Mitochondrial DNA aberrations and pathophysiological implications in hematopoietic diseases, chronic inflammatory diseases, and cancers

Annals of Laboratory Medicine

Volumn 35, Issue 1, 2015, Pages 1-14

  Kim, Hye Ran ^a,b   Won, Stephanie Jane ^c   Fabian, Claire ^d   Kang, Min Gu ^a,b   Szardenings, Michael ^d   Shin, Myung Geun ^a,b  

^a Chonnam National University Hwasun Hospital and Medical School   (South Korea)

^b Chonnam National University   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

Author keywords

Aberrations; Diseases; MtDNA

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

GENETICS; HEMATOLOGIC DISEASE; HUMAN; INFLAMMATION; METABOLISM; MITOCHONDRION; MUTATION; NEOPLASM; OXIDATIVE STRESS; PATHOLOGY;

DNA, MITOCHONDRIAL; HEMATOLOGIC DISEASES; HUMANS; INFLAMMATION; MITOCHONDRIA; MUTATION; NEOPLASMS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84920507780     PISSN: 22343806     EISSN: 22343814     Source Type: Journal    
DOI: 10.3343/alm.2015.35.1.1     Document Type: Review

References (37)

1. Reeve AK, Krishnan KJ, Turnbull D. Mitochondrial DNA mutations in disease, aging, and neurodegeneration. Ann N Y Acad Sci 2008;1147: 21-9.
2. Shin MG, Kajigaya S, Levin BC, Young NS. Mitochondrial DNA mutations in patients with myelodysplastic syndromes. Blood 2003;101: 3118-25.
3. Shin MG, Kajigaya S, Tarnowka M, McCoy JP Jr, Levin BC, Young NS. Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes. Blood 2004;103:4466-77.
4. Wallace DC. Mitochondrial DNA in aging and disease. Sci Am 1997; 277:40-7.
5. Hagberg H, Mallard C, Rousset CI, Thornton C. Mitochondria: hub of injury responses in the developing brain. Lancet Neurol 2014;13:217-32.
6. Raha S and Robinson BH. Mitochondria, oxygen free radicals, and apoptosis. Am J Med Genet 2001;106:62-70.
7. Berdanier CD and Everts HB. Mitochondrial DNA in aging and degenerative disease. Mutat Res 2001;475:169-83.
8. Shin MG, Levin BC, Kim HJ, Kim HR, Lee IK, Cho D, et al. Profiling of length heteroplasmies in the human mitochondrial DNA control regions from blood cells in the Korean population. Electrophoresis 2006;27: 1331-40.
9. Gattermann N. From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes. Leuk Res 2000;24:141-51.
10. Ergen AV and Goodell MA. Mechanisms of hematopoietic stem cell aging. Exp Gerontol 2010;45:286-90.
11. Park CB and Larsson NG. Mitochondrial DNA mutations in disease and aging. J Cell Biol 2011;193:809-18.
12. Shin MG, Kajigaya S, McCoy JP Jr, Levin BC, Young NS. Marked mito-chondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow. Blood 2004;103:553-61.
13. Liu Y, Long J, Liu J. Mitochondrial free radical theory of aging: Who moved my premise? Geriatr Gerontol Int 2014. doi: 10.1111/ggi.12296 [Epub ahead of print].
14. Stuart JA, Maddalena LA, Merilovich M, Robb EL. A midlife crisis for the mitochondrial free radical theory of aging. Longev Healthspan 2014; 3:4.
15. Barja G. Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid Redox Signal 2013;19:1420-45.
16. Kim HR, Shin MG, Kim MJ, Kim HJ, Shin JH, Suh SP, et al. Mitochon-drial DNA aberrations of bone marrow cells from patients with aplastic anemia. J Korean Med Sci 2008;23:1062-7.
17. He L, Luo L, Proctor SJ, Middleton PG, Blakely EL, Taylor RW, et al. Somatic mitochondrial DNA mutations in adult-onset leukaemia. Leukemia 2003;17:2487-91.
