-
2
-
-
0033958644
-
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes
-
Nikoulina S.E., Ciaraldi T.P., Mudailar S., Mohideen P., Carter L., Henry R.R. (2000). Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. Diabetes, 49, 263-271.
-
(2000)
Diabetes
, vol.49
, pp. 263-271
-
-
Nikoulina, S.E.1
Ciaraldi, T.P.2
Mudailar, S.3
Mohideen, P.4
Carter, L.5
Henry, R.R.6
-
3
-
-
0028675873
-
Alzheimer's disease-like phosphorylation of the microtubule-associated protein Tau by glycogen synthase kinase-3 in transfected mammalian cells
-
Lovestone S., Reynolds C.H., Latimer D., Davis D.R., Anderton B.H., Gallo J.M., Hanger D., Mulot S., Marquardt B. (1994). Alzheimer's disease-like phosphorylation of the microtubule-associated protein Tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr. Biol., 4, 1077-1086.
-
(1994)
Curr. Biol.
, vol.4
, pp. 1077-1086
-
-
Lovestone, S.1
Reynolds, C.H.2
Latimer, D.3
Davis, D.R.4
Anderton, B.H.5
Gallo, J.M.6
Hanger, D.7
Mulot, S.8
Marquardt, B.9
-
4
-
-
0036273020
-
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and infl ammation
-
Martinez A., Castro A., Dorronsoro I., Alonso M. (2002). Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and infl ammation. Med. Res. Rev., 22, 373-384.
-
(2002)
Med. Res. Rev.
, vol.22
, pp. 373-384
-
-
Martinez, A.1
Castro, A.2
Dorronsoro, I.3
Alonso, M.4
-
5
-
-
0037013685
-
Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors
-
Naerum L., Norskov-Lauritsen L., Olesen P.H. (2002). Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. Bioorg. Med. Chem. Lett., 12, 1525-1528.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1525-1528
-
-
Naerum, L.1
Norskov-Lauritsen, L.2
Olesen, P.H.3
-
6
-
-
0033776383
-
Selective small molecule inhibitors of glycogen synthase kinase 3 modulate glycogen metabolism and gene transcription
-
Coghlan M.P., Culbert A.A., Cross D.A.E., Corcoran S.L., Yates J.D., Pearce N.J., Rausch O.L., Murphy G.J., Carter P.S., Cox L.R., Mills D., Brown M.J., Haigh D., Ward R.W., Smith D.G., Murray K.J., Reith A.D., Holder J. (2000). Selective small molecule inhibitors of glycogen synthase kinase 3 modulate glycogen metabolism and gene transcription. Chem. Biol., 7, 793-803.
-
(2000)
Chem. Biol.
, vol.7
, pp. 793-803
-
-
Coghlan, M.P.1
Culbert, A.A.2
Cross, D.A.E.3
Corcoran, S.L.4
Yates, J.D.5
Pearce, N.J.6
Rausch, O.L.7
Murphy, G.J.8
Carter, P.S.9
Cox, L.R.10
Mills, D.11
Brown, M.J.12
Haigh, D.13
Ward, R.W.14
Smith, D.G.15
Murray, K.J.16
Reith, A.D.17
Holder, J.18
-
7
-
-
1642286981
-
GSK-3 inhibitors: Discoveries and developments
-
Alonso M., Martinez A. (2004). GSK-3 inhibitors: Discoveries and developments. Curr. Med. Chem., 11, 755-763.
-
(2004)
Curr. Med. Chem.
, vol.11
, pp. 755-763
-
-
Alonso, M.1
Martinez, A.2
-
9
-
-
0036799220
-
Inhibitors of Glycogen Synthase Kinase 3 (GSK-3): Future drugs for the treatment of unmet diseases?
-
Dorronsoro I., Castro A., Martinez A. (2002). Inhibitors of Glycogen Synthase Kinase 3 (GSK-3): Future drugs for the treatment of unmet diseases? Exp. Opin. Ther. Patent, 12, 1527-1536.
-
(2002)
Exp. Opin. Ther. Patent
, vol.12
, pp. 1527-1536
-
-
Dorronsoro, I.1
Castro, A.2
Martinez, A.3
-
11
-
-
27744495564
-
Marine compounds for the therapeutic treatment of neurological disorders
-
Alonso D., Castro A., Martinez A. (2005). Marine compounds for the therapeutic treatment of neurological disorders. Exp. Opin. Ther. Patents, 15, 1377-1386.
