MiR-433 mediates ERRγ-suppressed osteoblast differentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells

Life Sciences

Volumn 92, Issue 10, 2013, Pages 562-568

  Kim, Eun Jung ^a,b   Kang, In Hong ^a   Lee, Jeong Woong ^b   Jang, Won Gu ^a,b   Koh, Jeong Tae ^a  

^a Chonnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

ERR ; MicroRNA; miR 433; Osteoblasts; Runx2

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR RELATED RECEPTOR GAMMA; MESSENGER RNA; MICRORNA; MICRORNA 443; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALGORITHM; ANIMAL CELL; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; MARKER GENE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PREDICTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALKALINE PHOSPHATASE; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DNA PRIMERS; MESENCHYMAL STROMAL CELLS; MICE; MICRORNAS; OSTEOBLASTS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84875475772     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.01.015     Document Type: Article

References (26)

1. V. Ambros, and X. Chen The regulation of genes and genomes by small RNAs Development 134 2007 1635 1641
2. C. Banerjee, L.R. McCabe, J.Y. Choi, S.W. Hiebert, J.L. Stein, and G.S. Stein Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex J Cell Biochem 66 1997 1 8
3. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
4. R.W. Carthew, and E.J. Sontheimer Origins and mechanisms of miRNAs and siRNAs Cell 136 2009 642 655
5. D. Chen, X. Ji, M.A. Harris, J.Q. Feng, G. Karsenty, and A.J. Celeste Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages J Cell Biol 142 1998 295 305
6. P. Ducy, and G. Karsenty Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene Mol Cell Biol 15 1995 1858 1869
7. P. Ducy, R. Zhang, V. Geoffroy, A.L. Ridall, and G. Karsenty Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 89 1997 747 754
8. P. Ducy, M. Starbuck, M. Priemel, J. Shen, G. Pinero, and V. Geoffroy A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development Genes Dev 13 1999 1025 1036
9. T. Eskildsen, H. Taipaleenmaki, J. Stenvang, B.M. Abdallah, N. Ditzel, and A.Y. Nossent MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo Proc Natl Acad Sci U S A 108 2011 6139 6144
10. R.T. Franceschi, C. Ge, G. Xiao, H. Roca, and D. Jiang Transcriptional regulation of osteoblasts Ann N Y Acad Sci 1116 2007 196 207
11. V. Giguere To ERR, in the estrogen pathway Trends Endocrinol Metab 13 2002 220 225
12. J.W. Hagen, and E.C. Lai microRNA control of cell-cell signaling during development and disease Cell Cycle 7 2008 2327 2332
13. R. Hu, W. Liu, H. Li, L. Yang, C. Chen, and Z.Y. Xia A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation J Biol Chem 286 2011 12328 12339
14. W.G. Jang, E.J. Kim, I.H. Bae, K.N. Lee, Y.D. Kim, and D.K. Kim Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2 Bone 48 2011 885 893
15. A. Javed, G.L. Barnes, B.O. Jasanya, J.L. Stein, L. Gerstenfeld, and J.B. Lian Runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins Mol Cell Biol 21 2001 2891 2905
16. B.C. Jeong, Y.S. Lee, Y.Y. Park, I.H. Bae, D.K. Kim, and S.H. Koo The orphan nuclear receptor estrogen receptor-related receptor gamma negatively regulates BMP2-induced osteoblast differentiation and bone formation J Biol Chem 284 2009 14211 14218
17. B.C. Jeong, Y.S. Lee, I.H. Bae, C.H. Lee, H.I. Shin, and H.J. Ha The orphan nuclear receptor SHP is a positive regulator of osteoblastic bone formation J Bone Miner Res 25 2010 262 274
18. T. Komori Regulation of skeletal development by the Runx family of transcription factors J Cell Biochem 95 2005 445 453
19. M.H. Lee, Y.J. Kim, H.J. Kim, H.D. Park, A.R. Kang, and H.M. Kyung BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression J Biol Chem 278 2003 34387 34394
20. Z. Li, M.Q. Hassan, S. Volinia, A.J. van Wijnen, J.L. Stein, and C.M. Croce A microRNA signature for a BMP2-induced osteoblast lineage commitment program Proc Natl Acad Sci U S A 105 2008 13906 13911
21. Z. Li, M.Q. Hassan, M. Jafferji, R.I. Aqeilan, R. Garzon, and C.M. Croce Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation J Biol Chem 284 2009 15676 15684
22. G. Mundy, R. Garrett, S. Harris, J. Chan, D. Chen, and G. Rossini Stimulation of bone formation in vitro and in rodents by statins Science 286 1999 1946 1949
23. S. Sanyal, J.Y. Kim, H.J. Kim, J. Takeda, Y.K. Lee, and D.D. Moore Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms J Biol Chem 277 2002 1739 1748
24. G. Song, and L. Wang Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma Nucleic Acids Res 36 2008 5727 5735
25. P. Trang, J.B. Weidhaas, and F.J. Slack MicroRNAs as potential cancer therapeutics Oncogene 27 Suppl. 2 2008 S52 S57
26. J.F. Zhang, W.M. Fu, M.L. He, H. Wang, W.M. Wang, and S.C. Yu MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix Mol Biol Cell 22 2011 3955 3961