Inhibition of NFκB-mediated interleukin-1β-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 2, 1997, Pages 955-961

  Roshak, Amy ^a   Jackson, Jeffery R ^a   Chabot Fletcher, Marie ^a   Marshall, Lisa A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; NATURAL PRODUCT; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROTEIN KINASE C INHIBITOR; VASCULOTROPIN; AZEPINE DERIVATIVE; ENDOTHELIAL CELL GROWTH FACTOR; HYMENIALDISINE; INTERLEUKIN 1; LYMPHOKINE; PHOSPHOLIPASE A; PROSTAGLANDIN SYNTHASE; PYRROLE DERIVATIVE; VASCULOTROPIN A;

ADULT; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; SYNOVIOCYTE; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; METABOLISM; RHEUMATOID ARTHRITIS; SYNOVIUM;

ADULT; ARTHRITIS, RHEUMATOID; AZEPINES; CELLS, CULTURED; DINOPROSTONE; ENDOTHELIAL GROWTH FACTORS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-8; LYMPHOKINES; NF-KAPPA B; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES; SYNOVIAL MEMBRANE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0030612279     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. ADCOCK, I. M., SHIRASAKI, H., GELDER, C. M., PETERS, M. J., BROWN, C. R. AND BARNES, P. J.: The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. Life Sci. 55:1147-1153, 1994.
2. 2 and cyclooxygenase-2. Eur. J. Biochem. 226: 125-131, 1994.
3. AUPHAN, N., DIDONATO, J. A., ROSETTE, C., HELMBERG, A. AND KARIN, M.: Immunosuppression by glucocorticoids: inhibition of NFκB activity through induction of IκB synthesis. Science 270: 286-290, 1995.
4. BALDWIN, A.: The NFκB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 14: 649-681, 1996.
5. BIT, R. A., DAVIS, P. D., ELLIOTT, L. H., HARRIS, W., HILL, C. H., KEECH, E., KUMAR, H., LAWTON, G., MAW, A., NIXON, J. S., VESSY, D. R., WADSWORTH, J. AND WILKINSON, S. E.: Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restrction. J. Med. Chem. 36: 21-29, 1993.
6. BLACKWELL, T. S., HOLDEN, E. P., BLACKWELL, T. R., DELARCO, J. E. AND CHRISTMAN, J. W.: Cytokine-induced neutrophil chemoattractant mediates neutrophillic alveolitis in rats: association with nuclear factor κB activation. Am. J. Respir. Cell Mol. Biol. 11: 464-472, 1994.
7. BRETON, J. J. AND CHABOT-FLETCHER, M.: The natural product hymenialdisine inhibits IL-8 production in U937 cells by inhibition of NF-κB. J. Pharmacol. Exp. Ther. 282: 459-466, 1997.
8. CIMINO, G., DE ROSA, S., DE STEFANO, S., MAZZARELLA, L., PULITI, R. AND SODANO, G.: Isolation and x-ray crystal structure of a novel bromo-compound from two marine sponges. Tetrahedron Lett. 23: 767-768, 1982.
9. 2 production by human synovial cells. Clin. Invest. 77: 645-648, 1986.
10. DIGNAM, J. D., LEBOVITZ, R. M. AND ROEDER, R. G.: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475-1489, 1983.
11. DIMARTINO, M., WOLFF, C., PATIL, A. AND NAMBI, P.: Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats. Inflamm. Res. 44: suppl. 2, s123-s124, 1995.
12. FUJISAWA, K., AONO, H., HASUNUMA, T., YAMAMOTO, K., MITA, S. AND NISHIOKA, K.: Activation of transcription factor NF-κB in human synovial cells in response to tumor necrosis factor α. Arthritis Rheum. 39: 197-203, 1996.
13. 2 in human synovial cells. Arthritis Rheum. 31: 126-130, 1988.
14. 2 by rheumatoid arthritis synovial cells in culture. Cytokine 4: 377-384, 1992.
15. HANDEL, M. L., MCMORROW, L. B. AND GRAVALLESE, E. M.: Nuclear factor κB in rheumatoid synovium; localization of p50 and p65. Arthritis Rheum. 38: 1762-1770, 1995.
16. 2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Arthritis Rheum. 37: 653-661, 1994.
17. JACKSON, J. R., MINTON, J. A. L., HO, M. L. WEI, N. AND WINKLER, J. D.: Expression of VEGF in synovial fibroblasts is induced by hypoxia and interleukin 1β. J. Rheum. 24: 1253-1259, 1997.