-
(2005)
Exp. Opin. Ther. Patents
, vol.15
, pp. 1377-1386
-
-
Alonso, D.1
Castro, A.2
Martinez, A.3
-
12
-
-
10544237275
-
Isomers and tautomers of hymenialdisine and debromohymenialfisine
-
Williams D.H., Faulkner J. (1996). Isomers and tautomers of hymenialdisine and debromohymenialfisine. Nat. Prod. Lett., 9, 57-64.
-
(1996)
Nat. Prod. Lett.
, vol.9
, pp. 57-64
-
-
Williams, D.H.1
Faulkner, J.2
-
13
-
-
0001006448
-
Isolation and X-ray cristal structure of a novel bromo-compound from two marine sponges
-
Cimino G., De Rosa S., De Stefano S., Mazzarella L., Puliti R., Sodano. (1982). Isolation and X-ray cristal structure of a novel bromo-compound from two marine sponges. Tetrahedrom Lett., 23, 767-768.
-
(1982)
Tetrahedrom Lett.
, vol.23
, pp. 767-768
-
-
Cimino, G.1
De Rosa, S.2
De Stefano, S.3
Mazzarella, L.4
Puliti, R.5
Sodano6
-
15
-
-
0037122752
-
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of nitogen-activated protein kinase-1 (MEK-1)
-
Tasdemir D., Mallon R., Greenstein M., Felderg L.R., Kim S.C., Collins K., Wojciechowicz D., Mangalindan G., Concepción G., Harper M.K., Ireland C.M. (2002). Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of nitogen-activated protein kinase-1 (MEK-1). J. Med. Chem., 45, 529-532.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 529-532
-
-
Tasdemir, D.1
Mallon, R.2
Greenstein, M.3
Felderg, L.R.4
Kim, S.C.5
Collins, K.6
Wojciechowicz, D.7
Mangalindan, G.8
Concepción, G.9
Harper, M.K.10
Ireland, C.M.11
-
16
-
-
3142761620
-
Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine
-
Sharma V., Tepr J.J., (2004). Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. Bioorg. Med. Chem. Lett., 14, 4319-4321.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 4319-4321
-
-
Sharma, V.1
Tepr, J.J.2
-
17
-
-
0034010742
-
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent
-
Meijer L., Thunnissen A.-M.W.H., White A.W., Garnier M., Nikolic M., Tsai L.H., Walter J., Cleverley K.E., Salinas P.C., Wu Y.Z., Biernat J., Mandelkow E.M., Kim S.H., Pettit G.R. (2001). Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem. Biol., 7, 51-63.
-
(2001)
Chem. Biol.
, vol.7
, pp. 51-63
-
-
Meijer, L.1
Thunnissen, A.-M.W.H.2
White, A.W.3
Garnier, M.4
Nikolic, M.5
Tsai, L.H.6
Walter, J.7
Cleverley, K.E.8
Salinas, P.C.9
Wu, Y.Z.10
Biernat, J.11
Mandelkow, E.M.12
Kim, S.H.13
Pettit, G.R.14
-
18
-
-
3042599015
-
Inhibition of cytokine production by hymenialdisine derivatives
-
Sharma V., Lansdell T.A., Jin G., Tepe J.J. (2004). Inhibition of cytokine production by hymenialdisine derivatives. J. Med. Chem., 47, 3700-3703.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 3700-3703
-
-
Sharma, V.1
Lansdell, T.A.2
Jin, G.3
Tepe, J.J.4
-
19
-
-
0030770363
-
The natural product hymenialdisine ihbibits intelukin-8 production in U937 cells by inhibition of nuclear factor-B
-
Bretón J., Chabot-Fletcher M.C. (1997). The natural product hymenialdisine ihbibits intelukin-8 production in U937 cells by inhibition of nuclear factor-B. J. Pharmacol. Exp. Ther., 282, 459-466.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.282
, pp. 459-466
-
-
Bretón, J.1
Chabot-Fletcher, M.C.2
-
20
-
-
0030612279
-
Inhibition of NFΚB-mediated interleukin-1b-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine
-
Roshak A., Jackson J.R., Chabot-Fletcher M., Marshall L.A. (1997). Inhibition of NFΚB-mediated interleukin-1b-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine. J. Pharmacol. Exp. Ther., 283, 955-996.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 955-996
-
-
Roshak, A.1
Jackson, J.R.2
Chabot-Fletcher, M.3
Marshall, L.A.4
-
21
-
-
0028801824
-
Total synthesis of hymenialdisine and debromohymenialsisine
-
Annoura H., Tatsuaka T. (1995). Total synthesis of hymenialdisine and debromohymenialsisine. Tetrahedrom Lett., 36, 413-416.
