Nε-(Carboxymethyl) lysine-induced mitochondrial fission and mitophagy cause decreased insulin secretion from β-cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 309, Issue 10, 2015, Pages 829-839

  Lo, Mei Chen ^a,b   Chen, Ming Hong ^c   Lee, Wen Sen ^a   Lu, Chin I ^b   Chang, Chuang Rung ^d   Kao, Shu Huei ^b   Lee, Horng Mo ^a,b,e  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c SAINT PAUL S HOSPITAL   (Taiwan)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^e CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Advanced glycated end products; Diabetes; Mitochondrial dynamics; Mitophagy

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADENOSINE TRIPHOSPHATE; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; BOVINE SERUM ALBUMIN; DYNAMIN I; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LIPID PEROXIDE; MITOCHONDRIAL DNA; MITOFUSIN 1; MITOFUSIN 2; PARKIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE INDUCED PUTATIVE KINASE 1; PROINSULIN; PROTEIN; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; TOPM 20 PROTEIN; UNCLASSIFIED DRUG; ADVANCED GLYCATION END PRODUCTS-BOVINE SERUM ALBUMIN; AGER PROTEIN, MOUSE; ANTIOXIDANT; BIOLOGICAL MARKER; LYSINE; N(6)-CARBOXYMETHYLLYSINE; OXIDIZING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL AGGREGATION; CELL FUSION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEPOLARIZATION; DIABETES MELLITUS; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; INSULINOMA CELL LINE; LIPID PEROXIDATION; MALE; MEMBRANE BIOLOGY; MICROBIAL MORPHOLOGY; MITOCHONDRIAL AGGREGATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL FISSION; MITOCHONDRIAL FUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOCHONDRION SWELLING; MITOPHAGY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; WILD TYPE; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DIET SUPPLEMENTATION; DIET THERAPY; DOWN REGULATION; DRUG EFFECTS; METABOLISM; MUTANT MOUSE STRAIN; PATHOLOGY; PHAGOSOME; RAT; SECRETION (PROCESS); TUMOR CELL LINE; ULTRASTRUCTURE;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; ANTIOXIDANTS; BIOMARKERS; CELL LINE, TUMOR; DIABETES MELLITUS; DIETARY SUPPLEMENTS; DOWN-REGULATION; GLYCOSYLATION END PRODUCTS, ADVANCED; INSULIN; INSULIN-SECRETING CELLS; LYSINE; MALE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL DYNAMICS; OXIDANTS; PHAGOSOMES; RATS; SERUM ALBUMIN, BOVINE; THIOCTIC ACID;

EID: 84947230056     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00151.2015     Document Type: Article

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