18. KAWAI, M., NISHIKOMORI, R., JUNG, E.-Y., TAI, G., YAMANAK, C., MAYUMI, M. AND HEIKE, T.: Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. J. Immunol. 154: 2333-2341, 1995.
19. KOPP, E. AND GHOSH, S.: Inhibition of NF-κB by sodium salicylates and aspirin. Science 265: 956-959, 1994.
20. KUNSCH, C. AND ROSEN, C. A.: NF-κB subunit-specific regulation of the interleukin-8 promoter. Mol. Cell Biol. 13: 6137-6146, 1993.
21. LEDEBUR, H. C. AND PARKS, T. P.: Transcriptional regulation of the intracellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. J. Biol. Chem. 27: 933-943, 1995.
22. LI, C. C. H., DAI, R. M. AND LONGO, D. L.: Inactivation of NF-κB inhibitor IκBα: ubiquitin-dependent proteolysis and its degradation product. Biochem. Biophys. Res. Commun. 215: 292-301, 1995.
23. LIAO, F., ANDALIBI, A., QIAO, J. H., ALLAYEE, H., FOGELMAN, A. AND Lusis, A.: Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J. Clin. Invest. 94: 877-884, 1994.
24. LIBERMANN, T. A. AND BALTIMORE, D.: Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell Biol. 10: 2327-2334, 1990.
25. MATSUSAKA, T., FUJIKAWA, K., NISHIO, Y., MUKAIDA, N., MATSUSHIMA, K., KISHIMOTO, T. AND AKIRA, S.: Transcription factors NF-IL6 and NFκB synergistically activate transcription of the inflammatory cytokines interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. U.S.A. 90: 10193-10197, 1993.
26. MIYAMOTO, S. AND VERMA. I. M.: Rel/NF-κB/κB story. Adv. Cancer Res. 66: 255-292, 1995.
27. MUKAIDA, N., SHIROO, M. AND MATSUSHIMA, K.: Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. J. Immunol. 143: 1366-1371, 1989.
28. MUKHOPADHYAY, D., TSIOKAS, L., ZHOU, X.-M., FOSTER, D., BRUGGE, J. S. AND SUKHATME, V. P.: Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature 375: 577-581, 1995.
29. MULLER, S., KAMMERBAUER, C., SIMONS, U., SHIBAGAKI N., LI, L. J., CAUGHMAN, S. W. AND DEGITZ, K.: Transcriptional regulation of intracellular adhesion molecule-1:PMA-induction is mediated by NFκB. J. Invest. Dermatol. 104: 970-975, 1995.
30. OSBORN, L., KUNKEL, L. S. AND NABEL, G. J.: Tumor necrosis factor α and interleukin-1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB. Proc. Natl. Acad. Sci. U.S.A. 86: 2336-23340, 1989.
31. PALOMBELLA, V. J., RANDO, O. J., GOLDBERG, A. L. AND MANIATIS, T.: The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78: 773-785, 1994.
32. 2. J. Rheum. 23: 420-427, 1996a.
33. ROSHAK, A., JACKSON, J. R., MCGOUGH, K., CHABOT-FLETCHER, M., MOCHAN, E. AND MARSHALL, L. A.: Manipulation of distinct NFκB proteins alters interleukin-1β induced human rheumatoid synovial fibroblast prostaglandin E2 formation. J. Biol. Chem. 271: 31496-31501, 1996b.
34. SCHEINMAN, R. I., COGSWELL, P. C., LOFQUIST, A. K. AND BALDWIN, JR., A. S.: Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270: 283-286, 1995.
35. SIEBENLIST, U., FRANZOSO, G. AND BROWN, K.: Structure, regulation and function of NFκB. Annu. Rev. Cell Biol. 10: 405-455, 1994.
36. SHU, H. B., AGRANOFF, A. B., NABEL, E. G., LEUNG, K., DUCKETT, C. S., NEISH, A. S., COLLINS, T. AND NABEL, G. J.: Differential regulation of vascular cell adhesion molecule-1 gene expression by specific NFκB subunits in endothelial and epithelial cells. Mol. Cell Biol. 13: 6283-6289, 1993.
37. SIPE, J. D., MARTEL-PELLETIER, J., OTTERNESS, I. G. AND PELLETIER, J. P.: Cytokine reduction in the treatment of joint conditions. Med. Inflam. 3: 243-256, 1994.
38. THANOS, D. AND MANIATIS, T.: NFκB: A lesson in family values. Cell 80: 529-532, 1995.
39. TISCHER, E., MITCHELL, R., HARTMAN, T., SILVA, M., GOSPODAROWICZ, D., FIDDES, J. C. AND ABRAHAM, J. A.: The human gene for vascular endothelial growth factor. J. Biol. Chem. 266: 11947-11954, 1991.
40. TRAENCKNER, E. B.-M., WILK, S. AND BAEUERLE, P. A.: A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13: 5433-5441, 1994.