-
(1995)
Tetrahedrom Lett.
, vol.36
, pp. 413-416
-
-
Annoura, H.1
Tatsuaka, T.2
-
22
-
-
0031019028
-
Synthesis of C11N5 marine sponges alkaloids
-
Xu Y.-H., Yakushijin K., Horne D.A. (1997). Synthesis of C11N5 marine sponges alkaloids. J. Org. Chem., 62, 456-464.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 456-464
-
-
Xu, Y.-H.1
Yakushijin, K.2
Horne, D.A.3
-
23
-
-
1542381392
-
Synthesis and target identification of hymenialdidine analogs
-
Wan Y., Hur W., Cho Y.C., Liu Y., Adria F., Lozach O., Bacch S., Mayer T., Fabbro D., Meijer L., Gray N. (2004). Synthesis and target identification of hymenialdidine analogs. Chem. Biol., 11, 247-259.
-
(2004)
Chem. Biol.
, vol.11
, pp. 247-259
-
-
Wan, Y.1
Hur, W.2
Cho, Y.C.3
Liu, Y.4
Adria, F.5
Lozach, O.6
Bacch, S.7
Mayer, T.8
Fabbro, D.9
Meijer, L.10
Gray, N.11
-
24
-
-
29444445314
-
A new glycociamidine ring precursor: Syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (+/-)-endo-2-debromohymenialdisine
-
Papeo G., Posteri H., Borghi D., Varasi M. (2005). A new glycociamidine ring precursor: Syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (+/-)-endo-2-debromohymenialdisine. Org. Lett., 7, 5641-5644.
-
(2005)
Org. Lett.
, vol.7
, pp. 5641-5644
-
-
Papeo, G.1
Posteri, H.2
Borghi, D.3
Varasi, M.4
-
25
-
-
0036005604
-
Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
-
Hibino S., Chosi T. (2002). Simple indole alkaloids and those with a nonrearranged monoterpenoid unit. Nat. Prod. Rep., 19, 148-180.
-
(2002)
Nat. Prod. Rep.
, vol.19
, pp. 148-180
-
-
Hibino, S.1
Chosi, T.2
-
26
-
-
0000338886
-
Indole alkaloids from the tunicate Aplidium meridianum
-
Hernández L., Bal de Kier E., Puricelli L., Tatian M., Seldes A.M., Palermo J. (1998). Indole alkaloids from the tunicate Aplidium meridianum. J. Nat. Prod., 61, 1130-1132.
-
(1998)
J. Nat. Prod.
, vol.61
, pp. 1130-1132
-
-
Hernández, L.1
Bal de Kier, E.2
Puricelli, L.3
Tatian, M.4
Seldes, A.M.5
Palermo, J.6
-
27
-
-
1542509425
-
Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum
-
Gompel M., Leost M., Bal de Kier E., Puricelli L., Hernández Franco L., Palermo J., Meijer L. (2004). Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. Bioorg. Med. Chem. Lett., 14, 1703-1707.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 1703-1707
-
-
Gompel, M.1
Leost, M.2
Bal de Kier, E.3
Puricelli, L.4
Hernández Franco, L.5
Palermo, J.6
Meijer, L.7
-
28
-
-
0037383322
-
GSK-3: Tricks of the trade for a multi-tasking kinase
-
Doble B.W., Woodgett J.R. (2003). GSK-3: Tricks of the trade for a multi-tasking kinase. J. Cell. Sci., 116, 1175-1186.
-
(2003)
J. Cell. Sci.
, vol.116
, pp. 1175-1186
-
-
Doble, B.W.1
Woodgett, J.R.2
-
30
-
-
0034660684
-
Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin
-
Fresneda P., Molina P., Delgado S., Bleda, J.A. (2000). Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin. Tetrahedron Lett., 41, 4777-4780.
-
(2000)
Tetrahedron Lett.
