Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy

American Journal of Physiology - Endocrinology and Metabolism

Volumn 309, Issue 10, 2015, Pages 861-873

  Wang, Fang ^a   Weng, Hongbo ^a   Quon, Michael J ^b   Yu, Jingwen ^a   Wang, Jian Ying ^c   Hueber, Anne Odile ^d   Yang, Peixin ^a,e  

^a Gynecology and Reproductive Sciences   (United States)

^b Department of Medicine ^*  (United States)

^c Department of Surgery   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e CENTRE DE BIOCHIMIE   (France)

Author keywords

Apoptosis; Dominant negative Fas associated protein with death domain; Endoplasmic reticulum stress; Maternal diabetes; Neural tube defects; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; APOPTOSIS SIGNAL REGULATING KINASE 1; BIM PROTEIN; CASPASE 3; CASPASE 8; FAS ASSOCIATED DEATH DOMAIN PROTEIN; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING ENZYME 1 ALPHA; JANUS KINASE 1; JANUS KINASE 2; MICRORNA; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PUMA PROTEIN; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUNICAMYCIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; FADD PROTEIN, HUMAN; HYBRID PROTEIN; IRE1ALPHA PROTEIN, RAT; MULTIENZYME COMPLEX; MUTANT PROTEIN; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; TRADD PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC EMBRYOPATHY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; EMBRYONIC STEM CELL; EMBRYOPATHY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MATERNAL DIABETES MELLITUS; MITOCHONDRION; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA SPLICING; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; C57BL MOUSE; CELL LINE; DOWN REGULATION; EMBRYOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HUMAN; MAMMALIAN EMBRYO; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE DEFECTS; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; PREGNANCY DIABETES MELLITUS; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BIOMARKERS; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DOWN-REGULATION; EMBRYO, MAMMALIAN; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FEMALE; HUMANS; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIENZYME COMPLEXES; MUTANT PROTEINS; NEURAL TUBE DEFECTS; NEUROGENESIS; PREGNANCY; PREGNANCY IN DIABETICS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; UNFOLDED PROTEIN RESPONSE;

EID: 84947286958     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00215.2015     Document Type: Article

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