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Volumn 305, Issue 5, 2013, Pages

Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis

Author keywords

Autophagy; Diabetic embryopathy; Neural tube defects; Neurogenesis; Trehalose

Indexed keywords

TRANSCRIPTION FACTOR SOX1; TREHALOSE;

EID: 84883792196     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00185.2013     Document Type: Article
Times cited : (75)

References (56)
  • 1
    • 79955850909 scopus 로고    scopus 로고
    • A differential autophagic response to hyperglycemia in the developing murine embryo
    • Adastra KL, Chi MM, Riley JK, Moley KH. A differential autophagic response to hyperglycemia in the developing murine embryo. Reproduction 141: 607-615, 2011.
    • (2011) Reproduction , vol.141 , pp. 607-615
    • Adastra, K.L.1    Chi, M.M.2    Riley, J.K.3    Moley, K.H.4
  • 3
    • 0025017481 scopus 로고
    • Diabetes mellitus during pregnancy and the risks for specific birth defects: A populationbased case-control study
    • Becerra JE, Khoury MJ, Cordero JF, Erickson JD. Diabetes mellitus during pregnancy and the risks for specific birth defects: a populationbased case-control study. Pediatrics 85: 1-9, 1990.
    • (1990) Pediatrics , vol.85 , pp. 1-9
    • Becerra, J.E.1    Khoury, M.J.2    Cordero, J.F.3    Erickson, J.D.4
  • 4
    • 33845480131 scopus 로고    scopus 로고
    • Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
    • Bernales S, McDonald KL, Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 4: e423, 2006.
    • (2006) PLoS Biol , vol.4
    • Bernales, S.1    McDonald, K.L.2    Walter, P.3
  • 5
    • 4644236078 scopus 로고    scopus 로고
    • Role of trehalose phosphate synthase and trehalose during hypoxia: From flies to mammals
    • Chen Q, Haddad GG. Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals. J Exp Biol 207: 3125-3129, 2004.
    • (2004) J Exp Biol , vol.207 , pp. 3125-3129
    • Chen, Q.1    Haddad, G.G.2
  • 6
    • 67549084381 scopus 로고    scopus 로고
    • Superoxide is the major reactive oxygen species regulating autophagy
    • Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ 16: 1040-1052, 2009.
    • (2009) Cell Death Differ , vol.16 , pp. 1040-1052
    • Chen, Y.1    Azad, M.B.2    Gibson, S.B.3
  • 8
    • 0141483382 scopus 로고    scopus 로고
    • The genetic basis of mammalian neurulation
    • Copp AJ, Greene ND, Murdoch JN. The genetic basis of mammalian neurulation. Nat Rev 4: 784-793, 2003.
    • (2003) Nat Rev , vol.4 , pp. 784-793
    • Copp, A.J.1    Greene, N.D.2    Murdoch, J.N.3
  • 10
    • 29644437591 scopus 로고    scopus 로고
    • Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy
    • Davies JE, Sarkar S, Rubinsztein DC. Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet 15: 23-31, 2006.
    • (2006) Hum Mol Genet , vol.15 , pp. 23-31
    • Davies, J.E.1    Sarkar, S.2    Rubinsztein, D.C.3
  • 13
    • 43949143804 scopus 로고    scopus 로고
    • The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
    • Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell 19: 2092-2100, 2008.
    • (2008) Mol Biol Cell , vol.19 , pp. 2092-2100
    • Fujita, N.1    Itoh, T.2    Omori, H.3    Fukuda, M.4    Noda, T.5    Yoshimori, T.6
  • 14
    • 33845912680 scopus 로고    scopus 로고
    • Maternal diabetes in vivo and high glucose concentration in vitro increases apoptosis in rat embryos
    • Gäreskog M, Cederberg J, Eriksson UJ, Wentzel P. Maternal diabetes in vivo and high glucose concentration in vitro increases apoptosis in rat embryos. Reprod Toxicol 23: 63-74, 2007.
    • (2007) Reprod Toxicol , vol.23 , pp. 63-74
    • Gäreskog, M.1    Cederberg, J.2    Eriksson, U.J.3    Wentzel, P.4
  • 15
    • 0024564676 scopus 로고
    • First-trimester hemoglobin A1 and risk for major malformation and spontaneous abortion in diabetic pregnancy
    • Greene MF, Hare JW, Cloherty JP, Benacerraf BR, Soeldner JS. First-trimester hemoglobin A1 and risk for major malformation and spontaneous abortion in diabetic pregnancy. Teratology 39: 225-231, 1989.
    • (1989) Teratology , vol.39 , pp. 225-231
    • Greene, M.F.1    Hare, J.W.2    Cloherty, J.P.3    Benacerraf, B.R.4    Soeldner, J.S.5
  • 16
    • 0031033593 scopus 로고    scopus 로고
    • Inositol prevents folate-resistant neural tube defects in the mouse
    • Greene ND, Copp AJ. Inositol prevents folate-resistant neural tube defects in the mouse. Nat Med 3: 60-66, 1997.
    • (1997) Nat Med , vol.3 , pp. 60-66
    • Greene, N.D.1    Copp, A.J.2
  • 18
    • 0029595271 scopus 로고
    • Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