, vol.41
, pp. 4777-4780
-
-
Fresneda, P.1
Molina, P.2
Delgado, S.3
Bleda, J.A.4
-
31
-
-
0034234304
-
Synthesis of indolylpyrimidines via cross-coupling of indolylboronic acid with chloropyrimidines: Facile synthesis of meridianin D
-
Jiang B., Yang C.G. (2000). Synthesis of indolylpyrimidines via cross-coupling of indolylboronic acid with chloropyrimidines: Facile synthesis of meridianin D. Heterocycles, 53, 1489-1498.
-
(2000)
Heterocycles
, vol.53
, pp. 1489-1498
-
-
Jiang, B.1
Yang, C.G.2
-
32
-
-
27544431953
-
Concise synthesis of meridianins by carbonylative alkynylation and four component pyrimidine synthesis
-
Karpov A., Merkul E., Rominger F., Müller T. (2005). Concise synthesis of meridianins by carbonylative alkynylation and four component pyrimidine synthesis. Angew. Chem. Int. Ed., 44, 6951-6956.
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 6951-6956
-
-
Karpov, A.1
Merkul, E.2
Rominger, F.3
Müller, T.4
-
33
-
-
0035940873
-
Identification of an indigo precursor from leaves of Isatis tinctoria
-
Maugard T., Enaud E., Choisy P., Legoy M.D. (2001). Identification of an indigo precursor from leaves of Isatis tinctoria. Phytochemistry, 58, 897-904.
-
(2001)
Phytochemistry
, vol.58
, pp. 897-904
-
-
Maugard, T.1
Enaud, E.2
Choisy, P.3
Legoy, M.D.4
-
34
-
-
0035079979
-
Expression and isolation of antimicrobial small molecules from soil DNA libraries
-
Mcaneil I.A., Ttiong C.L., Minor C., August P.R., Grossman T.H., Loiacono K.A., Lynch B.A., Phillipis T., Sundaramoorthi R., et al. (2001). Expression and isolation of antimicrobial small molecules from soil DNA libraries. J. Mol. Microbiol. Biotechnol., 3, 301-308.
-
(2001)
J. Mol. Microbiol. Biotechnol.
, vol.3
, pp. 301-308
-
-
Mcaneil, I.A.1
Ttiong, C.L.2
Minor, C.3
August, P.R.4
Grossman, T.H.5
Loiacono, K.A.6
Lynch, B.A.7
Phillipis, T.8
Sundaramoorthi, R.9
-
35
-
-
0042894451
-
Tyrian purple: 6,6'-Dibromoindigo and related compounds
-
Cooksey C.J. (2001). Tyrian purple: 6,6'-Dibromoindigo and related compounds. Mol., 6, 736-769.
-
(2001)
Mol.
, vol.6
, pp. 736-769
-
-
Cooksey, C.J.1
-
37
-
-
0035808457
-
Indirubins inhibit glycogen synthase kinase-3b and CDK5/p25, two kinases in abnormal Tau phosphorylation in Alzheimer disease-A property common to most CDK inhibitors
-
Leclerc S., Garnier M., Hoessel R., Marko D., Bibb J.A., Snyder G.L., Greengard P., Biernat J., Wu Y.Z., Mandelkow E.-M., et al. (2001). Indirubins inhibit glycogen synthase kinase-3b and CDK5/p25, two kinases in abnormal Tau phosphorylation in Alzheimer disease-A property common to most CDK inhibitors. J. Biol. Chem., 276, 251-260.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 251-260
-
-
Leclerc, S.1
Garnier, M.2
Hoessel, R.3
Marko, D.4
Bibb, J.A.5
Snyder, G.L.6
Greengard, P.7
Biernat, J.8
Wu, Y.Z.9
Mandelkow, E.-M.10
-
38
-
-
0033128165
-
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases
-
Hoessel R., Leclerc S., Endicott J., Noble M., Lawrie A., Tunnah P., Leost M., Damiens E., Marie D., Marko D., Niederberger E., Tang W., Eisenbrand G., Meijer L. (1999). Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat. Cell Biol., 1, 60-67.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 60-67
-
-
Hoessel, R.1
Leclerc, S.2
Endicott, J.3
Noble, M.4
Lawrie, A.5
Tunnah, P.6
Leost, M.7
Damiens, E.8
Marie, D.9
Marko, D.10
Niederberger, E.11
Tang, W.12
Eisenbrand, G.13
Meijer, L.14
-
40
-
-
4544308575
-
Niedermolekulare Verbindungen als Inhibitoren cyclin-abhangiger Kinasen
-
Huwe A., Mazitscheck R., Giannis A. (2003). Niedermolekulare Verbindungen als Inhibitoren cyclin-abhangiger Kinasen. Angew. Chem., 115, 2170-2175.
