Sickle cell hemoglobin in the ferryl state promotes βCys-93 oxidation and mitochondrial dysfunction in Epithelial Lung Cells (E10)

Journal of Biological Chemistry

Volumn 290, Issue 46, 2015, Pages 27939-27958

  Kassa, Tigist ^a   Jana, Sirsendu ^a   Strader, Michael Brad ^a   Meng, Fantao ^a   Jia, Yiping ^a   Wilson, Michael T ^b   Alayash, Abdu I ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; BIOLOGICAL ORGANS; CATALYTIC OXIDATION; CELLS; CYTOLOGY; DROPS; IRON; MASS SPECTROMETRY; OXIDATION; PORPHYRINS;

LUNG EPITHELIAL CELLS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL OXYGEN CONSUMPTION; MITOCHONDRIAL TRANSMEMBRANE POTENTIALS; OXIDATION REACTIONS; QUANTITATIVE MASS SPECTROMETRIES; SICKLE CELL DISEASE; THERAPEUTIC MODALITY;

REACTION INTERMEDIATES;

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; HEME; HEME OXYGENASE 1; HEMOGLOBIN A; HEMOGLOBIN S; HYDROGEN PEROXIDE; IRON; METHEMOGLOBIN; 5,5-DIMETHYL-1-PYRROLINE-1-OXIDE; AMINE OXIDE; CYSTEINE; FERRYL IRON; HEME OXYGENASE;

ANIMAL CELL; ARTICLE; BIOENERGY; CELL ENERGY; CELLULAR DISTRIBUTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; LUNG ALVEOLUS EPITHELIUM CELL; MASS SPECTROMETRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; SICKLE CELL ANEMIA; SPIN TRAPPING; VASCULAR DISEASE; CATALYSIS; CHEMISTRY; ENERGY METABOLISM; ENZYMOLOGY; HEMOLYTIC ANEMIA; LUNG; METABOLISM; MITOCHONDRION; RESPIRATORY MUCOSA; ULTRASTRUCTURE;

ANEMIA, HEMOLYTIC; ANEMIA, SICKLE CELL; CATALYSIS; CYCLIC N-OXIDES; CYSTEINE; ENERGY METABOLISM; HEME; HEME OXYGENASE (DECYCLIZING); HEMOGLOBIN, SICKLE; HUMANS; HYDROGEN PEROXIDE; IRON; LUNG; METHEMOGLOBIN; MITOCHONDRIA; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; RESPIRATORY MUCOSA;

EID: 84947052011     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.651257     Document Type: Article

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