    • Ishibashi M, Ang SL, Shiota K, Nakanishi S, Kageyama R, Guillemot F. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev 9: 3136-3148, 1995.
    • (1995) Genes Dev , vol.9 , pp. 3136-3148
    • Ishibashi, M.1    Ang, S.L.2    Shiota, K.3    Nakanishi, S.4    Kageyama, R.5    Guillemot, F.6
  • 20
    • 71549124671 scopus 로고    scopus 로고
    • Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells
    • Kiyono K, Suzuki HI, Matsuyama H, Morishita Y, Komuro A, Kano MR, Sugimoto K, Miyazono K. Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells. Cancer Res 69: 8844-8852, 2009.
    • (2009) Cancer Res , vol.69 , pp. 8844-8852
    • Kiyono, K.1    Suzuki, H.I.2    Matsuyama, H.3    Morishita, Y.4    Komuro, A.5    Kano, M.R.6    Sugimoto, K.7    Miyazono, K.8
  • 21
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • Levine B, Yuan J. Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 22
    • 25144443988 scopus 로고    scopus 로고
    • Hypoxic stress in diabetic pregnancy contributes to impaired embryo gene expression and defective development by inducing oxidative stress
    • Li R, Chase M, Jung SK, Smith PJ, Loeken MR. Hypoxic stress in diabetic pregnancy contributes to impaired embryo gene expression and defective development by inducing oxidative stress. Am J Physiol Endocrinol Metab 289: E591-E599, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Li, R.1    Chase, M.2    Jung, S.K.3    Smith, P.J.4    Loeken, M.R.5
  • 23
    • 84864392621 scopus 로고    scopus 로고
    • Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy
    • Li X, Weng H, Xu C, Reece EA, Yang P. Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy. Diabetes 61: 2084-2092, 2012.
    • (2012) Diabetes , vol.61 , pp. 2084-2092
    • Li, X.1    Weng, H.2    Xu, C.3    Reece, E.A.4    Yang, P.5
  • 24
    • 84873043548 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy
    • Li X, Xu C, Yang P. c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes 62: 599-608, 2013.
    • (2013) Diabetes , vol.62 , pp. 599-608
    • Li, X.1    Xu, C.2    Yang, P.3
  • 25
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490, 1998.
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 26
    • 44449129923 scopus 로고    scopus 로고
    • Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo
    • Lupu F, Alves A, Anderson K, Doye V, Lacy E. Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Dev Cell 14: 831-842, 2008.
    • (2008) Dev Cell , vol.14 , pp. 831-842
    • Lupu, F.1    Alves, A.2    Anderson, K.3    Doye, V.4    Lacy, E.5
  • 28
    • 0035033448 scopus 로고    scopus 로고
    • Diabetic embryopathy in C57BL/6J mice. Altered fetal sex ratio and impact of the splotch allele
    • Machado AF, Zimmerman EF, Hovland DN Jr, Weiss R, Collins MD. Diabetic embryopathy in C57BL/6J mice. Altered fetal sex ratio and impact of the splotch allele. Diabetes 50: 1193-1199, 2001.
    • (2001) Diabetes , vol.50 , pp. 1193-1199
    • McHado, A.F.1    Zimmerman, E.F.2    Hovland Jr., D.N.3    Weiss, R.4    Collins, M.D.5
  • 29
  • 30
    • 77956416339 scopus 로고    scopus 로고
    • Autophagy in mammalian development and differentiation
    • Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 12: 823-830, 2010.
    • (2010) Nat Cell Biol , vol.12 , pp. 823-830
    • Mizushima, N.1    Levine, B.2
  • 31
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111, 2004.
    • (2004) Mol Biol Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 33
    • 0036723777 scopus 로고    scopus 로고
    • Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy
    • Pani L, Horal M, Loeken MR. Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy. Diabetes 51: 2871-2874, 2002.
    • (2002) Diabetes , vol.51 , pp. 2871-2874
    • Pani, L.1    Horal, M.2    Loeken, M.R.3
  • 34
    • 67949097345 scopus 로고    scopus 로고
    • Maternal diabetes alters transcriptional programs in the developing embryo
    • Pavlinkova G, Salbaum JM, Kappen C. Maternal diabetes alters transcriptional programs in the developing embryo. BMC Genomics 10: 274, 2009.
    • (2009) BMC Genomics , vol.10 , pp. 274
    • Pavlinkova, G.1    Salbaum, J.M.2    Kappen, C.3
  • 37
    • 77955595308 scopus 로고    scopus 로고
    • Neural tube defect genes and maternal diabetes during pregnancy
    • Salbaum JM, Kappen C. Neural tube defect genes and maternal diabetes during pregnancy. Birth Defects Res 88: 601-611, 2010.
    • (2010) Birth Defects Res , vol.88 , pp. 601-611
    • Salbaum, J.M.1    Kappen, C.2
  • 38
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 282: 5641-5652, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 39
    • 79954519615 scopus 로고    scopus 로고
    • Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes
    • Schaible TD, Harris RA, Dowd SE, Smith CW, Kellermayer R. Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. Hum Mol Genet 20: 1687-1696, 2011.
    • (2011) Hum Mol Genet , vol.20 , pp. 1687-1696
    • Schaible, T.D.1    Harris, R.A.2    Dowd, S.E.3    Smith, C.W.4    Kellermayer, R.5
  • 40
    • 4143132015 scopus 로고    scopus 로고
    • Hyperglycemia-induced TGFbeta and fibronectin expression in embryonic mouse heart
    • Smoak IW. Hyperglycemia-induced TGFbeta and fibronectin expression in embryonic mouse heart. Dev Dyn 231: 179-189, 2004.
    • (2004) Dev Dyn , vol.231 , pp. 179-189
    • Smoak, I.W.1
  • 41
    • 64549155245 scopus 로고    scopus 로고
    • Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes
    • Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia 52: 962-971, 2009.
    • (2009) Diabetologia , vol.52 , pp. 962-971
    • Sugimura, Y.1    Murase, T.2    Oyama, K.3    Uchida, A.4    Sato, N.5    Hayasaka, S.6    Kano, Y.7    Takagishi, Y.8    Hayashi, Y.9    Oiso, Y.10    Murata, Y.11
  • 45
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666, 2000.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 46
    • 69449086137 scopus 로고    scopus 로고
    • Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy
    • Wang A, Hascall VC. Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy. Autophagy 5: 864-865, 2009.
    • (2009) Autophagy , vol.5 , pp. 864-865
    • Wang, A.1    Hascall, V.C.2
  • 47
    • 0025863475 scopus 로고
    • Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
    • No authors listed, MRC Vitamin Study Research Group
    • No authors listed. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 338: 131-137, 1991.
    • (1991) Lancet , vol.338 , pp. 131-137
  • 48
    • 84862812867 scopus 로고    scopus 로고
    • SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy
    • Weng H, Li X, Reece EA, Yang P. SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy. Am J Obstet Gynecol 206: 448 e441-e447, 2012.
    • (2012) Am J Obstet Gynecol , vol.206
    • Weng, H.1    Li, X.2    Reece, E.A.3    Yang, P.4
  • 49
    • 0037406474 scopus 로고    scopus 로고
    • Maternal diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos
    • Wentzel P, Ejdesjo A, Eriksson UJ. Maternal diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos. Diabetes 52: 1222-1228, 2003.
    • (2003) Diabetes , vol.52 , pp. 1222-1228
    • Wentzel, P.1    Ejdesjo, A.2    Eriksson, U.J.3
  • 50
    • 12744254882 scopus 로고    scopus 로고
    • Folic acid supplementation diminishes diabetes-and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro
    • Wentzel P, Gareskog M, Eriksson UJ. Folic acid supplementation diminishes diabetes-and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro. Diabetes 54: 546-553, 2005.
    • (2005) Diabetes , vol.54 , pp. 546-553
    • Wentzel, P.1    Gareskog, M.2    Eriksson, U.J.3
  • 52
    • 79951720176 scopus 로고    scopus 로고
    • JNK regulates FoxO-dependent autophagy in neurons
    • Xu P, Das M, Reilly J, Davis RJ. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 25: 310-322, 2011.
    • (2011) Genes Dev , vol.25 , pp. 310-322
    • Xu, P.1    Das, M.2    Reilly, J.3    Davis, R.J.4
  • 53
    • 79953286300 scopus 로고    scopus 로고
    • Role of HIF-1alpha in maternal hyperglycemiainduced embryonic vasculopathy
    • Yang P, Reece EA. Role of HIF-1alpha in maternal hyperglycemiainduced embryonic vasculopathy. Am J Obstet Gynecol 204: 332. e1-332. e7, 2011.
    • (2011) Am J Obstet Gynecol , vol.204
    • Yang, P.1    Reece, E.A.2
  • 54
    • 37349093674 scopus 로고    scopus 로고
    • Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy
    • Yang P, Zhao Z, Reece EA. Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy. Am J Obstet Gynecol 198: 130. e1-130. e7, 2008.
    • (2008) Am J Obstet Gynecol , vol.198
    • Yang, P.1    Zhao, Z.2    Reece, E.A.3
  • 55
    • 34247528120 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy
    • Yang P, Zhao Z, Reece EA. Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy. Biochem Biophys Res Commun 357: 749-754, 2007.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 749-754
    • Yang, P.1    Zhao, Z.2    Reece, E.A.3
  • 56
    • 0028899554 scopus 로고
    • Altered mitochondrial morphology of rat embryos in diabetic pregnancy
    • Yang X, Borg LA, Eriksson UJ. Altered mitochondrial morphology of rat embryos in diabetic pregnancy. Anat Rec 241: 255-267, 1995.
    • (1995) Anat Rec , vol.241 , pp. 255-267
    • Yang, X.1    Borg, L.A.2    Eriksson, U.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.