-
(2003)
Angew. Chem.
, vol.115
, pp. 2170-2175
-
-
Huwe, A.1
Mazitscheck, R.2
Giannis, A.3
-
41
-
-
27744489247
-
Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities
-
Moo M., Lee S. K., Lee J.-W., Song W.K., Kim S.W., Kim J.I., Cho C., Choi S.O., Kim Y.C. (2006). Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities. Bioorg. Med. Chem., 14, 237-246.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 237-246
-
-
Moo, M.1
Lee, S.K.2
Lee, J.-W.3
Song, W.K.4
Kim, S.W.5
Kim, J.I.6
Cho, C.7
Choi, S.O.8
Kim, Y.C.9
-
42
-
-
0029020282
-
Protein kinases 6, the eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks S.K., Hunter T. (1995). Protein kinases 6, the eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification. FASEB J., 9, 576-596.
-
(1995)
FASEB J.
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
43
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
Sato N., Meijer L., Skaltsounis L., Greengard P., Brivanlou A.H. (2004). Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med., 10, 55-63.
-
(2004)
Nat. Med.
, vol.10
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
44
-
-
2442589341
-
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase 3 and cyclin dependent kinases
-
Polychronopoulos P., Magiatis P., Skaltosounis A.L., Myrianthopoulos V., Mikros E., Tarricone A., Musacchino A., Mark Roe S., Pearl L., Greengard P., Meijer L. (2004). Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase 3 and cyclin dependent kinases. J. Med. Chem., 12, 935-946.
-
(2004)
J. Med. Chem.
, vol.12
, pp. 935-946
-
-
Polychronopoulos, P.1
Magiatis, P.2
Skaltosounis, A.L.3
Myrianthopoulos, V.4
Mikros, E.5
Tarricone, A.6
Musacchino, A.7
Mark Roe, S.8
Pearl, L.9
Greengard, P.10
Meijer, L.11
-
45
-
-
0346875916
-
GSK-3-selective inhibitors derived from tyrian purple indirubins
-
Meijer L., Skaltosounis A.L., Magiatis P., Polychronopoulos P-. Knockaert M.L., Ryan X., Vonica C.A., Brivanlou A., Dajani R., Crovace C., Tarricone C., Musacchino A., Mark Roe S., Pearl L., Greengard P. (2003). GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem. Biol., 10, 1255-1266.
-
(2003)
Chem. Biol.
, vol.10
, pp. 1255-1266
-
-
Meijer, L.1
Skaltosounis, A.L.2
Magiatis, P.3
Polychronopoulos, P.4
Knockaert, M.L.5
Ryan, X.6
Vonica, C.A.7
Brivanlou, A.8
Dajani, R.9
Crovace, C.10
Tarricone, C.11
Musacchino, A.12
Mark Roe, S.13
Pearl, L.14
Greengard, P.15
-
47
-
-
0022453514
-
Manzamine A, a novel antitumor alkaloid from a sponge
-
Sakai R., Higa T., Jefford C.W., Bernardinelli G. (1986). Manzamine A, a novel antitumor alkaloid from a sponge. J. Am. Chem. Soc., 108, 6404.
-
(1986)
J. Am. Chem. Soc.
, vol.108
, pp. 6404
-
-
Sakai, R.1
Higa, T.2
Jefford, C.W.3
Bernardinelli, G.4
-
48
-
-
2142818194
-
-
Cordell, G.A., ed, New York: Elsevier Science
-
Hu J.F., Hamann M.T., Hill R.S., Kelly M. (2003). In Cordell, G.A., ed., The Manzamine Alkaloids: The Alkaloids, New York: Elsevier Science, 207-285.
