Structure of fully liganded Hb ζ2β2 strapped in a tense conformation

Acta Crystallographica Section D: Biological Crystallography

Volumn 69, Issue 10, 2013, Pages 2061-2071

  Safo, Martin K ^a   Ko, Tzu Ping ^b   Abdulmalik, Osheiza ^c   He, Zhenning ^d   Wang, Andrew H J ^b   Schreiter, Eric R ^e   Russell, J Eric ^c,d  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

2,3 disphosphoglycerate; allostery; Bohr effect; cooperativity; hemoglobin; relaxed state; tense state

Indexed keywords

HEMOGLOBIN; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN S; HEMOGLOBIN ZETA CHAIN; LIGAND; OXYGEN;

2,3-DISPHOSPHOGLYCERATE; ADULT; ALLOSTERISM; ANIMAL; ARTICLE; BLOOD; BOHR EFFECT; CHEMISTRY; COOPERATION; GENETIC VARIABILITY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RELAXED STATE; SICKLE CELL ANEMIA; TENSE STATE; TRANSGENIC MOUSE; X RAY CRYSTALLOGRAPHY;

2,3-DISPHOSPHOGLYCERATE; ALLOSTERY; BOHR EFFECT; COOPERATIVITY; HEMOGLOBIN; RELAXED STATE; TENSE STATE;

ADULT; ALLOSTERIC REGULATION; ALPHA-GLOBINS; ANEMIA, SICKLE CELL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; GENETIC VARIATION; HEMOGLOBIN, SICKLE; HUMANS; LIGANDS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; ZETA-GLOBINS;

EID: 84885442932     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444913019197     Document Type: Article

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