, 2015.
95. Z. C. Li, N. Han, X. Li et al., "Decreased expression of microRNA-130a correlates with TNF-α in the development of osteoarthritis," International Journal of Clinical and Experimental Pathology, vol. 8, no. 3, pp. 2555-2564, 2015.
96. J.-H. Kim and S.-J. Kim, "Overexpression of MicroRNA-25 by withaferin A induces cyclooxygenase-2 expression in rabbit articular chondrocytes," Journal of Pharmacological Sciences, vol. 125, no. 1, pp. 83-90, 2014.
97. P. Santini, L. Politi, P. D. Vedova, R. Scandurra, and A. S. d,Abusco, "The infammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis," Rheumatology International, vol. 34, no. 5, pp. 711-716, 2014.
98. C. Y. L. Onju Ham, B.-W. Song, S.-Y. Lee et al., "Upregulation of miR-23b enhances the autologous therapeutic potential for degenerative arthritis by targeting PRKACB in synovial fuid-derived mesenchymal stem cells from patients," Molecules and Cells, vol. 37, no. 6, pp. 449-456, 2014.
99. S. W. Jones, G. Watkins, N. Le Good et al., "The identifcation of diferentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13," Osteoarthritis and Cartilage, vol. 17, no. 4, pp. 464-472, 2009.
100. J. Song, D. Kim, C. H. Lee, M. S. Lee, C.-H. Chun, and E.-J. Jin, "MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis," Journal of Biomedical Science, vol. 20, article 31, 2013.
101. S. Gilad, E. Meiri, Y. Yogev et al., "Serum microRNAs are promising novel biomarkers," PLoS ONE, vol. 3, no. 9, Article ID e3148, 2008.
102. N. Kosaka, H. Iguchi, and T. Ochiya, "Circulating microRNA in body fuid: a new potential biomarker for cancer diagnosis and prognosis," Cancer Science, vol. 101, no. 10, pp. 2087-2092, 2010.
103. C. H. Lawrie, S. Gal, H. M. Dunlop et al., "Detection of elevated levels of tumour-associated microRNAs in serum of patients with difuse large B-cell lymphoma," British Journal of Haematology, vol. 141, no. 5, pp. 672-675, 2008.
104. K. Murata, H. Yoshitomi, S. Tanida et al., "Plasma and synovial fuid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis," Arthritis Research and Terapy, vol. 12, no. 3, article R86, 2010.
105. A. Okuhara, T. Nakasa, H. Shibuya et al., "Changes in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis," Modern Rheumatology, vol. 22, no. 3, pp. 446-457, 2012.
106. L. T. T. Le, T. E. Swingler, and I. M. Clark, "Review: the role of microRNAs in osteoarthritis and chondrogenesis," Arthritis & Rheumatism, vol. 65, no. 8, pp. 1963-1974, 2013.
107. Y. Nagata, T. Nakasa, Y. Mochizuki et al., "Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microRNA-15a," Arthritis and Rheumatism, vol. 60, no. 9, pp. 2677-2683, 2009.
108. P. D. Mariner, E. Johannesen, and K. S. Anseth, "Manipulation of miRNA activity accelerates osteogenic diferentiation of hMSCs in engineered 3D scafolds," Journal of Tissue Engineering and Regenerative Medicine, vol. 6, no. 4, pp. 314-324, 2012.
109. M. Koning, P. M. N. Werker, D. W. J. van der Schaf, R. A. Bank, and M. C. Harmsen, "MicroRNA-1 and microRNA-206 Improve diferentiation potential of human satellite cells: a novel approach for tissue engineering of skeletal muscle," Tissue Engineering Part A, vol. 18, no. 9-10, pp. 889-898, 2012.