-
(2003)
The Manzamine Alkaloids: The Alkaloids
, pp. 207-285
-
-
Hu, J.F.1
Hamann, M.T.2
Hill, R.S.3
Kelly, M.4
-
49
-
-
10744228021
-
Manadomanzamines A and B, a novel alkaloid ring system with potent activity against mycobacteria and HIV-1
-
Peng J., Hu J.-F., Kazi A.B., Li Z., Avery M., Peraud O., Hill R., Franzblau S.G., Zhang F., Schinazi R.F., Wirtz S.S., Tharnish P., Kelly M., Wahyuono S., Hamann M.T. (2003). Manadomanzamines A and B, a novel alkaloid ring system with potent activity against mycobacteria and HIV-1. J. Am. Chem. Soc., 125, 13382.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 13382
-
-
Peng, J.1
Hu, J.-F.2
Kazi, A.B.3
Li, Z.4
Avery, M.5
Peraud, O.6
Hill, R.7
Franzblau, S.G.8
Zhang, F.9
Schinazi, R.F.10
Wirtz, S.S.11
Tharnish, P.12
Kelly, M.13
Wahyuono, S.14
Hamann, M.T.15
-
50
-
-
33747439379
-
Manzamine B and E and Ircinal A related alkaloids from an Indonesian Acanthostrong ylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's disease
-
in press
-
Rao K.V., Donia M.S., Peng J., García-Palomero E., Alonso D., Martínez A., Medina M., Franzblau S.G., Tekwani B.L., Khan S.I., Wahyuono S., Willett C., Hamann M.T. (2006). Manzamine B and E and Ircinal A related alkaloids from an Indonesian Acanthostrong ylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's disease. J. Nat. Prod., in presss.
-
(2006)
J. Nat. Prod
-
-
Rao, K.V.1
Donia, M.S.2
Peng, J.3
García-Palomero, E.4
Alonso, D.5
Martínez, A.6
Medina, M.7
Franzblau, S.G.8
Tekwani, B.L.9
Khan, S.I.10
Wahyuono, S.11
Willett, C.12
Hamann, M.T.13
-
51
-
-
0034329543
-
Phosphorylation of human Tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants
-
Flaherty D.B., Soria J.P., Tomasiewicz H.G., Wood J.G. (2000). Phosphorylation of human Tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants. J. Neurosci. Res., 62, 463-472.
-
(2000)
J. Neurosci. Res.
, vol.62
, pp. 463-472
-
-
Flaherty, D.B.1
Soria, J.P.2
Tomasiewicz, H.G.3
Wood, J.G.4
-
52
-
-
84947307115
-
-
Alonso D., Dorronsoro I., Martines A., Panizo G., Fuertes A., Perez J., Martín E., Perez D., Medina M. (Neuropharma S.A). (2005). WO 05054221. GSK-3 Inhibitors isolated from marine organisms.
-
(2005)
WO 05054221. GSK-3 Inhibitors isolated from marine organisms
-
-
Alonso, D.1
Dorronsoro, I.2
Martines, A.3
Panizo, G.4
Fuertes, A.5
Perez, J.6
Martín, E.7
Perez, D.8
Medina, M.9
Neuropharma, S.A.10
-
53
-
-
0018719792
-
Palinurin, a new linear sesterterpene from a marine sponge
-
Alfano G., Cimino G., De Stefano S. (1979). Palinurin, a new linear sesterterpene from a marine sponge. Experentia, 35, 1135-1137.
-
(1979)
Experentia
, vol.35
, pp. 1135-1137
-
-
Alfano, G.1
Cimino, G.2
De Stefano, S.3
-
54
-
-
0037331769
-
New cytotoxic furanosesquiterpenes from an Okinawan marine sponge
-
Issa HH., Tanaka J., Higa T. (2003). New cytotoxic furanosesquiterpenes from an Okinawan marine sponge, Ircinia sp. J. Nat. Prod., 66, 251-254.
-
(2003)
Ircinia sp. J. Nat. Prod.
, vol.66
, pp. 251-254
-
-
Issa, H.H.1
Tanaka, J.2
Higa, T.3
-
55
-
-
0035094212
-
Cheilanthane sesterpenes, protein kinases inhibitors, from a marine sponge of the genus
-
Buchanan MS., Edser A. (2001). Cheilanthane sesterpenes, protein kinases inhibitors, from a marine sponge of the genus Ircinia. J. Nat. Prod., 64, 300-303.
-
(2001)
Ircinia. J. Nat. Prod.
, vol.64
, pp. 300-303
-
-
Buchanan, M.S.1
Edser, A.2
-
56
-
-
49549165124
-
Variabilin, an antibiotic from the sponge
-
Faulkner J. (1973). Variabilin, an antibiotic from the sponge, Ircinia variabilis Tetrahedron Lett., 14, 3821-3822.
-
(1973)
Ircinia variabilis Tetrahedron Lett.