18. Yakes FM and Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A 1997;94:514-9.
19. Yao YG, Ogasawara Y, Kajigaya S, Molldrem JJ, Falcão RP, Pintão MC, et al. Mitochondrial DNA sequence variation in single cells from leukemia patients. Blood 2007;109:756-62.
20. Kwok CS, Quah TC, Ariffin H, Tay SK, Yeoh AE. Mitochondrial D-loop polymorphisms and mitochondrial DNA content in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2011;33:e239-44.
21. Carew JS, Zhou Y, Albitar M, Carew JD, Keating MJ, Huang P. Mito-chondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications. Leukemia 2003; 17:1437-47.
22. Cerezo M, Bandelt HJ, Martin-Guerrero I, Ardanaz M, Vega A, Carrace-do A, et al. High mitochondrial DNA stability in B-cell chronic lympho-cytic leukemia. PLoS One 2009;4:e7902.
23. Lan Q, Lim U, Liu CS, Weinstein SJ, Chanock S, Bonner MR, et al. A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma. Blood 2008;112:4247-9.
24. Ralph SJ and Neuzil J. Mitocans, a class of emerging anti-cancer drugs. Mol Nutr Food Res 2009;53:7-8.
25. Neuzil J, Dyason JC, Freeman R, Dong LF, Prochazka L, Wang XF, et al. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr 2007;39:65-72.
26. Shin MG, Kim HJ, Kim HR, Lee IK, Kook H, Cho D, et al. Mitochondrial DNA minisatellites as new markers for the quantitative determination of hematopoietic chimerism after allogeneic stem cell transplantation. Leukemia 2007;21:369-73.
27. Butler JM and Levin BC. Forensic applications of mitochondrial DNA. Trends Biotechnol 1998;16:158-62.
28. Lim SW, Kim HR, Kim HY, Huh JW, Kim YJ, Shin JH, et al. High-frequency minisatellite instability of the mitochondrial genome in colorectal cancer tissue associated with clinicopathological values. Int J Cancer 2012; 131:1332-41.
29. Yoo JH, Suh B, Park TS, Shin MG, Choi YD, Lee CH, et al. Analysis of fluorescence in situ hybridization, mtDNA quantification, and mtDNA sequence for the detection of early bladder cancer. Cancer Genet Cyto-genet 2010;198:107-17.
30. Lee S, Han MJ, Lee KS, Back SC, Hwang D, Kim HY, et al. Frequent occurrence of mitochondrial DNA mutations in Barrett's metaplasia without the presence of dysplasia. PLoS One 2012;7:e37571.
31. Park SY, Shin MG, Kim HR, Oh JY, Kim SH, Shin JH, et al. Alteration of mitochondrial DNA sequence and copy number in nasal polyp tissue. Mitochondrion 2009;9:318-25.
32. Lee S, Shin MG, Jo WH, Kim MJ, Kim HR, Lee WS, et al. Association between Helicobacter pylori-related peptic ulcer tissue and somatic mi-tochondrial DNA mutations. Clin Chem 2007;53:1390-2.
33. Park HW, Ahn Y, Jeong MH, Cho JG, Park JC, Kang JC, et al. Chronic atrial fibrillation associated with somatic mitochondrial DNA mutations in human atrial tissue. J Clin Pathol 2007;60:948-50.
34. Eom HY, Kim HR, Kim HY, Han DK, Baek HJ, Lee JH, et al. Mitochon-drial DNA copy number and hnRNP A2/B1 protein: biomarkers for direct exposure of benzene. Environ Toxicol Chem 2011;30:2762-70.
35. Raychoudhury SS and Kubinski D. Polycyclic aromatic hydrocarbon-induced cytotoxicity in cultured rat Sertoli cells involves differential apop-totic response. Environ Health Perspect 2003;111:33-8.
36. Phillips DH. Fifty years of benzo(a)pyrene. Nature 1983;303:468-72.
37. Castaño-Vinyals G, D'Errico A, Malats N, Kogevinas M. Biomarkers of exposure to polycyclic aromatic hydrocarbons from environmental air pollution. Occup Environ Med 2004;61:e12.