, vol.14
, pp. 3821-3822
-
-
Faulkner, J.1
-
57
-
-
0032776729
-
The biocatalytic transformation of furan to amide in the bioactive marine natural product palinurin
-
El Sayed K., Mayer A.M., Kelly M., Hamann M.T. (1999). The biocatalytic transformation of furan to amide in the bioactive marine natural product palinurin. J. Org. Chem., 64, 9258-9260.
-
(1999)
J. Org. Chem.
, vol.64
, pp. 9258-9260
-
-
El Sayed, K.1
Mayer, A.M.2
Kelly, M.3
Hamann, M.T.4
-
58
-
-
17444423677
-
Estrogens and brain: Synthesis, function and diseases
-
Li R., Shen Y. (2005). Estrogens and brain: Synthesis, function and diseases. Front. Biosci., 10, 257-267.
-
(2005)
Front. Biosci.
, vol.10
, pp. 257-267
-
-
Li, R.1
Shen, Y.2
-
59
-
-
0035925762
-
Hormone replacement therapy and cognition: Systematic review and metanalysis
-
LeBlanc E.S., Janowsky J., Chan B.K., Nelson H.D. (2001). Hormone replacement therapy and cognition: Systematic review and metanalysis. JAMA, 285, 1489-1499.
-
(2001)
JAMA
, vol.285
, pp. 1489-1499
-
-
LeBlanc, E.S.1
Janowsky, J.2
Chan, B.K.3
Nelson, H.D.4
-
60
-
-
0023664272
-
Genistein, a specific inhibitor of tyrosine-specific protein kinase
-
Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M., Fukami Y. (1987). Genistein, a specific inhibitor of tyrosine-specific protein kinase. J. Biol. Chem., 262, 5592-5595.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 5592-5595
-
-
Akiyama, T.1
Ishida, J.2
Nakagawa, S.3
Ogawara, H.4
Watanabe, S.5
Itoh, N.6
Shibuya, M.7
Fukami, Y.8
-
61
-
-
0034956425
-
Actions of the soy phytoestrogen genistein in models of human chronis disease:Potential involvement of transforming growth factor β
-
Kim H., Xu J., Xia H., Li L., Peterson G., Murphy-Ullrich J., Barnes S. (2001). Actions of the soy phytoestrogen genistein in models of human chronis disease:Potential involvement of transforming growth factor β Biochem. Soc. Trans., 29, 216-222.
-
(2001)
Biochem. Soc. Trans.
, vol.29
, pp. 216-222
-
-
Kim, H.1
Xu, J.2
Xia, H.3
Li, L.4
Peterson, G.5
Murphy-Ullrich, J.6
Barnes, S.7
-
62
-
-
26444582959
-
Soy isofl avone glycitein protects against beta amyloidinduced toxicity and oxidative stress in transgenic Caenorhabditis elegans
-
Gutierrez-Zepeda A., Santell R., Wu Z., Brown M., Wu Y., Khan I., Link C.D., Zhao B., Luo Y. (2005). Soy isofl avone glycitein protects against beta amyloidinduced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neurosci., 6, 54-63.
-
(2005)
BMC Neurosci.
, vol.6
, pp. 54-63
-
-
Gutierrez-Zepeda, A.1
Santell, R.2
Wu, Z.3
Brown, M.4
Wu, Y.5
Khan, I.6
Link, C.D.7
Zhao, B.8
Luo, Y.9
-
63
-
-
84947307659
-
-
http://www.clinicaltrials.gov/ct/show/NCT00205179
-
-
-
-
64
-
-
84947345571
-
-
10th International Conference on Alzheimer Diseases and Related Disorders, Madrid
-
Alonso D., Dorronsoro I., Panizo G., Martin-Aparicio E., Fuertes A., Pérez-Puerto M.J., Medina M., Fernandez-Chimeno R.I., Pérez-Baz J., Martínez A. (2006). glycogen synthase kinase-3β inhibitors from marine origin. 10th International Conference on Alzheimer Diseases and Related Disorders, Madrid.
-
(2006)
glycogen synthase kinase-3β inhibitors from marine origin
-
-
Alonso, D.1
Dorronsoro, I.2
Panizo, G.3
Martin-Aparicio, E.4
Fuertes, A.5
Pérez-Puerto, M.J.6
Medina, M.7
Fernandez-Chimeno, R.I.8
Pérez-Baz, J.9
Martínez, A.10
|